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Maternal high-fat hypercaloric diet during pregnancy results in persistent metabolic and respiratory abnormalities in offspring.

Griffiths PS, Walton C, Samsell L, Perez MK, Piedimonte G - Pediatr. Res. (2015)

Bottom Line: Gene expression of neurotrophic factors and receptors was upregulated in lungs of weanlings born to HFD dams, and this was associated to higher respiratory system resistance and lower compliance at baseline, as well as hyperreactivity to aerosolized methacholine.Furthermore, HFD dams delivered pups prone to develop more severe disease after respiratory syncytial virus (RSV) infection.Maternal nutrition in pregnancy is a critical determinant of airway inflammation and hyperreactivity in offspring and also increases risk for bronchiolitis independent from prepregnancy nutrition.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, West Virginia University, Morgantown, West Virginia.

ABSTRACT

Background: We have shown in a previous population-based study significant correlation between childhood asthma and early abnormalities of lipid and glucose metabolism. This study's specific aim was to determine whether maternal nutrition in pregnancy affects postnatal metabolic and respiratory outcomes in the offspring.

Methods: On gestation day 1, dams were switched from standard chow to either high-fat hypercaloric diet or control diet. Terminal experiments were performed on newborn and weanling offspring of dams fed the study diet during gestation and lactation, and on adult offspring maintained on the same diet as their mother.

Results: Pups born from high-fat hypercaloric diet (HFD) dams developed metabolic abnormalities persistent throughout development. Cytokine expression analysis of lung tissues from newborns born to HFD dams revealed a strong proinflammatory pattern. Gene expression of neurotrophic factors and receptors was upregulated in lungs of weanlings born to HFD dams, and this was associated to higher respiratory system resistance and lower compliance at baseline, as well as hyperreactivity to aerosolized methacholine. Furthermore, HFD dams delivered pups prone to develop more severe disease after respiratory syncytial virus (RSV) infection.

Conclusion: Maternal nutrition in pregnancy is a critical determinant of airway inflammation and hyperreactivity in offspring and also increases risk for bronchiolitis independent from prepregnancy nutrition.

No MeSH data available.


Related in: MedlinePlus

Effect of maternal diet on pulmonary function of weanlings. Weanlings born to dams fed high-fat hypercaloric diet (HFD) during pregnancy (solid circles) had significantly higher (a) respiratory system resistance (Rrs) and lower (b) respiratory system compliance (Crs) at baseline compared with age-matched controls born to dams fed a normal diet (open circles). Following challenge with aerosolized methacholine, significantly higher airway resistance and lower lung compliance were observed in HFD offspring. Data are expressed as mean ± SEM (n = 7 rats per group). *P < 0.05; **P < 0.01 compared with age-matched controls born to dams fed with control diet.
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fig2: Effect of maternal diet on pulmonary function of weanlings. Weanlings born to dams fed high-fat hypercaloric diet (HFD) during pregnancy (solid circles) had significantly higher (a) respiratory system resistance (Rrs) and lower (b) respiratory system compliance (Crs) at baseline compared with age-matched controls born to dams fed a normal diet (open circles). Following challenge with aerosolized methacholine, significantly higher airway resistance and lower lung compliance were observed in HFD offspring. Data are expressed as mean ± SEM (n = 7 rats per group). *P < 0.05; **P < 0.01 compared with age-matched controls born to dams fed with control diet.

Mentions: In previous studies performed in the same animal model, we have shown that the neurotrophic pathways described above control airway smooth muscle tone and contraction in response to electrical and cholinergic stimulation. Consistently, weanlings born to HFD dams had significantly higher respiratory system resistance (Rrs; P < 0.01) and lower respiratory system compliance (Crs; P < 0.001) at baseline compared with age-matched controls born to CD dams (Figure 2; n = 7 per group). Following challenge with aerosolized methacholine, significantly higher airway resistance and lower lung compliance were observed in HFD offspring with cumulative doses up to 8.75 mg/ml. In adult offspring, there were no significant differences in baseline resistance or compliance, but Rrs increased significantly more in offspring from HFD mothers in response to inhaled methacholine at a cumulative dose of 3.5 mg/ml (P < 0.05).


Maternal high-fat hypercaloric diet during pregnancy results in persistent metabolic and respiratory abnormalities in offspring.

Griffiths PS, Walton C, Samsell L, Perez MK, Piedimonte G - Pediatr. Res. (2015)

Effect of maternal diet on pulmonary function of weanlings. Weanlings born to dams fed high-fat hypercaloric diet (HFD) during pregnancy (solid circles) had significantly higher (a) respiratory system resistance (Rrs) and lower (b) respiratory system compliance (Crs) at baseline compared with age-matched controls born to dams fed a normal diet (open circles). Following challenge with aerosolized methacholine, significantly higher airway resistance and lower lung compliance were observed in HFD offspring. Data are expressed as mean ± SEM (n = 7 rats per group). *P < 0.05; **P < 0.01 compared with age-matched controls born to dams fed with control diet.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4829879&req=5

fig2: Effect of maternal diet on pulmonary function of weanlings. Weanlings born to dams fed high-fat hypercaloric diet (HFD) during pregnancy (solid circles) had significantly higher (a) respiratory system resistance (Rrs) and lower (b) respiratory system compliance (Crs) at baseline compared with age-matched controls born to dams fed a normal diet (open circles). Following challenge with aerosolized methacholine, significantly higher airway resistance and lower lung compliance were observed in HFD offspring. Data are expressed as mean ± SEM (n = 7 rats per group). *P < 0.05; **P < 0.01 compared with age-matched controls born to dams fed with control diet.
Mentions: In previous studies performed in the same animal model, we have shown that the neurotrophic pathways described above control airway smooth muscle tone and contraction in response to electrical and cholinergic stimulation. Consistently, weanlings born to HFD dams had significantly higher respiratory system resistance (Rrs; P < 0.01) and lower respiratory system compliance (Crs; P < 0.001) at baseline compared with age-matched controls born to CD dams (Figure 2; n = 7 per group). Following challenge with aerosolized methacholine, significantly higher airway resistance and lower lung compliance were observed in HFD offspring with cumulative doses up to 8.75 mg/ml. In adult offspring, there were no significant differences in baseline resistance or compliance, but Rrs increased significantly more in offspring from HFD mothers in response to inhaled methacholine at a cumulative dose of 3.5 mg/ml (P < 0.05).

Bottom Line: Gene expression of neurotrophic factors and receptors was upregulated in lungs of weanlings born to HFD dams, and this was associated to higher respiratory system resistance and lower compliance at baseline, as well as hyperreactivity to aerosolized methacholine.Furthermore, HFD dams delivered pups prone to develop more severe disease after respiratory syncytial virus (RSV) infection.Maternal nutrition in pregnancy is a critical determinant of airway inflammation and hyperreactivity in offspring and also increases risk for bronchiolitis independent from prepregnancy nutrition.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, West Virginia University, Morgantown, West Virginia.

ABSTRACT

Background: We have shown in a previous population-based study significant correlation between childhood asthma and early abnormalities of lipid and glucose metabolism. This study's specific aim was to determine whether maternal nutrition in pregnancy affects postnatal metabolic and respiratory outcomes in the offspring.

Methods: On gestation day 1, dams were switched from standard chow to either high-fat hypercaloric diet or control diet. Terminal experiments were performed on newborn and weanling offspring of dams fed the study diet during gestation and lactation, and on adult offspring maintained on the same diet as their mother.

Results: Pups born from high-fat hypercaloric diet (HFD) dams developed metabolic abnormalities persistent throughout development. Cytokine expression analysis of lung tissues from newborns born to HFD dams revealed a strong proinflammatory pattern. Gene expression of neurotrophic factors and receptors was upregulated in lungs of weanlings born to HFD dams, and this was associated to higher respiratory system resistance and lower compliance at baseline, as well as hyperreactivity to aerosolized methacholine. Furthermore, HFD dams delivered pups prone to develop more severe disease after respiratory syncytial virus (RSV) infection.

Conclusion: Maternal nutrition in pregnancy is a critical determinant of airway inflammation and hyperreactivity in offspring and also increases risk for bronchiolitis independent from prepregnancy nutrition.

No MeSH data available.


Related in: MedlinePlus