Machine-Assisted Organic Synthesis.
Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). firstname.lastname@example.org.Show MeSH
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Mentions: In one recent study, bespoke devices were used to conduct a continuous photo‐oxidation reaction for one of three steps in the synthesis of antimalarial trioxanes.13 An allylic alcohol was pumped with 5,10,15,20‐tetrakis(pentafluorophenyl)porphyrin (TPFPP) and a cyclic ketone (a cosolvent to solubilize the TPFPP and reagent in the next step) into a stream of CO2 and O2 before passing through two sapphire tube reactors in which the contents were irradiated with UV LEDs (Figure 2). A yield of 86 % of the product hydroperoxides was reported (an improvement over the batch process) with a syn selectivity of 85 %.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). email@example.com.