Machine-Assisted Organic Synthesis.
Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). firstname.lastname@example.org.Show MeSH
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Mentions: In contrast to the transverse mode of operation of the above‐described Coflore ACR, another interesting approach has been the development of the multijet oscillating disc microreactor (MJOD, Figure 18), a device specifically developed for flow chemistry on a milliscale.78 The MJOD is fitted with an adjustable amplitude and frequency oscillator that moves the multijet reactor tube of the disc assembly forward and backward in the longitudinal (axial) direction of the reactor, analogous to a piston engine with multiple piston heads on a single piston shaft. Each piston head (the discs) is furnished with several jets. Some 60–100 perforated discs are fixed at equal distances on the shaft of the MJOD unit. Reactants, introduced through inlet lines fitted with one‐way valves, are forced through at high pressure through the perforations. As the spray enters the reaction chamber the flow rate decreases, which promotes the formation of vortices, thus resulting in enhanced mixing.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). email@example.com.