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Controlled water vapor transmission rate promotes wound-healing via wound re-epithelialization and contraction enhancement.

Xu R, Xia H, He W, Li Z, Zhao J, Liu B, Wang Y, Lei Q, Kong Y, Bai Y, Yao Z, Yan R, Li H, Zhan R, Yang S, Luo G, Wu J - Sci Rep (2016)

Bottom Line: Here, we prepared serial polyurethane (PU) membrane dressings with graded water vapor transmission rates (WVTRs), and the optimal WVTR of the dressing for wound healing was identified by both in vitro and in vivo studies.It was found that the dressing with a WVTR of 2028.3 ± 237.8 g/m(2)·24 h was able to maintain an optimal moisture content for the proliferation and regular function of epidermal cells and fibroblasts in a three-dimensional culture model.Moreover, the dressing with this optimal WTVR was found to be able to promote wound healing in a mouse skin wound model.

View Article: PubMed Central - PubMed

Affiliation: Institute of Burn Research, Southwest Hospital; State Key Lab of Trauma, Burn and Combined Injury; Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University, Chongqing 400038, China.

ABSTRACT
A desirable microenvironment is essential for wound healing, in which an ideal moisture content is one of the most important factors. The fundamental function and requirement for wound dressings is to keep the wound at an optimal moisture. Here, we prepared serial polyurethane (PU) membrane dressings with graded water vapor transmission rates (WVTRs), and the optimal WVTR of the dressing for wound healing was identified by both in vitro and in vivo studies. It was found that the dressing with a WVTR of 2028.3 ± 237.8 g/m(2)·24 h was able to maintain an optimal moisture content for the proliferation and regular function of epidermal cells and fibroblasts in a three-dimensional culture model. Moreover, the dressing with this optimal WTVR was found to be able to promote wound healing in a mouse skin wound model. Our finds may be helpful in the design of wound dressing for wound regeneration in the future.

No MeSH data available.


Related in: MedlinePlus

Wound healing experiment.(a) The macroscopic appearance of the wounds postsurgery in the six groups at different time-points. (b) A three-dimensional diagram of wound healing. (c) The rates of wound contraction at different times. The values were calculated as the mean ± SD (n = 5), **p < 0.01, *p < 0.05. Wound healing was observed to accelerate when the MP-PU was applied.
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f4: Wound healing experiment.(a) The macroscopic appearance of the wounds postsurgery in the six groups at different time-points. (b) A three-dimensional diagram of wound healing. (c) The rates of wound contraction at different times. The values were calculated as the mean ± SD (n = 5), **p < 0.01, *p < 0.05. Wound healing was observed to accelerate when the MP-PU was applied.

Mentions: In the mouse wound healing model, wound healing in the MP group was enhanced compared with that in the blank, EHP, HP, LP and ELP groups. As shown in Fig. 4a, the macroscopic appearance of wounds at different times post-wounding were quite different. Wounds in the blank and EHP groups were dehydrated, and scabs formed. Conversely, exudates were observed in the LP and ELP groups. In contrast, the wounds in the MP and HP groups appeared to be clean and moist, especially in the MP group.


Controlled water vapor transmission rate promotes wound-healing via wound re-epithelialization and contraction enhancement.

Xu R, Xia H, He W, Li Z, Zhao J, Liu B, Wang Y, Lei Q, Kong Y, Bai Y, Yao Z, Yan R, Li H, Zhan R, Yang S, Luo G, Wu J - Sci Rep (2016)

Wound healing experiment.(a) The macroscopic appearance of the wounds postsurgery in the six groups at different time-points. (b) A three-dimensional diagram of wound healing. (c) The rates of wound contraction at different times. The values were calculated as the mean ± SD (n = 5), **p < 0.01, *p < 0.05. Wound healing was observed to accelerate when the MP-PU was applied.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834567&req=5

f4: Wound healing experiment.(a) The macroscopic appearance of the wounds postsurgery in the six groups at different time-points. (b) A three-dimensional diagram of wound healing. (c) The rates of wound contraction at different times. The values were calculated as the mean ± SD (n = 5), **p < 0.01, *p < 0.05. Wound healing was observed to accelerate when the MP-PU was applied.
Mentions: In the mouse wound healing model, wound healing in the MP group was enhanced compared with that in the blank, EHP, HP, LP and ELP groups. As shown in Fig. 4a, the macroscopic appearance of wounds at different times post-wounding were quite different. Wounds in the blank and EHP groups were dehydrated, and scabs formed. Conversely, exudates were observed in the LP and ELP groups. In contrast, the wounds in the MP and HP groups appeared to be clean and moist, especially in the MP group.

Bottom Line: Here, we prepared serial polyurethane (PU) membrane dressings with graded water vapor transmission rates (WVTRs), and the optimal WVTR of the dressing for wound healing was identified by both in vitro and in vivo studies.It was found that the dressing with a WVTR of 2028.3 ± 237.8 g/m(2)·24 h was able to maintain an optimal moisture content for the proliferation and regular function of epidermal cells and fibroblasts in a three-dimensional culture model.Moreover, the dressing with this optimal WTVR was found to be able to promote wound healing in a mouse skin wound model.

View Article: PubMed Central - PubMed

Affiliation: Institute of Burn Research, Southwest Hospital; State Key Lab of Trauma, Burn and Combined Injury; Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University, Chongqing 400038, China.

ABSTRACT
A desirable microenvironment is essential for wound healing, in which an ideal moisture content is one of the most important factors. The fundamental function and requirement for wound dressings is to keep the wound at an optimal moisture. Here, we prepared serial polyurethane (PU) membrane dressings with graded water vapor transmission rates (WVTRs), and the optimal WVTR of the dressing for wound healing was identified by both in vitro and in vivo studies. It was found that the dressing with a WVTR of 2028.3 ± 237.8 g/m(2)·24 h was able to maintain an optimal moisture content for the proliferation and regular function of epidermal cells and fibroblasts in a three-dimensional culture model. Moreover, the dressing with this optimal WTVR was found to be able to promote wound healing in a mouse skin wound model. Our finds may be helpful in the design of wound dressing for wound regeneration in the future.

No MeSH data available.


Related in: MedlinePlus