Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.
Bottom Line: As the development of cortical surface is closely linked to the establishment of thalam-ocortical connections, any abnormalities in the structure of the thalamus are likely to relate to altered cortical surface area.Furthermore, children with ADHD with smaller thalamic volumes were found to have greater reductions in surface area, a pattern not evident in the control children.Our results are further evidence of reduced lateral prefrontal cortical area in ADHD.
Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.Show MeSH
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Mentions: In the whole brain analysis seeking the brain regions showing differential covariance with thalamic volume in the two groups, a significant interaction between thalamic volume and the diagnosis of ADHD was seen in a cluster that included right inferior and mid-lateral prefrontal cortex (BA 10, BA 45, BA 46, BA 47; Fig. 2). In this cluster, children with ADHD with a smaller thalamic volume showed a greater reduction in the surface area (r=0.60, df=23, p=0.001), while controls showed a trend towards a negative association with thalamic volume (r=−0.34, df=22, p=0.1). No other cortical region showed an ADHD-specific relationship between thalamic volume and surface area.
Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.