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pHEMA Encapsulated PEDOT-PSS-CNT Microsphere Microelectrodes for Recording Single Unit Activity in the Brain.

Castagnola E, Maggiolini E, Ceseracciu L, Ciarpella F, Zucchini E, De Faveri S, Fadiga L, Ricci D - Front Neurosci (2016)

Bottom Line: This enhancement significantly reduces the size of the implantable device though preserving excellent electrical performances.Moreover, the spherical shape of the electrode together with the surface area increase provided by the nanocomposite deposited on it, maximize the electrical contact and may improve recording stability over time.These results have a good potential to contribute to fulfill the grand challenge of obtaining stable neural interfaces for long-term applications.

View Article: PubMed Central - PubMed

Affiliation: Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia Ferrara, Italy.

ABSTRACT
The long-term reliability of neural interfaces and stability of high-quality recordings are still unsolved issues in neuroscience research. High surface area PEDOT-PSS-CNT composites are able to greatly improve the performance of recording and stimulation for traditional intracortical metal microelectrodes by decreasing their impedance and increasing their charge transfer capability. This enhancement significantly reduces the size of the implantable device though preserving excellent electrical performances. On the other hand, the presence of nanomaterials often rises concerns regarding possible health hazards, especially when considering a clinical application of the devices. For this reason, we decided to explore the problem from a new perspective by designing and testing an innovative device based on nanostructured microspheres grown on a thin tether, integrating PEDOT-PSS-CNT nanocomposites with a soft synthetic permanent biocompatible hydrogel. The pHEMA hydrogel preserves the electrochemical performance and high quality recording ability of PEDOT-PSS-CNT coated devices, reduces the mechanical mismatch between soft brain tissue and stiff devices and also avoids direct contact between the neural tissue and the nanocomposite, by acting as a biocompatible protective barrier against potential nanomaterial detachment. Moreover, the spherical shape of the electrode together with the surface area increase provided by the nanocomposite deposited on it, maximize the electrical contact and may improve recording stability over time. These results have a good potential to contribute to fulfill the grand challenge of obtaining stable neural interfaces for long-term applications.

No MeSH data available.


Related in: MedlinePlus

Representative SEM images of (A,B) platinum wire before deposition (lateral and frontal view), (C) gold microsphere, and (D) PEDOT-PSS-CNT coated microsphere. Higher magnification images of the surface morphology of (E) nanostructured gold and of (F) PEDOT-PSS-CNT composite obtained by Zeiss EVO 40 SEM. High resolution images of (G,H) PEDOT-PSS-CNT composite obtained by Jeol JSM-7500FA FEG-SEM.
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Figure 2: Representative SEM images of (A,B) platinum wire before deposition (lateral and frontal view), (C) gold microsphere, and (D) PEDOT-PSS-CNT coated microsphere. Higher magnification images of the surface morphology of (E) nanostructured gold and of (F) PEDOT-PSS-CNT composite obtained by Zeiss EVO 40 SEM. High resolution images of (G,H) PEDOT-PSS-CNT composite obtained by Jeol JSM-7500FA FEG-SEM.

Mentions: SEM images of a platinum wire at beginning of the process (Figures 2A,B) after microsphere growth (Figure 2C,E) and after PEDOT-PSS-CNT coating (Figure 2D) are reported. Higher resolution imaging of PEDOT-PSS-CNT coated microspheres obtained with scanning electron microscopes having different performance, (Figure 2F) and (Figures 2G,H), shows the emergence of the fine nanoscale CNT scaffold structure, similar to what already demonstrated on flat electrode surfaces (Castagnola et al., 2013).


pHEMA Encapsulated PEDOT-PSS-CNT Microsphere Microelectrodes for Recording Single Unit Activity in the Brain.

Castagnola E, Maggiolini E, Ceseracciu L, Ciarpella F, Zucchini E, De Faveri S, Fadiga L, Ricci D - Front Neurosci (2016)

Representative SEM images of (A,B) platinum wire before deposition (lateral and frontal view), (C) gold microsphere, and (D) PEDOT-PSS-CNT coated microsphere. Higher magnification images of the surface morphology of (E) nanostructured gold and of (F) PEDOT-PSS-CNT composite obtained by Zeiss EVO 40 SEM. High resolution images of (G,H) PEDOT-PSS-CNT composite obtained by Jeol JSM-7500FA FEG-SEM.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834343&req=5

Figure 2: Representative SEM images of (A,B) platinum wire before deposition (lateral and frontal view), (C) gold microsphere, and (D) PEDOT-PSS-CNT coated microsphere. Higher magnification images of the surface morphology of (E) nanostructured gold and of (F) PEDOT-PSS-CNT composite obtained by Zeiss EVO 40 SEM. High resolution images of (G,H) PEDOT-PSS-CNT composite obtained by Jeol JSM-7500FA FEG-SEM.
Mentions: SEM images of a platinum wire at beginning of the process (Figures 2A,B) after microsphere growth (Figure 2C,E) and after PEDOT-PSS-CNT coating (Figure 2D) are reported. Higher resolution imaging of PEDOT-PSS-CNT coated microspheres obtained with scanning electron microscopes having different performance, (Figure 2F) and (Figures 2G,H), shows the emergence of the fine nanoscale CNT scaffold structure, similar to what already demonstrated on flat electrode surfaces (Castagnola et al., 2013).

Bottom Line: This enhancement significantly reduces the size of the implantable device though preserving excellent electrical performances.Moreover, the spherical shape of the electrode together with the surface area increase provided by the nanocomposite deposited on it, maximize the electrical contact and may improve recording stability over time.These results have a good potential to contribute to fulfill the grand challenge of obtaining stable neural interfaces for long-term applications.

View Article: PubMed Central - PubMed

Affiliation: Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia Ferrara, Italy.

ABSTRACT
The long-term reliability of neural interfaces and stability of high-quality recordings are still unsolved issues in neuroscience research. High surface area PEDOT-PSS-CNT composites are able to greatly improve the performance of recording and stimulation for traditional intracortical metal microelectrodes by decreasing their impedance and increasing their charge transfer capability. This enhancement significantly reduces the size of the implantable device though preserving excellent electrical performances. On the other hand, the presence of nanomaterials often rises concerns regarding possible health hazards, especially when considering a clinical application of the devices. For this reason, we decided to explore the problem from a new perspective by designing and testing an innovative device based on nanostructured microspheres grown on a thin tether, integrating PEDOT-PSS-CNT nanocomposites with a soft synthetic permanent biocompatible hydrogel. The pHEMA hydrogel preserves the electrochemical performance and high quality recording ability of PEDOT-PSS-CNT coated devices, reduces the mechanical mismatch between soft brain tissue and stiff devices and also avoids direct contact between the neural tissue and the nanocomposite, by acting as a biocompatible protective barrier against potential nanomaterial detachment. Moreover, the spherical shape of the electrode together with the surface area increase provided by the nanocomposite deposited on it, maximize the electrical contact and may improve recording stability over time. These results have a good potential to contribute to fulfill the grand challenge of obtaining stable neural interfaces for long-term applications.

No MeSH data available.


Related in: MedlinePlus