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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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Preparation of the natural product grossamide by using immobilized horseradish peroxidase.
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fig13: Preparation of the natural product grossamide by using immobilized horseradish peroxidase.

Mentions: In an early example from our own laboratories, we showed that a ferulic acid amide (prepared by flow equipment), when detected in‐line by UV/Vis monitoring, can be passed onto a cartridge containing immobilized horseradish peroxidase to effect a dimerization to the natural product grossamide (Figure 13). This process forms a new C—O and a C—C bond, which we were unable to forge using traditional reagents.63 The enzyme was recycled by co‐flowing H2O2/urea complex and sodium dihydrogen phosphate buffer in acetone/water (1:4).


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Preparation of the natural product grossamide by using immobilized horseradish peroxidase.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig13: Preparation of the natural product grossamide by using immobilized horseradish peroxidase.
Mentions: In an early example from our own laboratories, we showed that a ferulic acid amide (prepared by flow equipment), when detected in‐line by UV/Vis monitoring, can be passed onto a cartridge containing immobilized horseradish peroxidase to effect a dimerization to the natural product grossamide (Figure 13). This process forms a new C—O and a C—C bond, which we were unable to forge using traditional reagents.63 The enzyme was recycled by co‐flowing H2O2/urea complex and sodium dihydrogen phosphate buffer in acetone/water (1:4).

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus