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Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.

Batty MJ, Palaniyappan L, Scerif G, Groom MJ, Liddle EB, Liddle PF, Hollis C - Psychiatry Res (2015)

Bottom Line: As the development of cortical surface is closely linked to the establishment of thalam-ocortical connections, any abnormalities in the structure of the thalamus are likely to relate to altered cortical surface area.Furthermore, children with ADHD with smaller thalamic volumes were found to have greater reductions in surface area, a pattern not evident in the control children.Our results are further evidence of reduced lateral prefrontal cortical area in ADHD.

View Article: PubMed Central - PubMed

Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.

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Related in: MedlinePlus

Brain regions showing significant surface area reduction in children with ADHD compared with healthy controls. No brain regions showed an increase in surface area. In this and subsequent figures, results are corrected for multiple testing using Monte Carlo permutations with an inclusion threshold of p=0.05. The left and right hemispheres are displayed on the left and right sides of the figure, respectively.
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f0005: Brain regions showing significant surface area reduction in children with ADHD compared with healthy controls. No brain regions showed an increase in surface area. In this and subsequent figures, results are corrected for multiple testing using Monte Carlo permutations with an inclusion threshold of p=0.05. The left and right hemispheres are displayed on the left and right sides of the figure, respectively.

Mentions: Vertexwise analysis of the effect of diagnosis on surface area revealed a significant reduction in dorsolateral prefrontal cortical area in children with ADHD in both right and left hemispheres. On both hemispheres, the clusters showing areal contraction overlapped with Brodmann areas (BA) 9, 10 and 46 (Fig. 1, Table 2). Those diagnostic effects remained even when the two female subjects were removed from the analysis, and when IQ was not used as a covariate. Age and brain volume did not have any significant effects on the observed differences.


Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.

Batty MJ, Palaniyappan L, Scerif G, Groom MJ, Liddle EB, Liddle PF, Hollis C - Psychiatry Res (2015)

Brain regions showing significant surface area reduction in children with ADHD compared with healthy controls. No brain regions showed an increase in surface area. In this and subsequent figures, results are corrected for multiple testing using Monte Carlo permutations with an inclusion threshold of p=0.05. The left and right hemispheres are displayed on the left and right sides of the figure, respectively.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834461&req=5

f0005: Brain regions showing significant surface area reduction in children with ADHD compared with healthy controls. No brain regions showed an increase in surface area. In this and subsequent figures, results are corrected for multiple testing using Monte Carlo permutations with an inclusion threshold of p=0.05. The left and right hemispheres are displayed on the left and right sides of the figure, respectively.
Mentions: Vertexwise analysis of the effect of diagnosis on surface area revealed a significant reduction in dorsolateral prefrontal cortical area in children with ADHD in both right and left hemispheres. On both hemispheres, the clusters showing areal contraction overlapped with Brodmann areas (BA) 9, 10 and 46 (Fig. 1, Table 2). Those diagnostic effects remained even when the two female subjects were removed from the analysis, and when IQ was not used as a covariate. Age and brain volume did not have any significant effects on the observed differences.

Bottom Line: As the development of cortical surface is closely linked to the establishment of thalam-ocortical connections, any abnormalities in the structure of the thalamus are likely to relate to altered cortical surface area.Furthermore, children with ADHD with smaller thalamic volumes were found to have greater reductions in surface area, a pattern not evident in the control children.Our results are further evidence of reduced lateral prefrontal cortical area in ADHD.

View Article: PubMed Central - PubMed

Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.

Show MeSH
Related in: MedlinePlus