Limits...
Effect of Ulcerative Colitis on Incidence of Colorectal Cancer: Results from the Nationwide Population-Based Cohort Study (2003-2013).

Choi JK, Kim DW, Shin SY, Park EC, Kang JG - J Cancer (2016)

Bottom Line: The effects were stronger for male.Furthermore, the effects of UC in male patients are higher than those in female.The future study is needed to identify the effect of UC on mortality of CRC.

View Article: PubMed Central - PubMed

Affiliation: 1. Institute of Health Insurance & Clinical Research, National Health Insurance Service Ilsan Hospital, Goyang, Korea.

ABSTRACT

Purpose: The colorectal cancer (CRC) is the third leading cause of death in Korea. Ulcerative colitis (UC) is regarded as a risk factor of CRC. The aim of study is to confirm the incidence of CRC among subjects with and without a diagnosis of UC based on a sample of the Korean population. This study identified the effect of UC on incidence of CRC in Korea.

Method: The data were from the population-based cohort containing National Health Insurance (NHI) claims from 2002 to 2013. We washed out first year (2002) for newly detected cases. Subjects who were under 20 years of age, diagnosed UC and CRC in 2002 development of CRC before diagnosis of UC since 2003, were excluded from analyses. Among 745,641 subjects during 11 years of follow-up (2003-2013), 7,448 patients with CRC were newly detected. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of UC for CRC incidence. Confounding variables including gender, baseline age, type of social security, income level, residence, Charlson Comorbidity Index, hypertension and diabetes mellitus were incorporated into the model.

Results: Overall annual incidence of UC and CRC were 6.7 and 95.4 per 100,000 during 11 years (2003~2013), respectively. Among 522 of newly detected UC cases, CRC incident cases were 12 cases during 11 years. The effects were stronger for male. Advancing age and Charlson Comorbidity Index, hypertension and diabetes mellitus increased the risk of CRC. This study showed that the adjusted hazard ratio of UC in incidence of CRC is 1.92 (95% confidence interval: 1.09-3.38). Also, male patients with UC have more HR than female patients with UC.

Conclusion: The results of this study showed that patients with UC are the high risk group in incidence of CRC. Furthermore, the effects of UC in male patients are higher than those in female. The future study is needed to identify the effect of UC on mortality of CRC.

No MeSH data available.


Related in: MedlinePlus

Difference in development of CRC according to diagnosis of UC
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4829554&req=5

Figure 2: Difference in development of CRC according to diagnosis of UC

Mentions: Baseline characteristics of subjects were shown according to incidence of CRC (Table 1). There were 7,448 new cases of CRC during 11 years (2003~2013), 4,204 of which occurred in male and 3,244 of which occurred in female. The incidence of CRC was higher in male than in female. CRC developed in 2.3% of the UC group and 1.0% in the non-UC group. Figure 2 shows the difference in development of CRC according to diagnosis of UC. Risk of CRC was over 2 fold higher in subjects with UC. The incidence of UC was 6.7 per 100,000 from 2003 to 2013. The incidence of CRC was 95.4 per 100,000 from 2003 to 2013. 12 of the patients with UC (n=522) were diagnosed CRC. Overall, annual incidence of CRC in male and female were 110.2 and 81.2 per 100,000. Average durations at CRC diagnosis of patients with UC were 3.39 year.


Effect of Ulcerative Colitis on Incidence of Colorectal Cancer: Results from the Nationwide Population-Based Cohort Study (2003-2013).

Choi JK, Kim DW, Shin SY, Park EC, Kang JG - J Cancer (2016)

Difference in development of CRC according to diagnosis of UC
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4829554&req=5

Figure 2: Difference in development of CRC according to diagnosis of UC
Mentions: Baseline characteristics of subjects were shown according to incidence of CRC (Table 1). There were 7,448 new cases of CRC during 11 years (2003~2013), 4,204 of which occurred in male and 3,244 of which occurred in female. The incidence of CRC was higher in male than in female. CRC developed in 2.3% of the UC group and 1.0% in the non-UC group. Figure 2 shows the difference in development of CRC according to diagnosis of UC. Risk of CRC was over 2 fold higher in subjects with UC. The incidence of UC was 6.7 per 100,000 from 2003 to 2013. The incidence of CRC was 95.4 per 100,000 from 2003 to 2013. 12 of the patients with UC (n=522) were diagnosed CRC. Overall, annual incidence of CRC in male and female were 110.2 and 81.2 per 100,000. Average durations at CRC diagnosis of patients with UC were 3.39 year.

Bottom Line: The effects were stronger for male.Furthermore, the effects of UC in male patients are higher than those in female.The future study is needed to identify the effect of UC on mortality of CRC.

View Article: PubMed Central - PubMed

Affiliation: 1. Institute of Health Insurance & Clinical Research, National Health Insurance Service Ilsan Hospital, Goyang, Korea.

ABSTRACT

Purpose: The colorectal cancer (CRC) is the third leading cause of death in Korea. Ulcerative colitis (UC) is regarded as a risk factor of CRC. The aim of study is to confirm the incidence of CRC among subjects with and without a diagnosis of UC based on a sample of the Korean population. This study identified the effect of UC on incidence of CRC in Korea.

Method: The data were from the population-based cohort containing National Health Insurance (NHI) claims from 2002 to 2013. We washed out first year (2002) for newly detected cases. Subjects who were under 20 years of age, diagnosed UC and CRC in 2002 development of CRC before diagnosis of UC since 2003, were excluded from analyses. Among 745,641 subjects during 11 years of follow-up (2003-2013), 7,448 patients with CRC were newly detected. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of UC for CRC incidence. Confounding variables including gender, baseline age, type of social security, income level, residence, Charlson Comorbidity Index, hypertension and diabetes mellitus were incorporated into the model.

Results: Overall annual incidence of UC and CRC were 6.7 and 95.4 per 100,000 during 11 years (2003~2013), respectively. Among 522 of newly detected UC cases, CRC incident cases were 12 cases during 11 years. The effects were stronger for male. Advancing age and Charlson Comorbidity Index, hypertension and diabetes mellitus increased the risk of CRC. This study showed that the adjusted hazard ratio of UC in incidence of CRC is 1.92 (95% confidence interval: 1.09-3.38). Also, male patients with UC have more HR than female patients with UC.

Conclusion: The results of this study showed that patients with UC are the high risk group in incidence of CRC. Furthermore, the effects of UC in male patients are higher than those in female. The future study is needed to identify the effect of UC on mortality of CRC.

No MeSH data available.


Related in: MedlinePlus