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Gait Changes Vary among Horses with Naturally Occurring Osteoarthritis Following Intra-articular Administration of Autologous Platelet-Rich Plasma.

Mirza MH, Bommala P, Richbourg HA, Rademacher N, Kearney MT, Lopez MJ - Front Vet Sci (2016)

Bottom Line: Statistical evaluations included filtration effect on platelet concentration, relationship between kinetic variable changes after IAA versus PRP in the affected limb, and associations between response to PRP and response to IAA, platelet concentration, and radiographic OA.Filtration increased platelet concentration significantly.The relationship between kinetic variable alterations of the affected limb after IAA and PRP was not significant, and response to PRP was not associated with response to IAA, platelet concentration, or radiographic OA.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA , USA.

ABSTRACT
Mechanisms to reduce lameness associated with osteoarthritis (OA) are vital to equine health and performance. This study was designed to quantify response to autologous, intra-articular platelet-rich plasma (PRP) in horses with OA. Kinetic gait analysis was performed on 12 horses with unilateral forelimb lameness and OA in the same limb before and after intra-articular anesthesia (IAA). Radiographs and kinetic data were obtained before and 6 and 16 weeks after PRP administration to same joint, 4 weeks after IAA. Statistical evaluations included filtration effect on platelet concentration, relationship between kinetic variable changes after IAA versus PRP in the affected limb, and associations between response to PRP and response to IAA, platelet concentration, and radiographic OA. A positive response to IAA or PRP was defined as ≥5% improvement in peak vertical force, vertical impulse, or breaking impulse of the affected limb. Out of 10 horses that responded to IAA, 3 responded to PRP at both time points and 4 responded at one. Of the two horses that did not respond to IAA, one responded to PRP at both time points. Filtration increased platelet concentration significantly. The relationship between kinetic variable alterations of the affected limb after IAA and PRP was not significant, and response to PRP was not associated with response to IAA, platelet concentration, or radiographic OA. Changes in kinetic variables following IAA in joints with naturally occurring OA provide a custom standard to assess intra-articular therapy. Kinetic gait changes after intra-articular PRP are variable in horses with moderate to severe forelimb OA.

No MeSH data available.


Related in: MedlinePlus

Percent change (mean ± SD) in PVFZ, IMPZ, and IMPB of the affected limb for horses that did not respond to IAA and (A) responded to PRP after 6 weeks, (B) responded to PRP after 16 weeks, (C) did not respond to PRP after 6 weeks, and (D) did not respond to PRP after 16 weeks.
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Figure 5: Percent change (mean ± SD) in PVFZ, IMPZ, and IMPB of the affected limb for horses that did not respond to IAA and (A) responded to PRP after 6 weeks, (B) responded to PRP after 16 weeks, (C) did not respond to PRP after 6 weeks, and (D) did not respond to PRP after 16 weeks.

Mentions: Within those horses that responded positively to IAA (n = 10), three responded positively to PRP 6 and 16 weeks after administration, and four responded at one time point only, either 6 or 16 weeks (Figure 4). Of the horses that did not respond to IAA, one responded to PRP treatment at both time points (Figure 5). The association between response to IAA and response to PRP was not significant.


Gait Changes Vary among Horses with Naturally Occurring Osteoarthritis Following Intra-articular Administration of Autologous Platelet-Rich Plasma.

Mirza MH, Bommala P, Richbourg HA, Rademacher N, Kearney MT, Lopez MJ - Front Vet Sci (2016)

Percent change (mean ± SD) in PVFZ, IMPZ, and IMPB of the affected limb for horses that did not respond to IAA and (A) responded to PRP after 6 weeks, (B) responded to PRP after 16 weeks, (C) did not respond to PRP after 6 weeks, and (D) did not respond to PRP after 16 weeks.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4829588&req=5

Figure 5: Percent change (mean ± SD) in PVFZ, IMPZ, and IMPB of the affected limb for horses that did not respond to IAA and (A) responded to PRP after 6 weeks, (B) responded to PRP after 16 weeks, (C) did not respond to PRP after 6 weeks, and (D) did not respond to PRP after 16 weeks.
Mentions: Within those horses that responded positively to IAA (n = 10), three responded positively to PRP 6 and 16 weeks after administration, and four responded at one time point only, either 6 or 16 weeks (Figure 4). Of the horses that did not respond to IAA, one responded to PRP treatment at both time points (Figure 5). The association between response to IAA and response to PRP was not significant.

Bottom Line: Statistical evaluations included filtration effect on platelet concentration, relationship between kinetic variable changes after IAA versus PRP in the affected limb, and associations between response to PRP and response to IAA, platelet concentration, and radiographic OA.Filtration increased platelet concentration significantly.The relationship between kinetic variable alterations of the affected limb after IAA and PRP was not significant, and response to PRP was not associated with response to IAA, platelet concentration, or radiographic OA.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA , USA.

ABSTRACT
Mechanisms to reduce lameness associated with osteoarthritis (OA) are vital to equine health and performance. This study was designed to quantify response to autologous, intra-articular platelet-rich plasma (PRP) in horses with OA. Kinetic gait analysis was performed on 12 horses with unilateral forelimb lameness and OA in the same limb before and after intra-articular anesthesia (IAA). Radiographs and kinetic data were obtained before and 6 and 16 weeks after PRP administration to same joint, 4 weeks after IAA. Statistical evaluations included filtration effect on platelet concentration, relationship between kinetic variable changes after IAA versus PRP in the affected limb, and associations between response to PRP and response to IAA, platelet concentration, and radiographic OA. A positive response to IAA or PRP was defined as ≥5% improvement in peak vertical force, vertical impulse, or breaking impulse of the affected limb. Out of 10 horses that responded to IAA, 3 responded to PRP at both time points and 4 responded at one. Of the two horses that did not respond to IAA, one responded to PRP at both time points. Filtration increased platelet concentration significantly. The relationship between kinetic variable alterations of the affected limb after IAA and PRP was not significant, and response to PRP was not associated with response to IAA, platelet concentration, or radiographic OA. Changes in kinetic variables following IAA in joints with naturally occurring OA provide a custom standard to assess intra-articular therapy. Kinetic gait changes after intra-articular PRP are variable in horses with moderate to severe forelimb OA.

No MeSH data available.


Related in: MedlinePlus