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Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer.

Lee JH, Son MW, Kim KJ, Oh MH, Cho H, Lee HJ, Jang SH, Lee MS - J Gastric Cancer (2016)

Bottom Line: The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P<0.001), early pathologic T-stage (P=0.012), and early American Joint Committee on Cancer stage (P=0.022).In the Kaplan-Meier analysis, the TLE1 expression was significantly associated with longer disease-free (P=0.022) and overall (P=0.001) survival rates.We suggested that TLE1 expression is a good prognostic indicator in GCs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

ABSTRACT

Purpose: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the tumorigenesis of various tumors. We investigated the prognostic significance of TLE1 expression and its association with clinicopathological parameters in gastric cancer (GC) patients.

Materials and methods: Immunohistochemical analysis of six tissue microarrays was performed to examine TLE1 expression using 291 surgically resected GC specimens from the Soonchunhyang University Cheonan Hospital between July 2006 and December 2009.

Results: In the non-neoplastic gastric mucosa, TLE1 expression was negative. In GC, 121 patients (41.6%) were positive for TLE1. The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P<0.001), early pathologic T-stage (P=0.012), and early American Joint Committee on Cancer stage (P=0.022). In the Kaplan-Meier analysis, the TLE1 expression was significantly associated with longer disease-free (P=0.022) and overall (P=0.001) survival rates.

Conclusions: We suggested that TLE1 expression is a good prognostic indicator in GCs.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier survival analysis with log-rank test. Transducer-like enhancer of split 1 expression was significantly associated with good overall survival (A) and good disease-free survival (B).
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Figure 2: Kaplan-Meier survival analysis with log-rank test. Transducer-like enhancer of split 1 expression was significantly associated with good overall survival (A) and good disease-free survival (B).

Mentions: The follow-up duration across the patient cohort ranged from 1 to 95 months (median duration of DFS, 56 months; OS, 65 months). During follow-up, four patients (1.4%) had local recurrence and 46 patients (15.8%) had distant metastases. In addition, 68 patients (23.4%) died. According to the Kaplan-Meier analysis, TLE1 expression was significantly associated with longer DFS (P=0.022) and OS rates (P=0.001) (Fig. 2). Additionally, male gender, lymphatic or perineural invasion, poor histologic grade, more advanced pathologic T/N stages, and more advanced AJCC stages were significantly associated with shorter DFS (P<0.05) and OS rates (P<0.05). In the multivariate Cox regression analysis, TLE1 expression was not significantly associated with survival (data not shown).


Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer.

Lee JH, Son MW, Kim KJ, Oh MH, Cho H, Lee HJ, Jang SH, Lee MS - J Gastric Cancer (2016)

Kaplan-Meier survival analysis with log-rank test. Transducer-like enhancer of split 1 expression was significantly associated with good overall survival (A) and good disease-free survival (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834617&req=5

Figure 2: Kaplan-Meier survival analysis with log-rank test. Transducer-like enhancer of split 1 expression was significantly associated with good overall survival (A) and good disease-free survival (B).
Mentions: The follow-up duration across the patient cohort ranged from 1 to 95 months (median duration of DFS, 56 months; OS, 65 months). During follow-up, four patients (1.4%) had local recurrence and 46 patients (15.8%) had distant metastases. In addition, 68 patients (23.4%) died. According to the Kaplan-Meier analysis, TLE1 expression was significantly associated with longer DFS (P=0.022) and OS rates (P=0.001) (Fig. 2). Additionally, male gender, lymphatic or perineural invasion, poor histologic grade, more advanced pathologic T/N stages, and more advanced AJCC stages were significantly associated with shorter DFS (P<0.05) and OS rates (P<0.05). In the multivariate Cox regression analysis, TLE1 expression was not significantly associated with survival (data not shown).

Bottom Line: The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P<0.001), early pathologic T-stage (P=0.012), and early American Joint Committee on Cancer stage (P=0.022).In the Kaplan-Meier analysis, the TLE1 expression was significantly associated with longer disease-free (P=0.022) and overall (P=0.001) survival rates.We suggested that TLE1 expression is a good prognostic indicator in GCs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

ABSTRACT

Purpose: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the tumorigenesis of various tumors. We investigated the prognostic significance of TLE1 expression and its association with clinicopathological parameters in gastric cancer (GC) patients.

Materials and methods: Immunohistochemical analysis of six tissue microarrays was performed to examine TLE1 expression using 291 surgically resected GC specimens from the Soonchunhyang University Cheonan Hospital between July 2006 and December 2009.

Results: In the non-neoplastic gastric mucosa, TLE1 expression was negative. In GC, 121 patients (41.6%) were positive for TLE1. The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P<0.001), early pathologic T-stage (P=0.012), and early American Joint Committee on Cancer stage (P=0.022). In the Kaplan-Meier analysis, the TLE1 expression was significantly associated with longer disease-free (P=0.022) and overall (P=0.001) survival rates.

Conclusions: We suggested that TLE1 expression is a good prognostic indicator in GCs.

No MeSH data available.


Related in: MedlinePlus