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Inverted Sinonasal Papilloma Masquerading as a Malignancy - Report of an Unusual Case.

Prasad H, Sruthi R, Anuthama K, Perumal M, Parthasarathy R - Cureus (2016)

Bottom Line: On histopathological examination of the excised specimen, a diagnosis of ISP was arrived at.However, an extensive sampling of the tissue revealed no evidence of any malignant transformation.Considering the alarming clinical course in spite of its benign nature, it is important for the pathologist and surgeon to be well informed about this lesion.

View Article: PubMed Central - HTML - PubMed

Affiliation: Oral and Maxillofacial Pathology and Microbiology, KSR Institute of Dental Science and Research.

ABSTRACT
Inverted sinonasal papilloma (ISP) is a benign epithelial neoplasm arising from the Schneiderian membrane. We report a case of ISP in a 50-year-old male that clinically presented as a polypoid mass in the nasal cavity. Imaging studies revealed it to be an aggressive lesion showing intracranial extension. On histopathological examination of the excised specimen, a diagnosis of ISP was arrived at. However, an extensive sampling of the tissue revealed no evidence of any malignant transformation. Taking into account the suggested viral aetiology for such lesions and the aggressiveness observed in this case, human papillomavirus (HPV) profiling was done but it turned out to be negative. Only one other case of inverted sinonasal papilloma arising from the nasal cavity and involving the brain has been reported in the literature to date. Considering the alarming clinical course in spite of its benign nature, it is important for the pathologist and surgeon to be well informed about this lesion.

No MeSH data available.


Related in: MedlinePlus

Polypoid mass seen filling the left nasal cavity
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FIG1: Polypoid mass seen filling the left nasal cavity

Mentions: A 50-year-old male patient presented with complaints of nasal stuffiness and bilateral purulent blood-tinged nasal discharge of eight years duration. He experienced vomiting, occasional loss of consciousness, anosmia, and headache for the last one month. The patient also gave a history of undergoing an operative procedure for removal of a nasal growth 10 years ago. He had been under Siddha treatment (traditional Indian medicine) for the same problem since that time. On physical examination, a diffuse swelling was seen on the left side of the nose, obliterating the nasal fold and causing flaring of the left ala. A reddish pink polypoid mass partially filling the left nasal cavity, with associated purulent bloody discharge, was noticed (Figure 1). On palpation, it was friable, tender, and readily bled on provocation. Informed patient consent was obtained for treatment. No reference to the patient's identity is present in this paper.


Inverted Sinonasal Papilloma Masquerading as a Malignancy - Report of an Unusual Case.

Prasad H, Sruthi R, Anuthama K, Perumal M, Parthasarathy R - Cureus (2016)

Polypoid mass seen filling the left nasal cavity
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4829412&req=5

FIG1: Polypoid mass seen filling the left nasal cavity
Mentions: A 50-year-old male patient presented with complaints of nasal stuffiness and bilateral purulent blood-tinged nasal discharge of eight years duration. He experienced vomiting, occasional loss of consciousness, anosmia, and headache for the last one month. The patient also gave a history of undergoing an operative procedure for removal of a nasal growth 10 years ago. He had been under Siddha treatment (traditional Indian medicine) for the same problem since that time. On physical examination, a diffuse swelling was seen on the left side of the nose, obliterating the nasal fold and causing flaring of the left ala. A reddish pink polypoid mass partially filling the left nasal cavity, with associated purulent bloody discharge, was noticed (Figure 1). On palpation, it was friable, tender, and readily bled on provocation. Informed patient consent was obtained for treatment. No reference to the patient's identity is present in this paper.

Bottom Line: On histopathological examination of the excised specimen, a diagnosis of ISP was arrived at.However, an extensive sampling of the tissue revealed no evidence of any malignant transformation.Considering the alarming clinical course in spite of its benign nature, it is important for the pathologist and surgeon to be well informed about this lesion.

View Article: PubMed Central - HTML - PubMed

Affiliation: Oral and Maxillofacial Pathology and Microbiology, KSR Institute of Dental Science and Research.

ABSTRACT
Inverted sinonasal papilloma (ISP) is a benign epithelial neoplasm arising from the Schneiderian membrane. We report a case of ISP in a 50-year-old male that clinically presented as a polypoid mass in the nasal cavity. Imaging studies revealed it to be an aggressive lesion showing intracranial extension. On histopathological examination of the excised specimen, a diagnosis of ISP was arrived at. However, an extensive sampling of the tissue revealed no evidence of any malignant transformation. Taking into account the suggested viral aetiology for such lesions and the aggressiveness observed in this case, human papillomavirus (HPV) profiling was done but it turned out to be negative. Only one other case of inverted sinonasal papilloma arising from the nasal cavity and involving the brain has been reported in the literature to date. Considering the alarming clinical course in spite of its benign nature, it is important for the pathologist and surgeon to be well informed about this lesion.

No MeSH data available.


Related in: MedlinePlus