Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.
Bottom Line: As the development of cortical surface is closely linked to the establishment of thalam-ocortical connections, any abnormalities in the structure of the thalamus are likely to relate to altered cortical surface area.Furthermore, children with ADHD with smaller thalamic volumes were found to have greater reductions in surface area, a pattern not evident in the control children.Our results are further evidence of reduced lateral prefrontal cortical area in ADHD.
Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.Show MeSH
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Mentions: Within the patient group, thalamic volume was a positive predictor of surface area in a number of other clusters, including right precuneus, right dorsolateral frontal, and right postcentral sulcus on the right hemisphere, and left dorsolateral frontal and left anterior cingulate region on the left hemisphere (Fig. 3; Table 2). Interestingly, controls showed no such covariance with thalamic volume. These effects persisted even when IQ was not used as a covariate.
Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.