Limits...
Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

Walsh C, Bonner JJ, Johnson TN, Neuhoff S, Ghazaly EA, Gribben JG, Boddy AV, Veal GJ - Br J Clin Pharmacol (2016)

Bottom Line: Simulated values for actinomycin D AUC0-26h and clearance in infants aged 0-12 months ranged from 104 to 115 ng h ml(-1) and 3.5-3.8 l h(-1) , respectively.However, additional independent data from neonates and infants is needed for further validation.Physiological differences between paediatric cancer patients and healthy children also need to be further characterized and incorporated into PBPK models.

View Article: PubMed Central - PubMed

Affiliation: Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.

No MeSH data available.


Related in: MedlinePlus

Standard curve of compounds with known Log P values. From left to right, the compounds are: 4‐methoxyphenol, m‐cresol, 1‐naphthol, thymol, diphenyl ether
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4834588&req=5

bcp12878-fig-0001: Standard curve of compounds with known Log P values. From left to right, the compounds are: 4‐methoxyphenol, m‐cresol, 1‐naphthol, thymol, diphenyl ether

Mentions: Table 3 provides a summary of the results obtained. As shown in Figure 1, a correlation was determined between Log k and the known Log P values for the standards, and the Log P of Act D was extrapolated from the standard curve obtained. The Log P values for the standard compounds when determined by interpolation of the standard curve were all within 30% of their published values. The Log P of Act D was calculated as 4.47 (Table 2).


Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

Walsh C, Bonner JJ, Johnson TN, Neuhoff S, Ghazaly EA, Gribben JG, Boddy AV, Veal GJ - Br J Clin Pharmacol (2016)

Standard curve of compounds with known Log P values. From left to right, the compounds are: 4‐methoxyphenol, m‐cresol, 1‐naphthol, thymol, diphenyl ether
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834588&req=5

bcp12878-fig-0001: Standard curve of compounds with known Log P values. From left to right, the compounds are: 4‐methoxyphenol, m‐cresol, 1‐naphthol, thymol, diphenyl ether
Mentions: Table 3 provides a summary of the results obtained. As shown in Figure 1, a correlation was determined between Log k and the known Log P values for the standards, and the Log P of Act D was extrapolated from the standard curve obtained. The Log P values for the standard compounds when determined by interpolation of the standard curve were all within 30% of their published values. The Log P of Act D was calculated as 4.47 (Table 2).

Bottom Line: Simulated values for actinomycin D AUC0-26h and clearance in infants aged 0-12 months ranged from 104 to 115 ng h ml(-1) and 3.5-3.8 l h(-1) , respectively.However, additional independent data from neonates and infants is needed for further validation.Physiological differences between paediatric cancer patients and healthy children also need to be further characterized and incorporated into PBPK models.

View Article: PubMed Central - PubMed

Affiliation: Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.

No MeSH data available.


Related in: MedlinePlus