Orbitofrontal cortex, emotional decision-making and response to cognitive behavioural therapy for psychosis.
Bottom Line: In the CBTp+SC group, greater OFC GMV correlated with positive symptom improvement, specifically hallucinations and persecution.Greater left OFC GMV was associated with lower IGT attention to reward.The findings suggest that greater OFC volume and rightward asymmetry, which maintain the OFC׳s function in emotional decision-making and cognitive flexibility, are beneficial for CBTp responsiveness.
Affiliation: Division of Psychology, School of Social Sciences, Nottingham Trent University, Nottingham, UK. Electronic address: Preethi.firstname.lastname@example.org.Show MeSH
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Mentions: The OFC was measured using established criteria (Buchanan et al., 1998, Buchanan et al., 2004, Sapara et al., 2007; Kumari et al., 2009a; Ettinger et al., 2012). The OFC was defined superiorly by the horizontal ramus of the Sylvian fissure, medially by the superior rostral sulcus as it merges into the frontomarginal sulcus anteriorly, and posteriorly by the anterior olfactory sulcus (seen only in the midsagittal section) (Fig. 1).
Affiliation: Division of Psychology, School of Social Sciences, Nottingham Trent University, Nottingham, UK. Electronic address: Preethi.email@example.com.