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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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The various reactions carried out by Kim and co‐workers using a membrane microreactor to facilitate the generation and subsequent consumption of diazomethane.32
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fig5: The various reactions carried out by Kim and co‐workers using a membrane microreactor to facilitate the generation and subsequent consumption of diazomethane.32

Mentions: The use of gas‐permeable membranes has greatly increased safety when dealing with hazardous reagents, such as diazomethane. Through the in situ generation, transportation, and reaction of diazomethane (CH2N2) in a membrane‐based microreactor system (Figure 5), researchers were able to conduct a variety of methylation reactions without the need to maintain any quantity of CH2N2.32 A similar membrane system has also been reported by this group when carrying out catalytic Heck reactions with O2.33


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

The various reactions carried out by Kim and co‐workers using a membrane microreactor to facilitate the generation and subsequent consumption of diazomethane.32
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig5: The various reactions carried out by Kim and co‐workers using a membrane microreactor to facilitate the generation and subsequent consumption of diazomethane.32
Mentions: The use of gas‐permeable membranes has greatly increased safety when dealing with hazardous reagents, such as diazomethane. Through the in situ generation, transportation, and reaction of diazomethane (CH2N2) in a membrane‐based microreactor system (Figure 5), researchers were able to conduct a variety of methylation reactions without the need to maintain any quantity of CH2N2.32 A similar membrane system has also been reported by this group when carrying out catalytic Heck reactions with O2.33

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus