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Hemispheric Coherence in ASD with and without Comorbid ADHD and Anxiety.

Saunders A, Kirk IJ, Waldie KE - Biomed Res Int (2016)

Bottom Line: Analyses revealed increased coherence across central electrodes over the primary motor cortex and decreased coherence in the frontal lobe networks in those with ASD compared to neurotypical controls.The patterns of coherence in the ASD pure group were different when comorbid conditions were included in the analyses, suggesting that aberrant coherence in the frontal and central areas of the brain is specifically associated with ASD.Our findings support the idea that comorbid conditions are additive, rather than being symptoms of the same disorder.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, The University of Auckland, Auckland 1010, New Zealand.

ABSTRACT
There is a growing body of evidence suggesting that altered brain connectivity may be a defining feature of disorders such as autism spectrum disorder (ASD), anxiety, and ADHD. This study investigated whether resting state functional connectivity, measured by 128-channel EEG oscillation coherence, differs between developmental disorders. Analyses were conducted separately on groups with and without comorbid conditions. Analyses revealed increased coherence across central electrodes over the primary motor cortex and decreased coherence in the frontal lobe networks in those with ASD compared to neurotypical controls. There was increased coherence in occipital lobe networks in the ADHD group compared to other groups. Symptoms of generalised anxiety were positively correlated with both frontal-occipital intrahemispheric (alpha only) coherence and occipital interhemispheric coherence (alpha, approaching theta band). The patterns of coherence in the ASD pure group were different when comorbid conditions were included in the analyses, suggesting that aberrant coherence in the frontal and central areas of the brain is specifically associated with ASD. Our findings support the idea that comorbid conditions are additive, rather than being symptoms of the same disorder.

No MeSH data available.


Related in: MedlinePlus

Interaction between gender and experimental group for the frontal-frontal interhemispheric coherence values in the alpha eyes closed condition. Significant effects at the .05 level are marked with an asterisk.
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fig1: Interaction between gender and experimental group for the frontal-frontal interhemispheric coherence values in the alpha eyes closed condition. Significant effects at the .05 level are marked with an asterisk.

Mentions: A 2 (gender) × 4 (ADHD, anxiety, ASD, and control) multivariate ANOVA was conducted on the eyes closed alpha band coherence values. There were no significant effects for any coherence values for either gender or experimental group. There was an interaction between gender and experimental group for the frontal-frontal interhemispheric coherence scores that was approaching significance, F(3,39) = 2.80, p = .053. For the ADHD group only, males (M = 1.08, SE = .10) had significantly higher coherence values than females (M = .72, SE = .13, p = .035), as shown in Figure 1.


Hemispheric Coherence in ASD with and without Comorbid ADHD and Anxiety.

Saunders A, Kirk IJ, Waldie KE - Biomed Res Int (2016)

Interaction between gender and experimental group for the frontal-frontal interhemispheric coherence values in the alpha eyes closed condition. Significant effects at the .05 level are marked with an asterisk.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834397&req=5

fig1: Interaction between gender and experimental group for the frontal-frontal interhemispheric coherence values in the alpha eyes closed condition. Significant effects at the .05 level are marked with an asterisk.
Mentions: A 2 (gender) × 4 (ADHD, anxiety, ASD, and control) multivariate ANOVA was conducted on the eyes closed alpha band coherence values. There were no significant effects for any coherence values for either gender or experimental group. There was an interaction between gender and experimental group for the frontal-frontal interhemispheric coherence scores that was approaching significance, F(3,39) = 2.80, p = .053. For the ADHD group only, males (M = 1.08, SE = .10) had significantly higher coherence values than females (M = .72, SE = .13, p = .035), as shown in Figure 1.

Bottom Line: Analyses revealed increased coherence across central electrodes over the primary motor cortex and decreased coherence in the frontal lobe networks in those with ASD compared to neurotypical controls.The patterns of coherence in the ASD pure group were different when comorbid conditions were included in the analyses, suggesting that aberrant coherence in the frontal and central areas of the brain is specifically associated with ASD.Our findings support the idea that comorbid conditions are additive, rather than being symptoms of the same disorder.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, The University of Auckland, Auckland 1010, New Zealand.

ABSTRACT
There is a growing body of evidence suggesting that altered brain connectivity may be a defining feature of disorders such as autism spectrum disorder (ASD), anxiety, and ADHD. This study investigated whether resting state functional connectivity, measured by 128-channel EEG oscillation coherence, differs between developmental disorders. Analyses were conducted separately on groups with and without comorbid conditions. Analyses revealed increased coherence across central electrodes over the primary motor cortex and decreased coherence in the frontal lobe networks in those with ASD compared to neurotypical controls. There was increased coherence in occipital lobe networks in the ADHD group compared to other groups. Symptoms of generalised anxiety were positively correlated with both frontal-occipital intrahemispheric (alpha only) coherence and occipital interhemispheric coherence (alpha, approaching theta band). The patterns of coherence in the ASD pure group were different when comorbid conditions were included in the analyses, suggesting that aberrant coherence in the frontal and central areas of the brain is specifically associated with ASD. Our findings support the idea that comorbid conditions are additive, rather than being symptoms of the same disorder.

No MeSH data available.


Related in: MedlinePlus