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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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The performance of various equipment layouts was compared for a fluidized bed system. a) All gases were fed together into the reactor through one injection point. b) A two‐zone injection system with gaseous nitrogen and hydrogen streams fed from the base and benzene and oxygen fed from the top. c) A similar two‐zone injection system, but hydrogen and oxygen inputs were switched.
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fig7: The performance of various equipment layouts was compared for a fluidized bed system. a) All gases were fed together into the reactor through one injection point. b) A two‐zone injection system with gaseous nitrogen and hydrogen streams fed from the base and benzene and oxygen fed from the top. c) A similar two‐zone injection system, but hydrogen and oxygen inputs were switched.

Mentions: Another study investigated the important effects of reactor configuration on fluidized‐bed performance for the production of phenol from the oxidation of benzene.35 Three beds were tested: the first was a single‐zone, conventional fluidized‐bed reactor in which all the reactants were fed into the system simultaneously (Figure 7 a); the second was a two‐zone bed where N2 and H2 were fed into the base while benzene and O2 were fed in from the center (Figure 7 b); and the third was also a two‐zone bed, but the injection point of O2 and H2 were switched (Figure 7 c). The solid catalyst used in all cases was Pt‐VOx/SiO2. By adjusting the position of the gas injection in the two‐bed systems and thus the reaction selectivity, it was found that it was possible to form mixtures of phenol and cyclohexanone or cyclohexane of various compositions simply through the addition point. It was found that 100 % selectivity for the production of phenol could be obtained when the oxygen was injected at half‐bed height (Figure 7 b). It would not have been possible to evaluate all these dynamic parameters in static batch‐reactor systems.


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

The performance of various equipment layouts was compared for a fluidized bed system. a) All gases were fed together into the reactor through one injection point. b) A two‐zone injection system with gaseous nitrogen and hydrogen streams fed from the base and benzene and oxygen fed from the top. c) A similar two‐zone injection system, but hydrogen and oxygen inputs were switched.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig7: The performance of various equipment layouts was compared for a fluidized bed system. a) All gases were fed together into the reactor through one injection point. b) A two‐zone injection system with gaseous nitrogen and hydrogen streams fed from the base and benzene and oxygen fed from the top. c) A similar two‐zone injection system, but hydrogen and oxygen inputs were switched.
Mentions: Another study investigated the important effects of reactor configuration on fluidized‐bed performance for the production of phenol from the oxidation of benzene.35 Three beds were tested: the first was a single‐zone, conventional fluidized‐bed reactor in which all the reactants were fed into the system simultaneously (Figure 7 a); the second was a two‐zone bed where N2 and H2 were fed into the base while benzene and O2 were fed in from the center (Figure 7 b); and the third was also a two‐zone bed, but the injection point of O2 and H2 were switched (Figure 7 c). The solid catalyst used in all cases was Pt‐VOx/SiO2. By adjusting the position of the gas injection in the two‐bed systems and thus the reaction selectivity, it was found that it was possible to form mixtures of phenol and cyclohexanone or cyclohexane of various compositions simply through the addition point. It was found that 100 % selectivity for the production of phenol could be obtained when the oxygen was injected at half‐bed height (Figure 7 b). It would not have been possible to evaluate all these dynamic parameters in static batch‐reactor systems.

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus