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The Clinical Effect of Acupuncture in the Treatment of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Lv ZT, Jiang WX, Huang JM, Zhang JM, Chen AM - Evid Based Complement Alternat Med (2016)

Bottom Line: Electroacupuncture (EA) was better in improving the AHI and apnea index when compared with control treatment, but no statistically significant differences in hypopnea index and mean SaO2 were found.Conclusion.Compared to control groups, both MA and EA were more effective in improving AHI and mean SaO2.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

ABSTRACT
Purpose. This study aims to determine the clinical efficacy of acupuncture therapy in the treatment of obstructive sleep apnea. Methods. A systematic literature search was conducted in five databases including PubMed, EMBASE, CENTRAL, Wanfang, and CNKI to identify randomized controlled trials (RCTs) on the effect of acupuncture therapy for obstructive sleep apnea. Meta-analysis was conducted using the RevMan version 5.3 software. Results. Six RCTs involving 362 subjects were included in our study. Compared with control groups, manual acupuncture (MA) was more effective in the improvement of apnea/hypopnea index (AHI), apnea index, hypopnea index, and mean SaO2. Electroacupuncture (EA) was better in improving the AHI and apnea index when compared with control treatment, but no statistically significant differences in hypopnea index and mean SaO2 were found. In the comparison of MA and nasal continuous positive airway pressure, the results favored MA in the improvement of AHI; there was no statistical difference in the improvement in mean SaO2. No adverse events associated with acupuncture therapy were documented. Conclusion. Compared to control groups, both MA and EA were more effective in improving AHI and mean SaO2. In addition, MA could further improve apnea index and hypopnea index compared to control.

No MeSH data available.


Related in: MedlinePlus

Forest plot of acupuncture therapy versus control group: hypopnea index; the authors' judgment about each risk of bias item for each included study.
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fig4: Forest plot of acupuncture therapy versus control group: hypopnea index; the authors' judgment about each risk of bias item for each included study.

Mentions: To assess the risk of bias among included studies, Cochrane Collaboration's tool was employed. All of the six studies reported suggested randomization; however, two studies [25, 26] failed to provide the method of random sequence generation. Only two studies [22, 24] reported the procedure of allocation concealment, and the blinding of participants and personnel was carried out appropriately in these two trials; the investigators conducted RCT according to a strict study protocol approved by the ethical committee of the Universidade Federal de Sao Paulo. None of the four remaining studies [23, 25–27] provided detailed information about the allocation concealment and blinding of participants and personnel. The blinding of outcome measure was judged to low risk of bias because all the outcomes were measured depending on the records of PSG; the accuracy and objectivity were unlikely to be influenced by lack of blinding. Regarding the selective reporting, all the trials were judged to low risk of bias, since we only included studies that reported AHI, apnea index, hypopnea index, and mean SaO2 as outcome. No study reported adverse events associated with acupuncture sessions. Good compliance seemed to be achieved in all studies; each study reported characterized similarity of baseline. Finally, two studies [22, 24] were judged to low risk of bias; the four remaining studies [23, 25–27] were judged to high risk of bias. The risk of bias assessment of each study was listed in corresponding forest plot (Figures 2, 3, 4, 5, 6, and 7).


The Clinical Effect of Acupuncture in the Treatment of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Lv ZT, Jiang WX, Huang JM, Zhang JM, Chen AM - Evid Based Complement Alternat Med (2016)

Forest plot of acupuncture therapy versus control group: hypopnea index; the authors' judgment about each risk of bias item for each included study.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834396&req=5

fig4: Forest plot of acupuncture therapy versus control group: hypopnea index; the authors' judgment about each risk of bias item for each included study.
Mentions: To assess the risk of bias among included studies, Cochrane Collaboration's tool was employed. All of the six studies reported suggested randomization; however, two studies [25, 26] failed to provide the method of random sequence generation. Only two studies [22, 24] reported the procedure of allocation concealment, and the blinding of participants and personnel was carried out appropriately in these two trials; the investigators conducted RCT according to a strict study protocol approved by the ethical committee of the Universidade Federal de Sao Paulo. None of the four remaining studies [23, 25–27] provided detailed information about the allocation concealment and blinding of participants and personnel. The blinding of outcome measure was judged to low risk of bias because all the outcomes were measured depending on the records of PSG; the accuracy and objectivity were unlikely to be influenced by lack of blinding. Regarding the selective reporting, all the trials were judged to low risk of bias, since we only included studies that reported AHI, apnea index, hypopnea index, and mean SaO2 as outcome. No study reported adverse events associated with acupuncture sessions. Good compliance seemed to be achieved in all studies; each study reported characterized similarity of baseline. Finally, two studies [22, 24] were judged to low risk of bias; the four remaining studies [23, 25–27] were judged to high risk of bias. The risk of bias assessment of each study was listed in corresponding forest plot (Figures 2, 3, 4, 5, 6, and 7).

Bottom Line: Electroacupuncture (EA) was better in improving the AHI and apnea index when compared with control treatment, but no statistically significant differences in hypopnea index and mean SaO2 were found.Conclusion.Compared to control groups, both MA and EA were more effective in improving AHI and mean SaO2.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

ABSTRACT
Purpose. This study aims to determine the clinical efficacy of acupuncture therapy in the treatment of obstructive sleep apnea. Methods. A systematic literature search was conducted in five databases including PubMed, EMBASE, CENTRAL, Wanfang, and CNKI to identify randomized controlled trials (RCTs) on the effect of acupuncture therapy for obstructive sleep apnea. Meta-analysis was conducted using the RevMan version 5.3 software. Results. Six RCTs involving 362 subjects were included in our study. Compared with control groups, manual acupuncture (MA) was more effective in the improvement of apnea/hypopnea index (AHI), apnea index, hypopnea index, and mean SaO2. Electroacupuncture (EA) was better in improving the AHI and apnea index when compared with control treatment, but no statistically significant differences in hypopnea index and mean SaO2 were found. In the comparison of MA and nasal continuous positive airway pressure, the results favored MA in the improvement of AHI; there was no statistical difference in the improvement in mean SaO2. No adverse events associated with acupuncture therapy were documented. Conclusion. Compared to control groups, both MA and EA were more effective in improving AHI and mean SaO2. In addition, MA could further improve apnea index and hypopnea index compared to control.

No MeSH data available.


Related in: MedlinePlus