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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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An R2/R4+ reactor system and FlowIR were combined to effectively manage organometallic reagents in continuous‐flow reactions.
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fig19: An R2/R4+ reactor system and FlowIR were combined to effectively manage organometallic reagents in continuous‐flow reactions.

Mentions: In 2012, our group made pioneering use of the Mettler–Toledo microscale ReactIR flow cell as an inline analytical tool to devise a new flow‐chemistry approach useful for the preparation of Grignard reagents that were not commercially available.83 We exemplified the strategy with a LiCl‐mediated halogen–Mg exchange reaction, performed using a Vapourtec R2/R4+ reactor unit, to prepare functionalized aryl–Mg compounds from aryl iodides and bromides (Figure 19). This study also showed how adopting a machine‐assisted flow approach was an effective system for managing highly exothermic reactions through fast mixing and efficient heat transfer.


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

An R2/R4+ reactor system and FlowIR were combined to effectively manage organometallic reagents in continuous‐flow reactions.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig19: An R2/R4+ reactor system and FlowIR were combined to effectively manage organometallic reagents in continuous‐flow reactions.
Mentions: In 2012, our group made pioneering use of the Mettler–Toledo microscale ReactIR flow cell as an inline analytical tool to devise a new flow‐chemistry approach useful for the preparation of Grignard reagents that were not commercially available.83 We exemplified the strategy with a LiCl‐mediated halogen–Mg exchange reaction, performed using a Vapourtec R2/R4+ reactor unit, to prepare functionalized aryl–Mg compounds from aryl iodides and bromides (Figure 19). This study also showed how adopting a machine‐assisted flow approach was an effective system for managing highly exothermic reactions through fast mixing and efficient heat transfer.

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus