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Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.

Batty MJ, Palaniyappan L, Scerif G, Groom MJ, Liddle EB, Liddle PF, Hollis C - Psychiatry Res (2015)

Bottom Line: As the development of cortical surface is closely linked to the establishment of thalam-ocortical connections, any abnormalities in the structure of the thalamus are likely to relate to altered cortical surface area.Furthermore, children with ADHD with smaller thalamic volumes were found to have greater reductions in surface area, a pattern not evident in the control children.Our results are further evidence of reduced lateral prefrontal cortical area in ADHD.

View Article: PubMed Central - PubMed

Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.

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Related in: MedlinePlus

Differential effect of thalamic volume on surface area in children with ADHD and healthy controls. Panel A: A single cluster in the right prefrontal cortex showed a significant interaction between thalamic volume and diagnosis of ADHD. In this cluster, patients showed a significant positive relationship with thalamic volume, while controls showed a trend towards a negative relationship. Panel B: Scatter plots displaying the relationship between thalamic volume and surface area of right and left prefrontal clusters that showed significant surface area reduction in children with ADHD (see Fig. 1). Standardised residuals of thalamic volume and surface area measures adjusting for age and total brain volume were used for all scatter plots.
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f0010: Differential effect of thalamic volume on surface area in children with ADHD and healthy controls. Panel A: A single cluster in the right prefrontal cortex showed a significant interaction between thalamic volume and diagnosis of ADHD. In this cluster, patients showed a significant positive relationship with thalamic volume, while controls showed a trend towards a negative relationship. Panel B: Scatter plots displaying the relationship between thalamic volume and surface area of right and left prefrontal clusters that showed significant surface area reduction in children with ADHD (see Fig. 1). Standardised residuals of thalamic volume and surface area measures adjusting for age and total brain volume were used for all scatter plots.

Mentions: In the whole brain analysis seeking the brain regions showing differential covariance with thalamic volume in the two groups, a significant interaction between thalamic volume and the diagnosis of ADHD was seen in a cluster that included right inferior and mid-lateral prefrontal cortex (BA 10, BA 45, BA 46, BA 47; Fig. 2). In this cluster, children with ADHD with a smaller thalamic volume showed a greater reduction in the surface area (r=0.60, df=23, p=0.001), while controls showed a trend towards a negative association with thalamic volume (r=−0.34, df=22, p=0.1). No other cortical region showed an ADHD-specific relationship between thalamic volume and surface area.


Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.

Batty MJ, Palaniyappan L, Scerif G, Groom MJ, Liddle EB, Liddle PF, Hollis C - Psychiatry Res (2015)

Differential effect of thalamic volume on surface area in children with ADHD and healthy controls. Panel A: A single cluster in the right prefrontal cortex showed a significant interaction between thalamic volume and diagnosis of ADHD. In this cluster, patients showed a significant positive relationship with thalamic volume, while controls showed a trend towards a negative relationship. Panel B: Scatter plots displaying the relationship between thalamic volume and surface area of right and left prefrontal clusters that showed significant surface area reduction in children with ADHD (see Fig. 1). Standardised residuals of thalamic volume and surface area measures adjusting for age and total brain volume were used for all scatter plots.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834461&req=5

f0010: Differential effect of thalamic volume on surface area in children with ADHD and healthy controls. Panel A: A single cluster in the right prefrontal cortex showed a significant interaction between thalamic volume and diagnosis of ADHD. In this cluster, patients showed a significant positive relationship with thalamic volume, while controls showed a trend towards a negative relationship. Panel B: Scatter plots displaying the relationship between thalamic volume and surface area of right and left prefrontal clusters that showed significant surface area reduction in children with ADHD (see Fig. 1). Standardised residuals of thalamic volume and surface area measures adjusting for age and total brain volume were used for all scatter plots.
Mentions: In the whole brain analysis seeking the brain regions showing differential covariance with thalamic volume in the two groups, a significant interaction between thalamic volume and the diagnosis of ADHD was seen in a cluster that included right inferior and mid-lateral prefrontal cortex (BA 10, BA 45, BA 46, BA 47; Fig. 2). In this cluster, children with ADHD with a smaller thalamic volume showed a greater reduction in the surface area (r=0.60, df=23, p=0.001), while controls showed a trend towards a negative association with thalamic volume (r=−0.34, df=22, p=0.1). No other cortical region showed an ADHD-specific relationship between thalamic volume and surface area.

Bottom Line: As the development of cortical surface is closely linked to the establishment of thalam-ocortical connections, any abnormalities in the structure of the thalamus are likely to relate to altered cortical surface area.Furthermore, children with ADHD with smaller thalamic volumes were found to have greater reductions in surface area, a pattern not evident in the control children.Our results are further evidence of reduced lateral prefrontal cortical area in ADHD.

View Article: PubMed Central - PubMed

Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.

Show MeSH
Related in: MedlinePlus