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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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The efficiencies of five reactor configurations were tested: a) an immersed well, batch‐mode reactor; b) a recirculating annular reactor; c) a microfluidic single pass reactor; d) a microfluidic recirculating reactor; and e) a biphasic‐flow, single‐pass microfluidic system. Reprinted from Ref. 97 with permission. Copyright 2014, American Chemical Society.
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fig23: The efficiencies of five reactor configurations were tested: a) an immersed well, batch‐mode reactor; b) a recirculating annular reactor; c) a microfluidic single pass reactor; d) a microfluidic recirculating reactor; and e) a biphasic‐flow, single‐pass microfluidic system. Reprinted from Ref. 97 with permission. Copyright 2014, American Chemical Society.

Mentions: A recent study investigated the efficacy of five reactor designs for carrying out ene reactions with singlet oxygen. The systems tested (Figure 23) were chosen so as to give an insight into design parameters for photocatalyzed microreactors and were comprised of an immersed well reactor (batch mode), a recirculating annular reactor, and three microchip‐based reaction systems. It was found that the excellent mixing conditions and the large surface area to volume ratio inherent to the microreactor systems lead to more efficient product formation for the oxygenation of α‐pinene to pinocarvone.97


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

The efficiencies of five reactor configurations were tested: a) an immersed well, batch‐mode reactor; b) a recirculating annular reactor; c) a microfluidic single pass reactor; d) a microfluidic recirculating reactor; and e) a biphasic‐flow, single‐pass microfluidic system. Reprinted from Ref. 97 with permission. Copyright 2014, American Chemical Society.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig23: The efficiencies of five reactor configurations were tested: a) an immersed well, batch‐mode reactor; b) a recirculating annular reactor; c) a microfluidic single pass reactor; d) a microfluidic recirculating reactor; and e) a biphasic‐flow, single‐pass microfluidic system. Reprinted from Ref. 97 with permission. Copyright 2014, American Chemical Society.
Mentions: A recent study investigated the efficacy of five reactor designs for carrying out ene reactions with singlet oxygen. The systems tested (Figure 23) were chosen so as to give an insight into design parameters for photocatalyzed microreactors and were comprised of an immersed well reactor (batch mode), a recirculating annular reactor, and three microchip‐based reaction systems. It was found that the excellent mixing conditions and the large surface area to volume ratio inherent to the microreactor systems lead to more efficient product formation for the oxygenation of α‐pinene to pinocarvone.97

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus