Machine-Assisted Organic Synthesis.
Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). email@example.com.Show MeSH
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Mentions: The use of a fluidized‐bed reactor for the photocatalytic formation of styrene from ethylbenzene over sulfated MoOx/γ‐Al2O3 has been reported.34 Ethylbenzene and water vapor were fed into a gaseous stream containing O2 and N2 by means of two temperature‐controlled saturators. This mixture was then pumped into a heated reaction chamber, in which solid particles of catalyst and silica were placed under illumination by UVA LED modules (Figure 6). The upwards gas movement in the reaction chamber served to fluidize the particle bed, thus causing turbulent flow and promoting excellent mixing between the gas and solid phases. This system configuration improved on the selectivity of the catalytic process, achieving 100 % selectivity under less harsh conditions than those reported previously.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). firstname.lastname@example.org.