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Is it me? Verbal self-monitoring neural network and clinical insight in schizophrenia.

Sapara A, Ffytche DH, Cooke MA, Williams SC, Kumari V - Psychiatry Res (2015)

Bottom Line: Healthy participants showed higher performance accuracy and greater thalamic activity than both preserved and poor insight patient groups.Preserved insight patients showed higher activity in the putamen extending into the caudate, insula and inferior frontal gyrus, compared to poor insight patients, and in the anterior cingulate and medial frontal gyrus, compared to healthy participants.Poor insight patients did not show greater activity in any brain area compared to preserved insight patients or healthy participants.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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Related in: MedlinePlus

Axial sections of a standard MNI brain with areas of greater activity in the preserved insight group, compared to the healthy participant and poor insight groups superimposed (height threshold p<0.05, cluster-corrected p<0.05). The MNI Z co-ordinate is given below each image. Right of image=left hemisphere.
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f0005: Axial sections of a standard MNI brain with areas of greater activity in the preserved insight group, compared to the healthy participant and poor insight groups superimposed (height threshold p<0.05, cluster-corrected p<0.05). The MNI Z co-ordinate is given below each image. Right of image=left hemisphere.

Mentions: Healthy participants, relative to preserved insight patients, again showed greater activity in the thalami (bilaterally) and the right posterior cingulate (Self condition). Preserved insight patients showed greater activity in the ACC and medial-middle frontal gyrus (Self condition) (Fig. 1).


Is it me? Verbal self-monitoring neural network and clinical insight in schizophrenia.

Sapara A, Ffytche DH, Cooke MA, Williams SC, Kumari V - Psychiatry Res (2015)

Axial sections of a standard MNI brain with areas of greater activity in the preserved insight group, compared to the healthy participant and poor insight groups superimposed (height threshold p<0.05, cluster-corrected p<0.05). The MNI Z co-ordinate is given below each image. Right of image=left hemisphere.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834462&req=5

f0005: Axial sections of a standard MNI brain with areas of greater activity in the preserved insight group, compared to the healthy participant and poor insight groups superimposed (height threshold p<0.05, cluster-corrected p<0.05). The MNI Z co-ordinate is given below each image. Right of image=left hemisphere.
Mentions: Healthy participants, relative to preserved insight patients, again showed greater activity in the thalami (bilaterally) and the right posterior cingulate (Self condition). Preserved insight patients showed greater activity in the ACC and medial-middle frontal gyrus (Self condition) (Fig. 1).

Bottom Line: Healthy participants showed higher performance accuracy and greater thalamic activity than both preserved and poor insight patient groups.Preserved insight patients showed higher activity in the putamen extending into the caudate, insula and inferior frontal gyrus, compared to poor insight patients, and in the anterior cingulate and medial frontal gyrus, compared to healthy participants.Poor insight patients did not show greater activity in any brain area compared to preserved insight patients or healthy participants.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Show MeSH
Related in: MedlinePlus