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The modulatory influence of some Echinacea-based remedies on antibody production and cellular immunity in mice.

Bałan BJ, Sokolnicka I, Skopińska-Różewska E, Skopiński P - Cent Eur J Immunol (2016)

Bottom Line: Feeding mice for seven days with IMMUNAL drops resulted in enhanced anti-SRBC antibody production and modulatory effect on proliferative response to PHA of their splenic lymphocytes.No stimulatory effect was observed on splenocytes chemokinesis.Lymphocyte-induced immunological angiogenesis activity of splenocytes collected from animals fed with prophylactic and therapeutic IMMUNAL FORTE tablet doses did not differ from the controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, Poland.

ABSTRACT

Unlabelled: Echinacea purpurea-containing remedies are herbal medicines used in respiratory tract infections and several inflammatory conditions as enhancers of non-specific and modulators of specific cellular immunity. They also exert anti-inflammatory, anti-viral, and anti-microbial activity. The aim of the present study was to compare the in vivo influence of orally administered three Echinacea purpurea-based remedies (IMMUNAL drops, ECHINACEA FORTE drops, IMMUNAL FORTE tablets) on some parameters of cellular and humoral immunity in mice.

Results: Feeding mice for seven days with IMMUNAL drops resulted in enhanced anti-SRBC antibody production and modulatory effect on proliferative response to PHA of their splenic lymphocytes. No stimulatory effect was observed on splenocytes chemokinesis. Mice fed with ECHINACEA FORTE drops presented enhanced response to PHA of their splenocytes. However, contrary to the previous group, no enhancement of antibody production was observed. In this group, lymphocyte-induced immunological angiogenesis (LIA) and chemokinesis (spontaneous migration - SM) of spleen lymphocytes was diminished after feeding mice with both doses (LIA) or with a higher dose (SM) of remedy. Lymphocyte-induced immunological angiogenesis activity of splenocytes collected from animals fed with prophylactic and therapeutic IMMUNAL FORTE tablet doses did not differ from the controls.

No MeSH data available.


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Stimulatory effect of IMMUNAL drops on the anti-SRBC antibody production
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Figure 0001: Stimulatory effect of IMMUNAL drops on the anti-SRBC antibody production

Mentions: Feeding mice for seven days with 6 or 12 µl of Echinacea purpurea succus stabilised with alcohol (IMMUNAL drops) resulted in enhanced anti-SRBC antibody production (Fig. 1) and modulated (enhanced in lower concentration of mitogen, suppressed in higher) proliferative response to PHA of their splenic lymphocytes (Fig. 2). No stimulatory effect was observed on splenocytes chemokinesis (Fig. 3). Mice fed another formulation of Echinacea purpurea succus stabilised with alcohol (ECHINACEA FORTE drops) presented enhanced response to PHA of their splenocytes. However, contrary to the previous group, no enhancement of antibody production was observed. In this group, lymphocyte-induced immunological angiogenesis (LIA) and chemokinesis (spontaneous migration – SM) of spleen lymphocytes was diminished after feeding mice with both doses (LIA) or with higher dose (SM) of remedy (Figs. 4–7). LIA activity of splenocytes collected from animals fed with prophylactic and therapeutic doses of IMMUNAL FORTE tablets did not differ from the controls (Fig. 8).


The modulatory influence of some Echinacea-based remedies on antibody production and cellular immunity in mice.

Bałan BJ, Sokolnicka I, Skopińska-Różewska E, Skopiński P - Cent Eur J Immunol (2016)

Stimulatory effect of IMMUNAL drops on the anti-SRBC antibody production
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4829818&req=5

Figure 0001: Stimulatory effect of IMMUNAL drops on the anti-SRBC antibody production
Mentions: Feeding mice for seven days with 6 or 12 µl of Echinacea purpurea succus stabilised with alcohol (IMMUNAL drops) resulted in enhanced anti-SRBC antibody production (Fig. 1) and modulated (enhanced in lower concentration of mitogen, suppressed in higher) proliferative response to PHA of their splenic lymphocytes (Fig. 2). No stimulatory effect was observed on splenocytes chemokinesis (Fig. 3). Mice fed another formulation of Echinacea purpurea succus stabilised with alcohol (ECHINACEA FORTE drops) presented enhanced response to PHA of their splenocytes. However, contrary to the previous group, no enhancement of antibody production was observed. In this group, lymphocyte-induced immunological angiogenesis (LIA) and chemokinesis (spontaneous migration – SM) of spleen lymphocytes was diminished after feeding mice with both doses (LIA) or with higher dose (SM) of remedy (Figs. 4–7). LIA activity of splenocytes collected from animals fed with prophylactic and therapeutic doses of IMMUNAL FORTE tablets did not differ from the controls (Fig. 8).

Bottom Line: Feeding mice for seven days with IMMUNAL drops resulted in enhanced anti-SRBC antibody production and modulatory effect on proliferative response to PHA of their splenic lymphocytes.No stimulatory effect was observed on splenocytes chemokinesis.Lymphocyte-induced immunological angiogenesis activity of splenocytes collected from animals fed with prophylactic and therapeutic IMMUNAL FORTE tablet doses did not differ from the controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, Poland.

ABSTRACT

Unlabelled: Echinacea purpurea-containing remedies are herbal medicines used in respiratory tract infections and several inflammatory conditions as enhancers of non-specific and modulators of specific cellular immunity. They also exert anti-inflammatory, anti-viral, and anti-microbial activity. The aim of the present study was to compare the in vivo influence of orally administered three Echinacea purpurea-based remedies (IMMUNAL drops, ECHINACEA FORTE drops, IMMUNAL FORTE tablets) on some parameters of cellular and humoral immunity in mice.

Results: Feeding mice for seven days with IMMUNAL drops resulted in enhanced anti-SRBC antibody production and modulatory effect on proliferative response to PHA of their splenic lymphocytes. No stimulatory effect was observed on splenocytes chemokinesis. Mice fed with ECHINACEA FORTE drops presented enhanced response to PHA of their splenocytes. However, contrary to the previous group, no enhancement of antibody production was observed. In this group, lymphocyte-induced immunological angiogenesis (LIA) and chemokinesis (spontaneous migration - SM) of spleen lymphocytes was diminished after feeding mice with both doses (LIA) or with a higher dose (SM) of remedy. Lymphocyte-induced immunological angiogenesis activity of splenocytes collected from animals fed with prophylactic and therapeutic IMMUNAL FORTE tablet doses did not differ from the controls.

No MeSH data available.


Related in: MedlinePlus