Machine-Assisted Organic Synthesis.
Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). email@example.com.Show MeSH
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Mentions: In 2012, our group made pioneering use of the Mettler–Toledo microscale ReactIR flow cell as an inline analytical tool to devise a new flow‐chemistry approach useful for the preparation of Grignard reagents that were not commercially available.83 We exemplified the strategy with a LiCl‐mediated halogen–Mg exchange reaction, performed using a Vapourtec R2/R4+ reactor unit, to prepare functionalized aryl–Mg compounds from aryl iodides and bromides (Figure 19). This study also showed how adopting a machine‐assisted flow approach was an effective system for managing highly exothermic reactions through fast mixing and efficient heat transfer.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). firstname.lastname@example.org.