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Relationship between Serum Ferritin Levels and Dyslipidemia in Korean Adolescents.

Kim YE, Kim DH, Roh YK, Ju SY, Yoon YJ, Nam GE, Nam HY, Choi JS, Lee JE, Sang JE, Han K, Park YG - PLoS ONE (2016)

Bottom Line: We analyzed 1,879 subjects (1,026 boys and 853 girls) from the 2009-2010 Korean National Health and Nutrition Examination Survey IV.Subjects were categorized into quartiles according to their lipid parameters, which were classified according to age and gender.In both boys and girls, serum ferritin levels were negatively associated with HDL-C values, even after adjusting for all covariates.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, Korea University, College of Medicine, Seoul, Republic of Korea.

ABSTRACT

Background: Ferritin is associated with various cardiometabolic risk factors such as dyslipidemia, hypertension, obesity, and insulin resistance in adults. We aimed to study the association between serum ferritin levels and dyslipidemia in adolescents, because dyslipidemia is considered an important modifiable cardiovascular risk factor in the young.

Methods: We analyzed 1,879 subjects (1,026 boys and 853 girls) from the 2009-2010 Korean National Health and Nutrition Examination Survey IV. Subjects were categorized into quartiles according to their lipid parameters, which were classified according to age and gender. Those in the highest quartile groups for total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride concentrations were diagnosed as having dyslipidemia. Those in the lowest quartile for high-density lipoprotein cholesterol (HDL-C) values were diagnosed with abnormal levels.

Results: In boys, total cholesterol, LDL-C, and triglyceride concentrations were significantly correlated with serum ferritin levels. In both boys and girls, serum ferritin levels were negatively associated with HDL-C values, even after adjusting for all covariates. Furthermore, there was no significant correlation between serum ferritin levels and total cholesterol, LDL, and triglyceride concentrations in girls.

Conclusion: Serum ferritin levels were significantly associated with major dyslipidemia parameters, more prominently in boys than in girls, and this association represents a cardiometabolic risk factor.

No MeSH data available.


Related in: MedlinePlus

Analysis of covariance of serum ferritin levels according to the number of satisfied dyslipidemia variables in age-, height-, weight-, place-, smoking status-, drinking-, physical activity-, serum 25(OH)D levels-, total daily energy intake-, fat-, protein-, calcium intakes; and menarche in girls-adjusted model (boys, P < 0.001; girls, P = 0.06).
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pone.0153167.g003: Analysis of covariance of serum ferritin levels according to the number of satisfied dyslipidemia variables in age-, height-, weight-, place-, smoking status-, drinking-, physical activity-, serum 25(OH)D levels-, total daily energy intake-, fat-, protein-, calcium intakes; and menarche in girls-adjusted model (boys, P < 0.001; girls, P = 0.06).

Mentions: Fig 3 shows the trend in serum ferritin levels according to the number of satisfied dyslipidemic parameters, which were estimated by ANCOVA after adjustments for age, height, weight, place, smoking status, drinking, physical activity, serum 25(OH)D levels, total daily energy intake, fat, protein, calcium intakes and menarche in girls. The mean serum ferritin levels significantly increased as the number of satisfied dyslipidemic parameters accumulated in both genders (boys, P < 0.001; girls, P < 0.06).


Relationship between Serum Ferritin Levels and Dyslipidemia in Korean Adolescents.

Kim YE, Kim DH, Roh YK, Ju SY, Yoon YJ, Nam GE, Nam HY, Choi JS, Lee JE, Sang JE, Han K, Park YG - PLoS ONE (2016)

Analysis of covariance of serum ferritin levels according to the number of satisfied dyslipidemia variables in age-, height-, weight-, place-, smoking status-, drinking-, physical activity-, serum 25(OH)D levels-, total daily energy intake-, fat-, protein-, calcium intakes; and menarche in girls-adjusted model (boys, P < 0.001; girls, P = 0.06).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4829261&req=5

pone.0153167.g003: Analysis of covariance of serum ferritin levels according to the number of satisfied dyslipidemia variables in age-, height-, weight-, place-, smoking status-, drinking-, physical activity-, serum 25(OH)D levels-, total daily energy intake-, fat-, protein-, calcium intakes; and menarche in girls-adjusted model (boys, P < 0.001; girls, P = 0.06).
Mentions: Fig 3 shows the trend in serum ferritin levels according to the number of satisfied dyslipidemic parameters, which were estimated by ANCOVA after adjustments for age, height, weight, place, smoking status, drinking, physical activity, serum 25(OH)D levels, total daily energy intake, fat, protein, calcium intakes and menarche in girls. The mean serum ferritin levels significantly increased as the number of satisfied dyslipidemic parameters accumulated in both genders (boys, P < 0.001; girls, P < 0.06).

Bottom Line: We analyzed 1,879 subjects (1,026 boys and 853 girls) from the 2009-2010 Korean National Health and Nutrition Examination Survey IV.Subjects were categorized into quartiles according to their lipid parameters, which were classified according to age and gender.In both boys and girls, serum ferritin levels were negatively associated with HDL-C values, even after adjusting for all covariates.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, Korea University, College of Medicine, Seoul, Republic of Korea.

ABSTRACT

Background: Ferritin is associated with various cardiometabolic risk factors such as dyslipidemia, hypertension, obesity, and insulin resistance in adults. We aimed to study the association between serum ferritin levels and dyslipidemia in adolescents, because dyslipidemia is considered an important modifiable cardiovascular risk factor in the young.

Methods: We analyzed 1,879 subjects (1,026 boys and 853 girls) from the 2009-2010 Korean National Health and Nutrition Examination Survey IV. Subjects were categorized into quartiles according to their lipid parameters, which were classified according to age and gender. Those in the highest quartile groups for total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride concentrations were diagnosed as having dyslipidemia. Those in the lowest quartile for high-density lipoprotein cholesterol (HDL-C) values were diagnosed with abnormal levels.

Results: In boys, total cholesterol, LDL-C, and triglyceride concentrations were significantly correlated with serum ferritin levels. In both boys and girls, serum ferritin levels were negatively associated with HDL-C values, even after adjusting for all covariates. Furthermore, there was no significant correlation between serum ferritin levels and total cholesterol, LDL, and triglyceride concentrations in girls.

Conclusion: Serum ferritin levels were significantly associated with major dyslipidemia parameters, more prominently in boys than in girls, and this association represents a cardiometabolic risk factor.

No MeSH data available.


Related in: MedlinePlus