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Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression.

Papmeyer M, Sussmann JE, Stewart T, Giles S, Centola JG, Zannias V, Lawrie SM, Whalley HC, McIntosh AM - Psychiatry Res (2015)

Bottom Line: Additionally, no significant differences emerged between groups over time.Our results indicate that volumetric subcortical brain abnormalities of these regions using the current method appear not to form familial trait markers for vulnerability to mood disorders in close relatives of bipolar disorder patients over the two-year time period studied.Moreover, they do not appear to reduce in response to illness onset at least for the time period studied.

View Article: PubMed Central - PubMed

Affiliation: Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, United Kingdom; Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: martina.papmeyer@puk.unibe.ch.

No MeSH data available.


Related in: MedlinePlus

Subcortical regions of interest. Three-dimensional representation of the subcortical regions of interest extracted with FreeSurfer. Not shown: amygdala. Abbreviations: Ca, caudate; Hi, hippocampus; Lv, lateral ventricles; Pa, pallidum; Pu, putamen; Th, thalamus.
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f0005: Subcortical regions of interest. Three-dimensional representation of the subcortical regions of interest extracted with FreeSurfer. Not shown: amygdala. Abbreviations: Ca, caudate; Hi, hippocampus; Lv, lateral ventricles; Pa, pallidum; Pu, putamen; Th, thalamus.

Mentions: The following regions of interest (ROI) were extracted for each hemisphere (Fig. 1): lateral ventricles, caudate, putamen, pallidum, hippocampus, thalamus, amygdala. We decided to compare the volumes of these subcortical brain regions separately for each hemisphere since some findings in unaffected relatives of BD patients or first-episode MDD patients point towards specific lateralisation effects (Frodl et al., 2002, Nery et al., 2013). In addition, intra-cranial volume of the whole brain was extracted to serve as a covariate.


Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression.

Papmeyer M, Sussmann JE, Stewart T, Giles S, Centola JG, Zannias V, Lawrie SM, Whalley HC, McIntosh AM - Psychiatry Res (2015)

Subcortical regions of interest. Three-dimensional representation of the subcortical regions of interest extracted with FreeSurfer. Not shown: amygdala. Abbreviations: Ca, caudate; Hi, hippocampus; Lv, lateral ventricles; Pa, pallidum; Pu, putamen; Th, thalamus.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834463&req=5

f0005: Subcortical regions of interest. Three-dimensional representation of the subcortical regions of interest extracted with FreeSurfer. Not shown: amygdala. Abbreviations: Ca, caudate; Hi, hippocampus; Lv, lateral ventricles; Pa, pallidum; Pu, putamen; Th, thalamus.
Mentions: The following regions of interest (ROI) were extracted for each hemisphere (Fig. 1): lateral ventricles, caudate, putamen, pallidum, hippocampus, thalamus, amygdala. We decided to compare the volumes of these subcortical brain regions separately for each hemisphere since some findings in unaffected relatives of BD patients or first-episode MDD patients point towards specific lateralisation effects (Frodl et al., 2002, Nery et al., 2013). In addition, intra-cranial volume of the whole brain was extracted to serve as a covariate.

Bottom Line: Additionally, no significant differences emerged between groups over time.Our results indicate that volumetric subcortical brain abnormalities of these regions using the current method appear not to form familial trait markers for vulnerability to mood disorders in close relatives of bipolar disorder patients over the two-year time period studied.Moreover, they do not appear to reduce in response to illness onset at least for the time period studied.

View Article: PubMed Central - PubMed

Affiliation: Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, United Kingdom; Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: martina.papmeyer@puk.unibe.ch.

No MeSH data available.


Related in: MedlinePlus