Machine-Assisted Organic Synthesis.
Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). email@example.com.Show MeSH
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Mentions: Since this area has been recently reviewed, we will highlight just two alternative approaches for managing solids in flow. The first of these looks at common salt‐forming reactions, typified in the preparation of many active pharmaceutical ingredients (APIs), for example. In 2011 our group evaluated the use of a commercially available agitated cell reactor (Coflore ACR, Figure 17 a) in the formation of the hydroiodide salt of N‐iodomorpholine, which is a source of electrophilic iodine and thus a useful iodinating agent, through the reaction of morpholine with iodine (Figure 17 b).76
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). firstname.lastname@example.org.