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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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Synthesis of nazlinine and unnatural congeners by a two‐step, electrocatalyzed and microwave process.
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fig20: Synthesis of nazlinine and unnatural congeners by a two‐step, electrocatalyzed and microwave process.

Mentions: Our group also recently reported how using a key electrochemical Shono oxidation in flow enabled efficient access to a number of unnatural analogues of the alkaloid nazlinine (Figure 20).91 The choice of incorporating electrochemistry in this instance, by using a commercially available unit (Figure 21), meant substoichiometric loadings of electrolyte (20 mol %) were sufficient to effect the necessary reactions.


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Synthesis of nazlinine and unnatural congeners by a two‐step, electrocatalyzed and microwave process.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig20: Synthesis of nazlinine and unnatural congeners by a two‐step, electrocatalyzed and microwave process.
Mentions: Our group also recently reported how using a key electrochemical Shono oxidation in flow enabled efficient access to a number of unnatural analogues of the alkaloid nazlinine (Figure 20).91 The choice of incorporating electrochemistry in this instance, by using a commercially available unit (Figure 21), meant substoichiometric loadings of electrolyte (20 mol %) were sufficient to effect the necessary reactions.

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus