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The Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults.

Kline RL, Zhang S, Farr OM, Hu S, Zaborszky L, Samanez-Larkin GR, Li CS - Front Hum Neurosci (2016)

Bottom Line: MPH reduced positive connectivity between LC and cerebellum, and induced positive connectivity between LC and right hippocampus.MPH decreased positive VTA/SNc connectivity to the cerebellum and putamen, and reduced negative connectivity to left middle occipital gyrus.MPH had distinct effects on the rsFC of BNM, LC, and VTA/SNc in healthy adults.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Yale University School of Arts and Sciences New Haven, CT, USA.

ABSTRACT

Background: Methylphenidate (MPH) influences catecholaminergic signaling. Extant work examined the effects of MPH on the neural circuits of attention and cognitive control, but few studies have investigated the effect of MPH on the brain's resting-state functional connectivity (rsFC).

Methods: In this observational study, we compared rsFC of a group of 24 healthy adults who were administered an oral 45 mg dose of MPH with a group of 24 age and gender matched controls who did not receive MPH. We focused on three seed regions: basal nucleus of Meynert (BNM), locus coeruleus (LC), and ventral tegmental area/substantia nigra, pars compacta (VTA/SNc), each providing cholinergic, noradrenergic and dopaminergic inputs to the cerebral cortex. Images were pre-processed and analyzed as in our recent work (Li et al., 2014; Zhang et al., 2015). We used one-sample t-test to characterize group-specific rsFC of each seed region and two-sample t-test to compare rsFC between groups.

Results: MPH reversed negative connectivity between BNM and precentral gyri. MPH reduced positive connectivity between LC and cerebellum, and induced positive connectivity between LC and right hippocampus. MPH decreased positive VTA/SNc connectivity to the cerebellum and putamen, and reduced negative connectivity to left middle occipital gyrus.

Conclusion: MPH had distinct effects on the rsFC of BNM, LC, and VTA/SNc in healthy adults. These new findings may further our understanding of the role of catecholaminergic signaling in Attention Deficit Hyperactivity Disorder (ADHD) and Parkinson's disease and provide insights into the therapeutic mechanisms of MPH in the treatment of clinical conditions that implicate catecholaminergic dysfunction.

No MeSH data available.


Related in: MedlinePlus

Regions with different functional connectivity to the LC. Warm colors: MPH > no-MPH; Cool colors: MPH < no-MPH; voxel p < 0.001 uncorrected; and cluster p < 0.05, FWE corrected. Color bars represent voxel T-value.
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Figure 4: Regions with different functional connectivity to the LC. Warm colors: MPH > no-MPH; Cool colors: MPH < no-MPH; voxel p < 0.001 uncorrected; and cluster p < 0.05, FWE corrected. Color bars represent voxel T-value.

Mentions: Both groups showed positive connectivity of LC with the bilateral cerebellum, with the MPH group showing significantly less positive connectivity. While the no-MPH group showed no significant connectivity of LC with the right hippocampus, the MPH group showed significant positive connectivity (Figures 2, 4; Table 1).


The Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults.

Kline RL, Zhang S, Farr OM, Hu S, Zaborszky L, Samanez-Larkin GR, Li CS - Front Hum Neurosci (2016)

Regions with different functional connectivity to the LC. Warm colors: MPH > no-MPH; Cool colors: MPH < no-MPH; voxel p < 0.001 uncorrected; and cluster p < 0.05, FWE corrected. Color bars represent voxel T-value.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834346&req=5

Figure 4: Regions with different functional connectivity to the LC. Warm colors: MPH > no-MPH; Cool colors: MPH < no-MPH; voxel p < 0.001 uncorrected; and cluster p < 0.05, FWE corrected. Color bars represent voxel T-value.
Mentions: Both groups showed positive connectivity of LC with the bilateral cerebellum, with the MPH group showing significantly less positive connectivity. While the no-MPH group showed no significant connectivity of LC with the right hippocampus, the MPH group showed significant positive connectivity (Figures 2, 4; Table 1).

Bottom Line: MPH reduced positive connectivity between LC and cerebellum, and induced positive connectivity between LC and right hippocampus.MPH decreased positive VTA/SNc connectivity to the cerebellum and putamen, and reduced negative connectivity to left middle occipital gyrus.MPH had distinct effects on the rsFC of BNM, LC, and VTA/SNc in healthy adults.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Yale University School of Arts and Sciences New Haven, CT, USA.

ABSTRACT

Background: Methylphenidate (MPH) influences catecholaminergic signaling. Extant work examined the effects of MPH on the neural circuits of attention and cognitive control, but few studies have investigated the effect of MPH on the brain's resting-state functional connectivity (rsFC).

Methods: In this observational study, we compared rsFC of a group of 24 healthy adults who were administered an oral 45 mg dose of MPH with a group of 24 age and gender matched controls who did not receive MPH. We focused on three seed regions: basal nucleus of Meynert (BNM), locus coeruleus (LC), and ventral tegmental area/substantia nigra, pars compacta (VTA/SNc), each providing cholinergic, noradrenergic and dopaminergic inputs to the cerebral cortex. Images were pre-processed and analyzed as in our recent work (Li et al., 2014; Zhang et al., 2015). We used one-sample t-test to characterize group-specific rsFC of each seed region and two-sample t-test to compare rsFC between groups.

Results: MPH reversed negative connectivity between BNM and precentral gyri. MPH reduced positive connectivity between LC and cerebellum, and induced positive connectivity between LC and right hippocampus. MPH decreased positive VTA/SNc connectivity to the cerebellum and putamen, and reduced negative connectivity to left middle occipital gyrus.

Conclusion: MPH had distinct effects on the rsFC of BNM, LC, and VTA/SNc in healthy adults. These new findings may further our understanding of the role of catecholaminergic signaling in Attention Deficit Hyperactivity Disorder (ADHD) and Parkinson's disease and provide insights into the therapeutic mechanisms of MPH in the treatment of clinical conditions that implicate catecholaminergic dysfunction.

No MeSH data available.


Related in: MedlinePlus