Limits...
Effect of Light Scattering and Higher-order Aberrations on Visual Performance in Eyes with Granular Corneal Dystrophy.

Kamiya K, Kobashi H, Igarashi A, Shoji N, Shimizu K - Sci Rep (2016)

Bottom Line: We retrospectively examined forty two eyes of 42 consecutive patients who diagnosed GCD, and age-matched 20 eyes of 20 healthy subjects.Intraocular forward scattering, corneal backward scattering, and corneal HOAs in eyes with GCD were higher than that in normal eyes.The CDVA was significantly correlated with intraocular forward scattering, but not with corneal HOAs in eyes with GCD, suggesting that light scattering, especially forward scattering, plays a more vital role in visual performance than corneal aberrations in eyes with GCD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Kitasato School of Medicine, Japan.

ABSTRACT
This study was aimed to assess the relationship of intraocular forward scattering, corneal backward scattering, and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) in eyes with granular corneal dystrophy (GCD). We retrospectively examined forty two eyes of 42 consecutive patients who diagnosed GCD, and age-matched 20 eyes of 20 healthy subjects. We assessed objective scattering index (OSI) using the double-pass instrument (OQAS II, Visiometrics), corneal densitometry (CD) using the Scheimpflug rotating camera (Pentacam HR, Oculus), and corneal HOAs using the Hartmann-Shack aberrometry (KR-9000, Topcon). The OSI, CD, and corneal HOAs were significantly larger in the GCD group than those in the control group (Mann-Whitney U test, p < 0.001). We found significant correlations of logMAR CDVA with the OSI (Spearman correlation coefficient r = 0.577, p < 0.001), and with the CD (r = 0.340, p = 0.028), but no significant association with corneal HOAs (r = 0.061, p = 0.701). Intraocular forward scattering, corneal backward scattering, and corneal HOAs in eyes with GCD were higher than that in normal eyes. The CDVA was significantly correlated with intraocular forward scattering, but not with corneal HOAs in eyes with GCD, suggesting that light scattering, especially forward scattering, plays a more vital role in visual performance than corneal aberrations in eyes with GCD.

No MeSH data available.


Related in: MedlinePlus

A graph showing a significant correlation between logarithm of the minimal angle of resolution corrected distance visual acuity and corneal densitometry (Spearman correlation coefficient r = 0.340, p = 0.028).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4834530&req=5

f2: A graph showing a significant correlation between logarithm of the minimal angle of resolution corrected distance visual acuity and corneal densitometry (Spearman correlation coefficient r = 0.340, p = 0.028).

Mentions: The patient demographics of the study population are listed in Table 1. The mean objective scattering index (OSI), corneal densitometry (CD), corneal HOAs, and logarithm of the minimal angle of resolution (logMAR) CDVA were 6.91 ± 2.72, 33.56 ± 3.72 GSU, 0.51 ± 0.21 μm, and 0.31 ± 0.20, respectively, in the GCD group. The corresponding figures were 1.53 ± 0.91, 18.70 ± 1.54 GSU, 0.19 ± 0.11 μm, and −0.11 ± 0.06, respectively, in the control group. We found significant differences in OSI, CD, corneal HOAs, or logMAR CDVA between the two groups (Mann-Whitney U test, p < 0.001). We found significant correlations of logMAR CDVA with the OSI (Spearman correlation coefficient r = 0.577, p < 0.001)(Fig. 1), and with the CD (r = 0.340, p = 0.028) in the GCD group (Fig. 2). On the other hand, we found no significant association of logMAR CDVA with corneal HOAs in the GCD group (r = 0.061, p = 0.701) (Fig. 3).


Effect of Light Scattering and Higher-order Aberrations on Visual Performance in Eyes with Granular Corneal Dystrophy.

Kamiya K, Kobashi H, Igarashi A, Shoji N, Shimizu K - Sci Rep (2016)

A graph showing a significant correlation between logarithm of the minimal angle of resolution corrected distance visual acuity and corneal densitometry (Spearman correlation coefficient r = 0.340, p = 0.028).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834530&req=5

f2: A graph showing a significant correlation between logarithm of the minimal angle of resolution corrected distance visual acuity and corneal densitometry (Spearman correlation coefficient r = 0.340, p = 0.028).
Mentions: The patient demographics of the study population are listed in Table 1. The mean objective scattering index (OSI), corneal densitometry (CD), corneal HOAs, and logarithm of the minimal angle of resolution (logMAR) CDVA were 6.91 ± 2.72, 33.56 ± 3.72 GSU, 0.51 ± 0.21 μm, and 0.31 ± 0.20, respectively, in the GCD group. The corresponding figures were 1.53 ± 0.91, 18.70 ± 1.54 GSU, 0.19 ± 0.11 μm, and −0.11 ± 0.06, respectively, in the control group. We found significant differences in OSI, CD, corneal HOAs, or logMAR CDVA between the two groups (Mann-Whitney U test, p < 0.001). We found significant correlations of logMAR CDVA with the OSI (Spearman correlation coefficient r = 0.577, p < 0.001)(Fig. 1), and with the CD (r = 0.340, p = 0.028) in the GCD group (Fig. 2). On the other hand, we found no significant association of logMAR CDVA with corneal HOAs in the GCD group (r = 0.061, p = 0.701) (Fig. 3).

Bottom Line: We retrospectively examined forty two eyes of 42 consecutive patients who diagnosed GCD, and age-matched 20 eyes of 20 healthy subjects.Intraocular forward scattering, corneal backward scattering, and corneal HOAs in eyes with GCD were higher than that in normal eyes.The CDVA was significantly correlated with intraocular forward scattering, but not with corneal HOAs in eyes with GCD, suggesting that light scattering, especially forward scattering, plays a more vital role in visual performance than corneal aberrations in eyes with GCD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Kitasato School of Medicine, Japan.

ABSTRACT
This study was aimed to assess the relationship of intraocular forward scattering, corneal backward scattering, and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) in eyes with granular corneal dystrophy (GCD). We retrospectively examined forty two eyes of 42 consecutive patients who diagnosed GCD, and age-matched 20 eyes of 20 healthy subjects. We assessed objective scattering index (OSI) using the double-pass instrument (OQAS II, Visiometrics), corneal densitometry (CD) using the Scheimpflug rotating camera (Pentacam HR, Oculus), and corneal HOAs using the Hartmann-Shack aberrometry (KR-9000, Topcon). The OSI, CD, and corneal HOAs were significantly larger in the GCD group than those in the control group (Mann-Whitney U test, p < 0.001). We found significant correlations of logMAR CDVA with the OSI (Spearman correlation coefficient r = 0.577, p < 0.001), and with the CD (r = 0.340, p = 0.028), but no significant association with corneal HOAs (r = 0.061, p = 0.701). Intraocular forward scattering, corneal backward scattering, and corneal HOAs in eyes with GCD were higher than that in normal eyes. The CDVA was significantly correlated with intraocular forward scattering, but not with corneal HOAs in eyes with GCD, suggesting that light scattering, especially forward scattering, plays a more vital role in visual performance than corneal aberrations in eyes with GCD.

No MeSH data available.


Related in: MedlinePlus