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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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a) Annular, tube‐in‐tube fluid‐flow regions. The semipermeable membrane tubing is placed inside an impermeable PTFE outer layer. b) Prototype reactor used to facilitate gas–liquid reactions.27 Reproduced with permission from The Royal Society of Chemistry. c) The Gastropod reactor from Cambridge Reactor Design, a commercially available unit that was developed from this study.29
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fig4: a) Annular, tube‐in‐tube fluid‐flow regions. The semipermeable membrane tubing is placed inside an impermeable PTFE outer layer. b) Prototype reactor used to facilitate gas–liquid reactions.27 Reproduced with permission from The Royal Society of Chemistry. c) The Gastropod reactor from Cambridge Reactor Design, a commercially available unit that was developed from this study.29

Mentions: In 2010, our group developed a novel reactor design which facilitated gas–liquid contact in pressurized systems through the use of a semipermeable membrane made from teflon AF‐2400.18 Early designs were based on the membrane being placed into a pressurized reaction chamber in which a large volume of gas was present. Having such a large dead‐volume of reactive gas present is undesirable when carrying out reactions using hazardous gases such as ozone. As such, the reactor configuration was modified to resemble a tube‐in‐tube system, where membrane piping was placed inside tubing material of a larger diameter. In this case, solution was pumped through the center of the inner pipe while pressurized gas was pumped through the annular region between the membrane and outer tubing or vice versa (Figure 4). By doing so, the volume of gas within the reactor is greatly minimized, thereby mitigating any safety risks.


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

a) Annular, tube‐in‐tube fluid‐flow regions. The semipermeable membrane tubing is placed inside an impermeable PTFE outer layer. b) Prototype reactor used to facilitate gas–liquid reactions.27 Reproduced with permission from The Royal Society of Chemistry. c) The Gastropod reactor from Cambridge Reactor Design, a commercially available unit that was developed from this study.29
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig4: a) Annular, tube‐in‐tube fluid‐flow regions. The semipermeable membrane tubing is placed inside an impermeable PTFE outer layer. b) Prototype reactor used to facilitate gas–liquid reactions.27 Reproduced with permission from The Royal Society of Chemistry. c) The Gastropod reactor from Cambridge Reactor Design, a commercially available unit that was developed from this study.29
Mentions: In 2010, our group developed a novel reactor design which facilitated gas–liquid contact in pressurized systems through the use of a semipermeable membrane made from teflon AF‐2400.18 Early designs were based on the membrane being placed into a pressurized reaction chamber in which a large volume of gas was present. Having such a large dead‐volume of reactive gas present is undesirable when carrying out reactions using hazardous gases such as ozone. As such, the reactor configuration was modified to resemble a tube‐in‐tube system, where membrane piping was placed inside tubing material of a larger diameter. In this case, solution was pumped through the center of the inner pipe while pressurized gas was pumped through the annular region between the membrane and outer tubing or vice versa (Figure 4). By doing so, the volume of gas within the reactor is greatly minimized, thereby mitigating any safety risks.

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus