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Canine IgA nephropathy: a case report.

Yabuki A, Shimokawa Miyama T, Kohyama M, Yamato O - J. Vet. Med. Sci. (2015)

Bottom Line: A renal biopsy demonstrated mesangial proliferative glomerulonephritis with predominantly mesangial IgA deposition and electron-dense deposits in the paramesangium.Glucocorticoid treatment was discontinued, and the angiotensin-converting enzyme inhibitor enalapril was administrated as an antiproteinuric agent.The proteinuria subsequently went into remission, and the patient has maintained good condition without recurrence.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-8580, Japan.

ABSTRACT
Immunoglobulin (Ig) A nephropathy is a rare form of canine glomerular disease. This report describes a case of canine IgA nephropathy showing characteristics typical of human IgA nephropathy. An 8-year-old, spayed female Miniature Dachshund showed persistent severe proteinuria without azotemia. She was receiving long-term glucocorticoid therapy due to chronic gastritis and an intra-abdominal suture granuloma. A renal biopsy demonstrated mesangial proliferative glomerulonephritis with predominantly mesangial IgA deposition and electron-dense deposits in the paramesangium. These findings closely resembled those of human IgA nephropathy. Glucocorticoid treatment was discontinued, and the angiotensin-converting enzyme inhibitor enalapril was administrated as an antiproteinuric agent. The proteinuria subsequently went into remission, and the patient has maintained good condition without recurrence.

No MeSH data available.


Related in: MedlinePlus

Clinical course of the case. UP/C, urinary protein/creatinine ratio (solid line);pCre, plasma creatinine concentration (dotted line); SBP, systolic blood pressure(mmHg). SBP was measured at 0, 53 and 151 days after presentation.
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fig_004: Clinical course of the case. UP/C, urinary protein/creatinine ratio (solid line);pCre, plasma creatinine concentration (dotted line); SBP, systolic blood pressure(mmHg). SBP was measured at 0, 53 and 151 days after presentation.

Mentions: Glucocorticoids are commonly used to treat human GD, including IgA nephropathy. However, indogs, glucocorticoid therapy for GD should be tailored to the conditions and underlyingdiseases of each case [8]. Although azotemia andworsened proteinuria are known risks of glucocorticoid therapy [2, 11], use of glucocorticoids might beappropriate if the case was fulminant or featured multisystem immune-mediated disease. In thepresent case, glucocorticoid therapy was not indicated. The prednisolone treatment alreadybeing administered to treat intra-abdominal suture granuloma was therefore graduallydiscontinued while monitoring the condition of the dog, and no exacerbation of granuloma wasobserved after withdrawal. Angiotensin-converting enzyme inhibitors (ACEI) have well knownbeneficial effects in human proteinuric GD, including IgA nephropathy [10], and are a standard therapy in canine proteinuric GD [7]. In the present case, enalapril (Enacard, Merial Japan,Tokyo; 0.4 mg/kg, once daily, oral) was administrated as an antiproteinuric agent. Theproteinuria subsequently resolved, and the UP/C gradually decreased to 0.71, 0.34 and 0.06 at53, 60 and 151 days after presentation, respectively (Fig. 4Fig. 4.


Canine IgA nephropathy: a case report.

Yabuki A, Shimokawa Miyama T, Kohyama M, Yamato O - J. Vet. Med. Sci. (2015)

Clinical course of the case. UP/C, urinary protein/creatinine ratio (solid line);pCre, plasma creatinine concentration (dotted line); SBP, systolic blood pressure(mmHg). SBP was measured at 0, 53 and 151 days after presentation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4829528&req=5

fig_004: Clinical course of the case. UP/C, urinary protein/creatinine ratio (solid line);pCre, plasma creatinine concentration (dotted line); SBP, systolic blood pressure(mmHg). SBP was measured at 0, 53 and 151 days after presentation.
Mentions: Glucocorticoids are commonly used to treat human GD, including IgA nephropathy. However, indogs, glucocorticoid therapy for GD should be tailored to the conditions and underlyingdiseases of each case [8]. Although azotemia andworsened proteinuria are known risks of glucocorticoid therapy [2, 11], use of glucocorticoids might beappropriate if the case was fulminant or featured multisystem immune-mediated disease. In thepresent case, glucocorticoid therapy was not indicated. The prednisolone treatment alreadybeing administered to treat intra-abdominal suture granuloma was therefore graduallydiscontinued while monitoring the condition of the dog, and no exacerbation of granuloma wasobserved after withdrawal. Angiotensin-converting enzyme inhibitors (ACEI) have well knownbeneficial effects in human proteinuric GD, including IgA nephropathy [10], and are a standard therapy in canine proteinuric GD [7]. In the present case, enalapril (Enacard, Merial Japan,Tokyo; 0.4 mg/kg, once daily, oral) was administrated as an antiproteinuric agent. Theproteinuria subsequently resolved, and the UP/C gradually decreased to 0.71, 0.34 and 0.06 at53, 60 and 151 days after presentation, respectively (Fig. 4Fig. 4.

Bottom Line: A renal biopsy demonstrated mesangial proliferative glomerulonephritis with predominantly mesangial IgA deposition and electron-dense deposits in the paramesangium.Glucocorticoid treatment was discontinued, and the angiotensin-converting enzyme inhibitor enalapril was administrated as an antiproteinuric agent.The proteinuria subsequently went into remission, and the patient has maintained good condition without recurrence.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-8580, Japan.

ABSTRACT
Immunoglobulin (Ig) A nephropathy is a rare form of canine glomerular disease. This report describes a case of canine IgA nephropathy showing characteristics typical of human IgA nephropathy. An 8-year-old, spayed female Miniature Dachshund showed persistent severe proteinuria without azotemia. She was receiving long-term glucocorticoid therapy due to chronic gastritis and an intra-abdominal suture granuloma. A renal biopsy demonstrated mesangial proliferative glomerulonephritis with predominantly mesangial IgA deposition and electron-dense deposits in the paramesangium. These findings closely resembled those of human IgA nephropathy. Glucocorticoid treatment was discontinued, and the angiotensin-converting enzyme inhibitor enalapril was administrated as an antiproteinuric agent. The proteinuria subsequently went into remission, and the patient has maintained good condition without recurrence.

No MeSH data available.


Related in: MedlinePlus