Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder.
Bottom Line: As the development of cortical surface is closely linked to the establishment of thalam-ocortical connections, any abnormalities in the structure of the thalamus are likely to relate to altered cortical surface area.Furthermore, children with ADHD with smaller thalamic volumes were found to have greater reductions in surface area, a pattern not evident in the control children.Our results are further evidence of reduced lateral prefrontal cortical area in ADHD.
Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.Show MeSH
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Mentions: Vertexwise analysis of the effect of diagnosis on surface area revealed a significant reduction in dorsolateral prefrontal cortical area in children with ADHD in both right and left hemispheres. On both hemispheres, the clusters showing areal contraction overlapped with Brodmann areas (BA) 9, 10 and 46 (Fig. 1, Table 2). Those diagnostic effects remained even when the two female subjects were removed from the analysis, and when IQ was not used as a covariate. Age and brain volume did not have any significant effects on the observed differences.
Affiliation: Institute of Mental Health, University of Nottingham, Nottingham, UK; University Hospitals of Leicester NHS Trust, Leicester, UK.