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pHEMA Encapsulated PEDOT-PSS-CNT Microsphere Microelectrodes for Recording Single Unit Activity in the Brain.

Castagnola E, Maggiolini E, Ceseracciu L, Ciarpella F, Zucchini E, De Faveri S, Fadiga L, Ricci D - Front Neurosci (2016)

Bottom Line: This enhancement significantly reduces the size of the implantable device though preserving excellent electrical performances.Moreover, the spherical shape of the electrode together with the surface area increase provided by the nanocomposite deposited on it, maximize the electrical contact and may improve recording stability over time.These results have a good potential to contribute to fulfill the grand challenge of obtaining stable neural interfaces for long-term applications.

View Article: PubMed Central - PubMed

Affiliation: Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia Ferrara, Italy.

ABSTRACT
The long-term reliability of neural interfaces and stability of high-quality recordings are still unsolved issues in neuroscience research. High surface area PEDOT-PSS-CNT composites are able to greatly improve the performance of recording and stimulation for traditional intracortical metal microelectrodes by decreasing their impedance and increasing their charge transfer capability. This enhancement significantly reduces the size of the implantable device though preserving excellent electrical performances. On the other hand, the presence of nanomaterials often rises concerns regarding possible health hazards, especially when considering a clinical application of the devices. For this reason, we decided to explore the problem from a new perspective by designing and testing an innovative device based on nanostructured microspheres grown on a thin tether, integrating PEDOT-PSS-CNT nanocomposites with a soft synthetic permanent biocompatible hydrogel. The pHEMA hydrogel preserves the electrochemical performance and high quality recording ability of PEDOT-PSS-CNT coated devices, reduces the mechanical mismatch between soft brain tissue and stiff devices and also avoids direct contact between the neural tissue and the nanocomposite, by acting as a biocompatible protective barrier against potential nanomaterial detachment. Moreover, the spherical shape of the electrode together with the surface area increase provided by the nanocomposite deposited on it, maximize the electrical contact and may improve recording stability over time. These results have a good potential to contribute to fulfill the grand challenge of obtaining stable neural interfaces for long-term applications.

No MeSH data available.


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SPDs obtained for the non-filtered spontaneous activity recorded from the rat brain using non-encapsulated PEDOT-PSS-CNT (A) and pHEMA-encapsulated (B) microspheres at 1, 7, 14, 21, and 28 days after the implant.
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Figure 7: SPDs obtained for the non-filtered spontaneous activity recorded from the rat brain using non-encapsulated PEDOT-PSS-CNT (A) and pHEMA-encapsulated (B) microspheres at 1, 7, 14, 21, and 28 days after the implant.

Mentions: The same results are confirmed by the SPDs (Figure 7) obtained for 10 seconds of the non-filtered spontaneous activity recorded from the same animal using PEDOT-PSS- non-encapsulated CNT microspheres (Figure 7A) and pHEMA-encapsulated (Figure 7B) microspheres at 1, 7, 14, 21, and 28 days after the implant. An example of signal power values over the spike frequency range, computed as the integral of the SPDs of the signals between 250 and 3000 Hz -the frequency range where spikes of individual neurons can be detected- is reported in Supplementary Table 2S. After 28 days both encapsulated and non-encapsulated electrodes were still able to record high-quality spiking activity.


pHEMA Encapsulated PEDOT-PSS-CNT Microsphere Microelectrodes for Recording Single Unit Activity in the Brain.

Castagnola E, Maggiolini E, Ceseracciu L, Ciarpella F, Zucchini E, De Faveri S, Fadiga L, Ricci D - Front Neurosci (2016)

SPDs obtained for the non-filtered spontaneous activity recorded from the rat brain using non-encapsulated PEDOT-PSS-CNT (A) and pHEMA-encapsulated (B) microspheres at 1, 7, 14, 21, and 28 days after the implant.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834343&req=5

Figure 7: SPDs obtained for the non-filtered spontaneous activity recorded from the rat brain using non-encapsulated PEDOT-PSS-CNT (A) and pHEMA-encapsulated (B) microspheres at 1, 7, 14, 21, and 28 days after the implant.
Mentions: The same results are confirmed by the SPDs (Figure 7) obtained for 10 seconds of the non-filtered spontaneous activity recorded from the same animal using PEDOT-PSS- non-encapsulated CNT microspheres (Figure 7A) and pHEMA-encapsulated (Figure 7B) microspheres at 1, 7, 14, 21, and 28 days after the implant. An example of signal power values over the spike frequency range, computed as the integral of the SPDs of the signals between 250 and 3000 Hz -the frequency range where spikes of individual neurons can be detected- is reported in Supplementary Table 2S. After 28 days both encapsulated and non-encapsulated electrodes were still able to record high-quality spiking activity.

Bottom Line: This enhancement significantly reduces the size of the implantable device though preserving excellent electrical performances.Moreover, the spherical shape of the electrode together with the surface area increase provided by the nanocomposite deposited on it, maximize the electrical contact and may improve recording stability over time.These results have a good potential to contribute to fulfill the grand challenge of obtaining stable neural interfaces for long-term applications.

View Article: PubMed Central - PubMed

Affiliation: Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia Ferrara, Italy.

ABSTRACT
The long-term reliability of neural interfaces and stability of high-quality recordings are still unsolved issues in neuroscience research. High surface area PEDOT-PSS-CNT composites are able to greatly improve the performance of recording and stimulation for traditional intracortical metal microelectrodes by decreasing their impedance and increasing their charge transfer capability. This enhancement significantly reduces the size of the implantable device though preserving excellent electrical performances. On the other hand, the presence of nanomaterials often rises concerns regarding possible health hazards, especially when considering a clinical application of the devices. For this reason, we decided to explore the problem from a new perspective by designing and testing an innovative device based on nanostructured microspheres grown on a thin tether, integrating PEDOT-PSS-CNT nanocomposites with a soft synthetic permanent biocompatible hydrogel. The pHEMA hydrogel preserves the electrochemical performance and high quality recording ability of PEDOT-PSS-CNT coated devices, reduces the mechanical mismatch between soft brain tissue and stiff devices and also avoids direct contact between the neural tissue and the nanocomposite, by acting as a biocompatible protective barrier against potential nanomaterial detachment. Moreover, the spherical shape of the electrode together with the surface area increase provided by the nanocomposite deposited on it, maximize the electrical contact and may improve recording stability over time. These results have a good potential to contribute to fulfill the grand challenge of obtaining stable neural interfaces for long-term applications.

No MeSH data available.


Related in: MedlinePlus