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The clinical significance of preoperative serum cholesterol and high-density lipoprotein-cholesterol levels in hepatocellular carcinoma.

Jiang SS, Weng DS, Jiang L, Zhang YJ, Pan K, Pan QZ, Chen CL, Zhao JJ, Zhang XF, Zhang HX, Tang Y, Zhou ZQ, Chen MS, Xia JC - J Cancer (2016)

Bottom Line: We found that HDL-C ≤ 0.88 mmol/L and cholesterol ≤ 4.420 mmol/L were preoperative risk factors of disease-free survival (DFS) and overall survival (OS).A decreased CHO level was significantly associated with decreased OS (HR, 0.800; 95% CI, (0.691-0.926), P =0.003) and decreased DFS (HR, 0.844; 95% CI, 0.737-0.966, P=0.012).In the univariate and multivariate analyses involving OS and DFS, no significant relativity were observed between the LDL-C and TG groups.

View Article: PubMed Central - PubMed

Affiliation: 1. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China;

ABSTRACT

Purpose: To evaluate the prognostic role of the preoperative plasma lipid profile, including low-density lipoprotein -cholesterol [LDL-C], high-density lipoprotein-cholesterol [HDL-C], cholesterol, and triglycerides, in hepatocellular carcinoma patients undergoing radical resection.

Methods: Clinical data, including the preoperative plasma profile levels, were retrospectively collected and reviewed in 1411 hepatocellular carcinoma patients, who underwent operation between 2001 and 2010. Kaplan-Meier method and the Cox proportional hazards regression model were used in analyzing the DFS and OS.

Results: We found that HDL-C ≤ 0.88 mmol/L and cholesterol ≤ 4.420 mmol/L were preoperative risk factors of disease-free survival (DFS) and overall survival (OS). A decreased CHO level was significantly associated with decreased OS (HR, 0.800; 95% CI, (0.691-0.926), P =0.003) and decreased DFS (HR, 0.844; 95% CI, 0.737-0.966, P=0.012). Additionally, an increased HDL-C level was shown significant association with increased OS (HR, 0.679; 95% CI, 0.570-0.808, P<0.01) and DFS (HR, 2.085; 95% CI, 1.271- 3.422, P = 0.002). In the univariate and multivariate analyses involving OS and DFS, no significant relativity were observed between the LDL-C and TG groups.

Conclusions: Decreased levels of CHO and HDL might predict worse outcomes both DFS and OS for hepatocellular carcinoma patients.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier curve for overall survival regarding low vs high HDL-C levels (P <0.01).
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Figure 3: Kaplan-Meier curve for overall survival regarding low vs high HDL-C levels (P <0.01).

Mentions: Local recurrence or distant metastasis after radical surgical resection was confirmed in 176 of 256 (68.7%) patients with an HDL-C level ≤0.88 mmol/L and in 714 of 1155 (61.8%) patients with an HDL-C level > 0.88 mmol/L (P=0.002). Regarding OS, there were 161 of 256 (62.9%) patients with an HDL-C level ≤ 0.88 mmol/L, and 588 of 1155 (53.1%) patients with HDL-C levels > 0.88 mmol/L (P<0.01) who occurred death. In univariate analysis, a decreased HDL-C level was significantly associated with decreased OS (HR, 0.679; 95% CI, 0.570-0.808, P<0.01; Table 4; Figure 3) and remained statistically different in the multivariate analysis that included tumor size, AFP, tumor differentiation, and TNM stage (HR, 0.790; 95% CI, 0.658-0.948, P =0.011; Table 4). Patients with HDL-C levels ≤ 0.88 mmol/L had a median OS of 31 months. In contrast, patients with HDL-C levels > 0.88 mmol/L had a median OS of 61 months. In the univariate analysis, an increased HDL-C level was statistically linked with increased DFS (HR, 2.085; 95% CI, 1.271-3.422, P = 0.002; Table 5; Figure 4). However, in the multivariate analysis, HDL levels were not statistically significant (Table 5). Patients with HDL-C levels ≤ 0.88 mmol/L presented with a median DFS of 15 months, whereas patients with HDL-C levels > 0.88 mmol/L had a median DFS of 26 months.


The clinical significance of preoperative serum cholesterol and high-density lipoprotein-cholesterol levels in hepatocellular carcinoma.

Jiang SS, Weng DS, Jiang L, Zhang YJ, Pan K, Pan QZ, Chen CL, Zhao JJ, Zhang XF, Zhang HX, Tang Y, Zhou ZQ, Chen MS, Xia JC - J Cancer (2016)

Kaplan-Meier curve for overall survival regarding low vs high HDL-C levels (P <0.01).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4829548&req=5

Figure 3: Kaplan-Meier curve for overall survival regarding low vs high HDL-C levels (P <0.01).
Mentions: Local recurrence or distant metastasis after radical surgical resection was confirmed in 176 of 256 (68.7%) patients with an HDL-C level ≤0.88 mmol/L and in 714 of 1155 (61.8%) patients with an HDL-C level > 0.88 mmol/L (P=0.002). Regarding OS, there were 161 of 256 (62.9%) patients with an HDL-C level ≤ 0.88 mmol/L, and 588 of 1155 (53.1%) patients with HDL-C levels > 0.88 mmol/L (P<0.01) who occurred death. In univariate analysis, a decreased HDL-C level was significantly associated with decreased OS (HR, 0.679; 95% CI, 0.570-0.808, P<0.01; Table 4; Figure 3) and remained statistically different in the multivariate analysis that included tumor size, AFP, tumor differentiation, and TNM stage (HR, 0.790; 95% CI, 0.658-0.948, P =0.011; Table 4). Patients with HDL-C levels ≤ 0.88 mmol/L had a median OS of 31 months. In contrast, patients with HDL-C levels > 0.88 mmol/L had a median OS of 61 months. In the univariate analysis, an increased HDL-C level was statistically linked with increased DFS (HR, 2.085; 95% CI, 1.271-3.422, P = 0.002; Table 5; Figure 4). However, in the multivariate analysis, HDL levels were not statistically significant (Table 5). Patients with HDL-C levels ≤ 0.88 mmol/L presented with a median DFS of 15 months, whereas patients with HDL-C levels > 0.88 mmol/L had a median DFS of 26 months.

Bottom Line: We found that HDL-C ≤ 0.88 mmol/L and cholesterol ≤ 4.420 mmol/L were preoperative risk factors of disease-free survival (DFS) and overall survival (OS).A decreased CHO level was significantly associated with decreased OS (HR, 0.800; 95% CI, (0.691-0.926), P =0.003) and decreased DFS (HR, 0.844; 95% CI, 0.737-0.966, P=0.012).In the univariate and multivariate analyses involving OS and DFS, no significant relativity were observed between the LDL-C and TG groups.

View Article: PubMed Central - PubMed

Affiliation: 1. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China;

ABSTRACT

Purpose: To evaluate the prognostic role of the preoperative plasma lipid profile, including low-density lipoprotein -cholesterol [LDL-C], high-density lipoprotein-cholesterol [HDL-C], cholesterol, and triglycerides, in hepatocellular carcinoma patients undergoing radical resection.

Methods: Clinical data, including the preoperative plasma profile levels, were retrospectively collected and reviewed in 1411 hepatocellular carcinoma patients, who underwent operation between 2001 and 2010. Kaplan-Meier method and the Cox proportional hazards regression model were used in analyzing the DFS and OS.

Results: We found that HDL-C ≤ 0.88 mmol/L and cholesterol ≤ 4.420 mmol/L were preoperative risk factors of disease-free survival (DFS) and overall survival (OS). A decreased CHO level was significantly associated with decreased OS (HR, 0.800; 95% CI, (0.691-0.926), P =0.003) and decreased DFS (HR, 0.844; 95% CI, 0.737-0.966, P=0.012). Additionally, an increased HDL-C level was shown significant association with increased OS (HR, 0.679; 95% CI, 0.570-0.808, P<0.01) and DFS (HR, 2.085; 95% CI, 1.271- 3.422, P = 0.002). In the univariate and multivariate analyses involving OS and DFS, no significant relativity were observed between the LDL-C and TG groups.

Conclusions: Decreased levels of CHO and HDL might predict worse outcomes both DFS and OS for hepatocellular carcinoma patients.

No MeSH data available.


Related in: MedlinePlus