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Hydrothermal synthesis of NiWO4 crystals for high performance non-enzymatic glucose biosensors.

Mani S, Vediyappan V, Chen SM, Madhu R, Pitchaimani V, Chang JY, Liu SB - Sci Rep (2016)

Bottom Line: A facile hydrothermal route for the synthesis of ordered NiWO4 nanocrystals, which show promising applications as high performance non-enzymatic glucose sensor is reported.The NiWO4-modified electrodes showed excellent sensitivity (269.6 μA mM(-1 )cm(-2)) and low detection limit (0.18 μM) for detection of glucose with desirable selectivity, stability, and tolerance to interference, rendering their prospective applications as cost-effective, enzyme-free glucose sensors.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.

ABSTRACT
A facile hydrothermal route for the synthesis of ordered NiWO4 nanocrystals, which show promising applications as high performance non-enzymatic glucose sensor is reported. The NiWO4-modified electrodes showed excellent sensitivity (269.6 μA mM(-1 )cm(-2)) and low detection limit (0.18 μM) for detection of glucose with desirable selectivity, stability, and tolerance to interference, rendering their prospective applications as cost-effective, enzyme-free glucose sensors.

No MeSH data available.


Related in: MedlinePlus

Amperometric response of NiWO4-modified GCE (A) under successive addition of glucose within the total concentration range from 0.006 μM to 4.1 mM; insets: (upper) corresponding calibration plot of peak current vs glucose concentration, (lower) blow-up response curve, and (B) obtained from anti-inference studies under the sequential influence of glucose and electroactive interferences (100 μM), viz. serum (30 μL), serum and glucose, AA, and UA. All measurements were conducted under the conditions: supporting electrolytes, 0.1 M NaOH aqueous solutions; rpm, 1200; applied potential, 0.55 V.
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f6: Amperometric response of NiWO4-modified GCE (A) under successive addition of glucose within the total concentration range from 0.006 μM to 4.1 mM; insets: (upper) corresponding calibration plot of peak current vs glucose concentration, (lower) blow-up response curve, and (B) obtained from anti-inference studies under the sequential influence of glucose and electroactive interferences (100 μM), viz. serum (30 μL), serum and glucose, AA, and UA. All measurements were conducted under the conditions: supporting electrolytes, 0.1 M NaOH aqueous solutions; rpm, 1200; applied potential, 0.55 V.

Mentions: To evaluate the sensitivity and selectivity of the proposed glucose sensor, we performed amperometric I-t study using the NiWO4-modified GCE as the rotating disc electrode. Figure 6A shows the corresponding amperometric response during successive addition of glucose recorded in 0.1 M NaOH electrolyte solution at an applied potential of +0.55 V. Clearly, a linear correlation between the oxidation peak current and total glucose concentration (from 0.006 μM to 4.1 mM) may be inferred (inset, Fig. 6A). Accordingly, ca. lower detection limit (LOD) was 0.18 μM according to the formula LOD = 3 sb/S (where sb is the standard deviation of the blank signal, and S is the sensitivity), the obtained sensitivity of the glucose sensor was derived to be 269.6 μA mM−1 cm−2, surpassing most Ni-based composite GCEs reported in literatures (see Table S1; SI).


Hydrothermal synthesis of NiWO4 crystals for high performance non-enzymatic glucose biosensors.

Mani S, Vediyappan V, Chen SM, Madhu R, Pitchaimani V, Chang JY, Liu SB - Sci Rep (2016)

Amperometric response of NiWO4-modified GCE (A) under successive addition of glucose within the total concentration range from 0.006 μM to 4.1 mM; insets: (upper) corresponding calibration plot of peak current vs glucose concentration, (lower) blow-up response curve, and (B) obtained from anti-inference studies under the sequential influence of glucose and electroactive interferences (100 μM), viz. serum (30 μL), serum and glucose, AA, and UA. All measurements were conducted under the conditions: supporting electrolytes, 0.1 M NaOH aqueous solutions; rpm, 1200; applied potential, 0.55 V.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834566&req=5

f6: Amperometric response of NiWO4-modified GCE (A) under successive addition of glucose within the total concentration range from 0.006 μM to 4.1 mM; insets: (upper) corresponding calibration plot of peak current vs glucose concentration, (lower) blow-up response curve, and (B) obtained from anti-inference studies under the sequential influence of glucose and electroactive interferences (100 μM), viz. serum (30 μL), serum and glucose, AA, and UA. All measurements were conducted under the conditions: supporting electrolytes, 0.1 M NaOH aqueous solutions; rpm, 1200; applied potential, 0.55 V.
Mentions: To evaluate the sensitivity and selectivity of the proposed glucose sensor, we performed amperometric I-t study using the NiWO4-modified GCE as the rotating disc electrode. Figure 6A shows the corresponding amperometric response during successive addition of glucose recorded in 0.1 M NaOH electrolyte solution at an applied potential of +0.55 V. Clearly, a linear correlation between the oxidation peak current and total glucose concentration (from 0.006 μM to 4.1 mM) may be inferred (inset, Fig. 6A). Accordingly, ca. lower detection limit (LOD) was 0.18 μM according to the formula LOD = 3 sb/S (where sb is the standard deviation of the blank signal, and S is the sensitivity), the obtained sensitivity of the glucose sensor was derived to be 269.6 μA mM−1 cm−2, surpassing most Ni-based composite GCEs reported in literatures (see Table S1; SI).

Bottom Line: A facile hydrothermal route for the synthesis of ordered NiWO4 nanocrystals, which show promising applications as high performance non-enzymatic glucose sensor is reported.The NiWO4-modified electrodes showed excellent sensitivity (269.6 μA mM(-1 )cm(-2)) and low detection limit (0.18 μM) for detection of glucose with desirable selectivity, stability, and tolerance to interference, rendering their prospective applications as cost-effective, enzyme-free glucose sensors.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.

ABSTRACT
A facile hydrothermal route for the synthesis of ordered NiWO4 nanocrystals, which show promising applications as high performance non-enzymatic glucose sensor is reported. The NiWO4-modified electrodes showed excellent sensitivity (269.6 μA mM(-1 )cm(-2)) and low detection limit (0.18 μM) for detection of glucose with desirable selectivity, stability, and tolerance to interference, rendering their prospective applications as cost-effective, enzyme-free glucose sensors.

No MeSH data available.


Related in: MedlinePlus