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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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Related in: MedlinePlus

Continuous photo‐oxidation under supercritical CO2 conditions for the production of antimalarial trioxanes. A series of UV LEDs and sapphire reactors were used to expose the reagents to UV radiation.
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fig2: Continuous photo‐oxidation under supercritical CO2 conditions for the production of antimalarial trioxanes. A series of UV LEDs and sapphire reactors were used to expose the reagents to UV radiation.

Mentions: In one recent study, bespoke devices were used to conduct a continuous photo‐oxidation reaction for one of three steps in the synthesis of antimalarial trioxanes.13 An allylic alcohol was pumped with 5,10,15,20‐tetrakis(pentafluorophenyl)porphyrin (TPFPP) and a cyclic ketone (a cosolvent to solubilize the TPFPP and reagent in the next step) into a stream of CO2 and O2 before passing through two sapphire tube reactors in which the contents were irradiated with UV LEDs (Figure 2). A yield of 86 % of the product hydroperoxides was reported (an improvement over the batch process) with a syn selectivity of 85 %.


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Continuous photo‐oxidation under supercritical CO2 conditions for the production of antimalarial trioxanes. A series of UV LEDs and sapphire reactors were used to expose the reagents to UV radiation.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig2: Continuous photo‐oxidation under supercritical CO2 conditions for the production of antimalarial trioxanes. A series of UV LEDs and sapphire reactors were used to expose the reagents to UV radiation.
Mentions: In one recent study, bespoke devices were used to conduct a continuous photo‐oxidation reaction for one of three steps in the synthesis of antimalarial trioxanes.13 An allylic alcohol was pumped with 5,10,15,20‐tetrakis(pentafluorophenyl)porphyrin (TPFPP) and a cyclic ketone (a cosolvent to solubilize the TPFPP and reagent in the next step) into a stream of CO2 and O2 before passing through two sapphire tube reactors in which the contents were irradiated with UV LEDs (Figure 2). A yield of 86 % of the product hydroperoxides was reported (an improvement over the batch process) with a syn selectivity of 85 %.

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus