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The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25.

Khuu C, Utheim TP, Sehic A - Scientifica (Cairo) (2016)

Bottom Line: As miR-106a-363 and miR-106b-25 contain miRNAs that are very similar, and in some cases identical, to those encoded by miR-17-92, it is feasible that they regulate a similar set of genes and have overlapping functions.Further understanding of these three clusters and their functions will increase our knowledge about cancer progression.The present review discusses the characteristics and functions of these three miRNA clusters.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Biology, Faculty of Dentistry, University of Oslo, 0372 Oslo, Norway.

ABSTRACT
MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation of normal developmental programs and tumor genesis. An increasing body of evidence suggests that altered expression of miRNAs is entailed in the pathogenesis of human cancers. Studies in mouse and human cells have identified the miR-17-92 cluster as a potential oncogene. The miR-17-92 cluster is often amplified or overexpressed in human cancers and has recently emerged as the prototypical oncogenic polycistron miRNA. The functional analysis of miR-17-92 is intricate by the existence of two paralogues: miR-106a-363 and miR-106b-25. During early evolution of vertebrates, it is likely that the three clusters commenced via a series of duplication and deletion occurrences. As miR-106a-363 and miR-106b-25 contain miRNAs that are very similar, and in some cases identical, to those encoded by miR-17-92, it is feasible that they regulate a similar set of genes and have overlapping functions. Further understanding of these three clusters and their functions will increase our knowledge about cancer progression. The present review discusses the characteristics and functions of these three miRNA clusters.

No MeSH data available.


Related in: MedlinePlus

Schematic illustration of possible regulatory interactions between miRNAs encoded by the three paralogue clusters and with the E2F transcription factor family. Stimulatory effects are shown using green lines; inhibitory effects are shown using red lines.
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fig2: Schematic illustration of possible regulatory interactions between miRNAs encoded by the three paralogue clusters and with the E2F transcription factor family. Stimulatory effects are shown using green lines; inhibitory effects are shown using red lines.

Mentions: Among the three polycistronic, paralogue clusters (miR-17-92, miR-106a-363, and miR-106b-25), the miR-17-92 cluster is so far the most studied. The miR-17-92 cluster is located on chromosome 13 in open reading frame 25 (C13orf25) in the human genome and on chromosome 14 in the mouse genome [32, 34, 38]. The primary transcript encodes six mature miRNAs: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a-1 (Figure 2, Table 1). These are encoded within 800-base-pair region in the human genome. The six miRNAs can be grouped into four miRNA families based on their seed-sequence: the miR-17 family (miR-17 and miR-20a), the miR-18 family (miR-18a), the miR-19 family (miR-19a and miR-19b-1), and miR-92 family (miR-92a-1) [31, 34, 39].


The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25.

Khuu C, Utheim TP, Sehic A - Scientifica (Cairo) (2016)

Schematic illustration of possible regulatory interactions between miRNAs encoded by the three paralogue clusters and with the E2F transcription factor family. Stimulatory effects are shown using green lines; inhibitory effects are shown using red lines.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834410&req=5

fig2: Schematic illustration of possible regulatory interactions between miRNAs encoded by the three paralogue clusters and with the E2F transcription factor family. Stimulatory effects are shown using green lines; inhibitory effects are shown using red lines.
Mentions: Among the three polycistronic, paralogue clusters (miR-17-92, miR-106a-363, and miR-106b-25), the miR-17-92 cluster is so far the most studied. The miR-17-92 cluster is located on chromosome 13 in open reading frame 25 (C13orf25) in the human genome and on chromosome 14 in the mouse genome [32, 34, 38]. The primary transcript encodes six mature miRNAs: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a-1 (Figure 2, Table 1). These are encoded within 800-base-pair region in the human genome. The six miRNAs can be grouped into four miRNA families based on their seed-sequence: the miR-17 family (miR-17 and miR-20a), the miR-18 family (miR-18a), the miR-19 family (miR-19a and miR-19b-1), and miR-92 family (miR-92a-1) [31, 34, 39].

Bottom Line: As miR-106a-363 and miR-106b-25 contain miRNAs that are very similar, and in some cases identical, to those encoded by miR-17-92, it is feasible that they regulate a similar set of genes and have overlapping functions.Further understanding of these three clusters and their functions will increase our knowledge about cancer progression.The present review discusses the characteristics and functions of these three miRNA clusters.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Biology, Faculty of Dentistry, University of Oslo, 0372 Oslo, Norway.

ABSTRACT
MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation of normal developmental programs and tumor genesis. An increasing body of evidence suggests that altered expression of miRNAs is entailed in the pathogenesis of human cancers. Studies in mouse and human cells have identified the miR-17-92 cluster as a potential oncogene. The miR-17-92 cluster is often amplified or overexpressed in human cancers and has recently emerged as the prototypical oncogenic polycistron miRNA. The functional analysis of miR-17-92 is intricate by the existence of two paralogues: miR-106a-363 and miR-106b-25. During early evolution of vertebrates, it is likely that the three clusters commenced via a series of duplication and deletion occurrences. As miR-106a-363 and miR-106b-25 contain miRNAs that are very similar, and in some cases identical, to those encoded by miR-17-92, it is feasible that they regulate a similar set of genes and have overlapping functions. Further understanding of these three clusters and their functions will increase our knowledge about cancer progression. The present review discusses the characteristics and functions of these three miRNA clusters.

No MeSH data available.


Related in: MedlinePlus