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Metabolic and histopathological effects of sleeve gastrectomy and gastric plication: an experimental rodent model.

Gulcicek OB, Ozdogan K, Solmaz A, Yigitbas H, Altınay S, Gunes A, Celik DS, Yavuz E, Celik A, Celebi F - Food Nutr Res (2016)

Bottom Line: Gastrin levels of the SG group increased significantly compared with those of the control group.Foveolar hyperplasia (FH), cystic glandular dilatation, and fibrosis were significantly higher in the GP and SG groups compared with the control group.Histopathological findings revealed that FH, fibrosis, and the cystic glandular dilatation development rates were similar.

View Article: PubMed Central - PubMed

Affiliation: General Surgery Clinic, Bagcilar Training and Research Hospital, Istanbul, Turkey; drosmanbilgin@hotmail.com.

ABSTRACT

Introduction: Obesity has recently become a major health problem, and researchers have been directed to work toward the development of surgical techniques, with new mediators playing an important role in nutrition. Gastric plication (GP) and sleeve gastrectomy (SG) have become popular recently. These are widely used techniques in bariatric surgery.

Objectives: In this study, we aimed to compare the efficiency of SG and GP techniques on rats.

Methods: Wistar-Hannover rats (n=18) were divided into three equal groups, namely SG, GP, and control. Blood samples were taken before the operation and on the 30th day after the operation. The weights of all rats were recorded both on first day and the 30th day after the operation. Serum gastrin, ghrelin, and leptin levels were also measured on the same days. For histopathological examination, gastrectomy was performed after the animals were sacrificed.

Results: Average weight loss was 10% for the SG group and 6.5% for the GP group. One month after the operations, the decrease in the ghrelin and leptin levels of GP and SG groups was significant compared with the levels of the control group. Gastrin levels of the SG group increased significantly compared with those of the control group. Histopathological examination revealed that there was significant decrease in the ghrelin and leptin levels of the GP and SG groups compared with those of the control group. Foveolar hyperplasia (FH), cystic glandular dilatation, and fibrosis were significantly higher in the GP and SG groups compared with the control group.

Conclusion: Although GP is not as effective as SG in terms of weight loss, it provides the same effectiveness in decreasing ghrelin and leptin levels. Histopathological findings revealed that FH, fibrosis, and the cystic glandular dilatation development rates were similar.

No MeSH data available.


Related in: MedlinePlus

There is prominent foveolar hyperplasia (a, H&E, ×100) and also marked gastric cystic dilatation in the SG group (b, H&E, ×100) on histopathological examination. We see mild fibrosis on the serosal surface of the GP group (c, Masson's trichrome stain, ×40). Contrarily, there is prominent fibrosis on the serosal surface of the GP group, which manifest as blue colored areas on histochemical examination (d, Masson's trichrome stain, ×40) (GP: gastric plication, SG: sleeve gastrectomy).
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Figure 0002: There is prominent foveolar hyperplasia (a, H&E, ×100) and also marked gastric cystic dilatation in the SG group (b, H&E, ×100) on histopathological examination. We see mild fibrosis on the serosal surface of the GP group (c, Masson's trichrome stain, ×40). Contrarily, there is prominent fibrosis on the serosal surface of the GP group, which manifest as blue colored areas on histochemical examination (d, Masson's trichrome stain, ×40) (GP: gastric plication, SG: sleeve gastrectomy).

Mentions: FH, cystic glandular dysplasia (CGD), and the grade of fibrosis were significantly higher in both groups than in the control group (p=0.008, p=0.001, p=0.001). Although this increase was higher in the SG group, there was no significant difference between the groups (p>0.05) (Table 3 and Fig. 2).


Metabolic and histopathological effects of sleeve gastrectomy and gastric plication: an experimental rodent model.

Gulcicek OB, Ozdogan K, Solmaz A, Yigitbas H, Altınay S, Gunes A, Celik DS, Yavuz E, Celik A, Celebi F - Food Nutr Res (2016)

There is prominent foveolar hyperplasia (a, H&E, ×100) and also marked gastric cystic dilatation in the SG group (b, H&E, ×100) on histopathological examination. We see mild fibrosis on the serosal surface of the GP group (c, Masson's trichrome stain, ×40). Contrarily, there is prominent fibrosis on the serosal surface of the GP group, which manifest as blue colored areas on histochemical examination (d, Masson's trichrome stain, ×40) (GP: gastric plication, SG: sleeve gastrectomy).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834363&req=5

Figure 0002: There is prominent foveolar hyperplasia (a, H&E, ×100) and also marked gastric cystic dilatation in the SG group (b, H&E, ×100) on histopathological examination. We see mild fibrosis on the serosal surface of the GP group (c, Masson's trichrome stain, ×40). Contrarily, there is prominent fibrosis on the serosal surface of the GP group, which manifest as blue colored areas on histochemical examination (d, Masson's trichrome stain, ×40) (GP: gastric plication, SG: sleeve gastrectomy).
Mentions: FH, cystic glandular dysplasia (CGD), and the grade of fibrosis were significantly higher in both groups than in the control group (p=0.008, p=0.001, p=0.001). Although this increase was higher in the SG group, there was no significant difference between the groups (p>0.05) (Table 3 and Fig. 2).

Bottom Line: Gastrin levels of the SG group increased significantly compared with those of the control group.Foveolar hyperplasia (FH), cystic glandular dilatation, and fibrosis were significantly higher in the GP and SG groups compared with the control group.Histopathological findings revealed that FH, fibrosis, and the cystic glandular dilatation development rates were similar.

View Article: PubMed Central - PubMed

Affiliation: General Surgery Clinic, Bagcilar Training and Research Hospital, Istanbul, Turkey; drosmanbilgin@hotmail.com.

ABSTRACT

Introduction: Obesity has recently become a major health problem, and researchers have been directed to work toward the development of surgical techniques, with new mediators playing an important role in nutrition. Gastric plication (GP) and sleeve gastrectomy (SG) have become popular recently. These are widely used techniques in bariatric surgery.

Objectives: In this study, we aimed to compare the efficiency of SG and GP techniques on rats.

Methods: Wistar-Hannover rats (n=18) were divided into three equal groups, namely SG, GP, and control. Blood samples were taken before the operation and on the 30th day after the operation. The weights of all rats were recorded both on first day and the 30th day after the operation. Serum gastrin, ghrelin, and leptin levels were also measured on the same days. For histopathological examination, gastrectomy was performed after the animals were sacrificed.

Results: Average weight loss was 10% for the SG group and 6.5% for the GP group. One month after the operations, the decrease in the ghrelin and leptin levels of GP and SG groups was significant compared with the levels of the control group. Gastrin levels of the SG group increased significantly compared with those of the control group. Histopathological examination revealed that there was significant decrease in the ghrelin and leptin levels of the GP and SG groups compared with those of the control group. Foveolar hyperplasia (FH), cystic glandular dilatation, and fibrosis were significantly higher in the GP and SG groups compared with the control group.

Conclusion: Although GP is not as effective as SG in terms of weight loss, it provides the same effectiveness in decreasing ghrelin and leptin levels. Histopathological findings revealed that FH, fibrosis, and the cystic glandular dilatation development rates were similar.

No MeSH data available.


Related in: MedlinePlus