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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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Expanded view of the Polar Bear Plus from Cambridge Reactor Design showing the refrigeration loops and other key components.29
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fig9: Expanded view of the Polar Bear Plus from Cambridge Reactor Design showing the refrigeration loops and other key components.29

Mentions: Further developments to the “Polar Bear” yielded a second‐generation device (the “Polar Bear Plus”, Figure 9) with which it was possible to accurately maintain conditions over a wider range of temperatures: from −40 °C to +150 °C.41 By using miniaturized compressors it was possible to reduce the size of this device by over 89 % and its weight from 65 kg to 12 kg. The modular nature of the heating and cooling plate in this system enables the unit to be used for batch and flow reactions, as well as continuous stirred tank reactor (CSTR) systems. Our group has used this device for the preparation of thiourea using a tube‐in‐tube gas coil configuration with ammonia and for the continuous telescoped flow synthesis of fanetizole.22


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Expanded view of the Polar Bear Plus from Cambridge Reactor Design showing the refrigeration loops and other key components.29
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig9: Expanded view of the Polar Bear Plus from Cambridge Reactor Design showing the refrigeration loops and other key components.29
Mentions: Further developments to the “Polar Bear” yielded a second‐generation device (the “Polar Bear Plus”, Figure 9) with which it was possible to accurately maintain conditions over a wider range of temperatures: from −40 °C to +150 °C.41 By using miniaturized compressors it was possible to reduce the size of this device by over 89 % and its weight from 65 kg to 12 kg. The modular nature of the heating and cooling plate in this system enables the unit to be used for batch and flow reactions, as well as continuous stirred tank reactor (CSTR) systems. Our group has used this device for the preparation of thiourea using a tube‐in‐tube gas coil configuration with ammonia and for the continuous telescoped flow synthesis of fanetizole.22

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus