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Canine pyometra: a model for the analysis of serum CXCL8 in inflammation.

Haas M, Kaup FJ, Neumann S - J. Vet. Med. Sci. (2015)

Bottom Line: Thus, we used naturally occurring canine pyometra as a model of inflammation, in order to examine the behavior of serum CXCL8 in relation to the disease intensity and commonly analyzed inflammatory mediators.Interestingly, serum CXCL8 did not increase in severely diseased patients and behaved contrary to white blood cells (WBC), neutrophils and C-reactive protein (CRP).The measurement of serum CXCL8 may provide valuable information about the extent of ongoing lesions and could be a useful complement for existing laboratory tests.

View Article: PubMed Central - PubMed

Affiliation: Institute of Veterinary Medicine, Georg August University of Göttingen, Burckhardtweg 2, D-37077 Göttingen, Germany.

ABSTRACT
Interleukin-8 (IL-8 or CXCL8) is a highly selective pro-inflammatory chemokine, that is elevated in sera of humans and animals with various inflammatory diseases. CXCL8 is possibly involved in uncontrolled inflammation and the development of a systemic inflammatory response syndrome (SIRS) and sepsis. Nevertheless, its behavior and precise properties in the course of inflammation are not fully understood. Thus, we used naturally occurring canine pyometra as a model of inflammation, in order to examine the behavior of serum CXCL8 in relation to the disease intensity and commonly analyzed inflammatory mediators. Using a commercially available canine ELISA kit, a significant increase of CXCL8 was determined in the serum of 23 dogs with pyometra compared with 35 healthy dogs. Interestingly, serum CXCL8 did not increase in severely diseased patients and behaved contrary to white blood cells (WBC), neutrophils and C-reactive protein (CRP). The measurement of serum CXCL8 may provide valuable information about the extent of ongoing lesions and could be a useful complement for existing laboratory tests.

No MeSH data available.


Related in: MedlinePlus

Serum CXCL8 has an opposed behavior to that of neutrophils and CRP. a) Normalizedvalues of serum CXCL8, neutrophils and CRP in each patient. b) Normalized values ofserum CXCL8, neutrophils and CRP in relationship to the symptoms intensity. c)Normalized values of serum CXCL8, neutrophils and CRP in relationship and CRP in therelationship to the uterine distension.
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fig_003: Serum CXCL8 has an opposed behavior to that of neutrophils and CRP. a) Normalizedvalues of serum CXCL8, neutrophils and CRP in each patient. b) Normalized values ofserum CXCL8, neutrophils and CRP in relationship to the symptoms intensity. c)Normalized values of serum CXCL8, neutrophils and CRP in relationship and CRP in therelationship to the uterine distension.

Mentions: A graphical representation of the CXCL8, neutrophil count and CRP values, and theirassociation to the symptomatology and the uterine distension remarked the opposed behaviorof these inflammatory mediators (Fig. 3Fig. 3.


Canine pyometra: a model for the analysis of serum CXCL8 in inflammation.

Haas M, Kaup FJ, Neumann S - J. Vet. Med. Sci. (2015)

Serum CXCL8 has an opposed behavior to that of neutrophils and CRP. a) Normalizedvalues of serum CXCL8, neutrophils and CRP in each patient. b) Normalized values ofserum CXCL8, neutrophils and CRP in relationship to the symptoms intensity. c)Normalized values of serum CXCL8, neutrophils and CRP in relationship and CRP in therelationship to the uterine distension.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4829503&req=5

fig_003: Serum CXCL8 has an opposed behavior to that of neutrophils and CRP. a) Normalizedvalues of serum CXCL8, neutrophils and CRP in each patient. b) Normalized values ofserum CXCL8, neutrophils and CRP in relationship to the symptoms intensity. c)Normalized values of serum CXCL8, neutrophils and CRP in relationship and CRP in therelationship to the uterine distension.
Mentions: A graphical representation of the CXCL8, neutrophil count and CRP values, and theirassociation to the symptomatology and the uterine distension remarked the opposed behaviorof these inflammatory mediators (Fig. 3Fig. 3.

Bottom Line: Thus, we used naturally occurring canine pyometra as a model of inflammation, in order to examine the behavior of serum CXCL8 in relation to the disease intensity and commonly analyzed inflammatory mediators.Interestingly, serum CXCL8 did not increase in severely diseased patients and behaved contrary to white blood cells (WBC), neutrophils and C-reactive protein (CRP).The measurement of serum CXCL8 may provide valuable information about the extent of ongoing lesions and could be a useful complement for existing laboratory tests.

View Article: PubMed Central - PubMed

Affiliation: Institute of Veterinary Medicine, Georg August University of Göttingen, Burckhardtweg 2, D-37077 Göttingen, Germany.

ABSTRACT
Interleukin-8 (IL-8 or CXCL8) is a highly selective pro-inflammatory chemokine, that is elevated in sera of humans and animals with various inflammatory diseases. CXCL8 is possibly involved in uncontrolled inflammation and the development of a systemic inflammatory response syndrome (SIRS) and sepsis. Nevertheless, its behavior and precise properties in the course of inflammation are not fully understood. Thus, we used naturally occurring canine pyometra as a model of inflammation, in order to examine the behavior of serum CXCL8 in relation to the disease intensity and commonly analyzed inflammatory mediators. Using a commercially available canine ELISA kit, a significant increase of CXCL8 was determined in the serum of 23 dogs with pyometra compared with 35 healthy dogs. Interestingly, serum CXCL8 did not increase in severely diseased patients and behaved contrary to white blood cells (WBC), neutrophils and C-reactive protein (CRP). The measurement of serum CXCL8 may provide valuable information about the extent of ongoing lesions and could be a useful complement for existing laboratory tests.

No MeSH data available.


Related in: MedlinePlus