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The Extrastriate Body Area Computes Desired Goal States during Action Planning.

Zimmermann M, Verhagen L, de Lange FP, Toni I - eNeuro (2016)

Bottom Line: Second, the contributions of EBA are earlier in time than those of a caudal intraparietal region known to specify the action plan.Third, the contributions of EBA are particularly important when desired and current object configurations differ, and multiple courses of actions are possible.These findings specify the temporal and functional characteristics for a mechanism that integrates perceptual processing with motor planning.

View Article: PubMed Central - HTML - PubMed

Affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands; Department of Women's and Children's Health, Karolinska Institute, 17177 Stockholm, Sweden.

ABSTRACT
How do object perception and action interact at a neural level? Here we test the hypothesis that perceptual features, processed by the ventral visuoperceptual stream, are used as priors by the dorsal visuomotor stream to specify goal-directed grasping actions. We present three main findings, which were obtained by combining time-resolved transcranial magnetic stimulation and kinematic tracking of grasp-and-rotate object manipulations, in a group of healthy human participants (N = 22). First, the extrastriate body area (EBA), in the ventral stream, provides an initial structure to motor plans, based on current and desired states of a grasped object and of the grasping hand. Second, the contributions of EBA are earlier in time than those of a caudal intraparietal region known to specify the action plan. Third, the contributions of EBA are particularly important when desired and current object configurations differ, and multiple courses of actions are possible. These findings specify the temporal and functional characteristics for a mechanism that integrates perceptual processing with motor planning.

No MeSH data available.


Related in: MedlinePlus

Time-resolved analysis of TMS effects on goal-state error. Top, Temporal dynamics of effects of TMS over EBA (blue) and IPS (orange) on goal-state error, time locked to trial onset (left) and wrist movement onset (right) for MULTIPLE-option ROTATE actions. Bold line sections indicate temporal clusters in which TMS over EBA/IPS had a significantly larger effect than sham stimulation at the same time. Abrupt transitions between datapoints of the time-resolved average are a consequence of the different number of participants contributing to different datapoints. Wrist movement onset refers to the earliest detectable sign of arm motion, namely, changes in wrist position (measured with a motion-tracking system) that occurred systematically earlier than the release of the home button. There were no TMS pulses delivered after participants released the home button. Bottom, Distribution of button press times and wrist movement-onset times (left) or trial-onset times (right) relative to TMS time in the corresponding top panel.
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Figure 5: Time-resolved analysis of TMS effects on goal-state error. Top, Temporal dynamics of effects of TMS over EBA (blue) and IPS (orange) on goal-state error, time locked to trial onset (left) and wrist movement onset (right) for MULTIPLE-option ROTATE actions. Bold line sections indicate temporal clusters in which TMS over EBA/IPS had a significantly larger effect than sham stimulation at the same time. Abrupt transitions between datapoints of the time-resolved average are a consequence of the different number of participants contributing to different datapoints. Wrist movement onset refers to the earliest detectable sign of arm motion, namely, changes in wrist position (measured with a motion-tracking system) that occurred systematically earlier than the release of the home button. There were no TMS pulses delivered after participants released the home button. Bottom, Distribution of button press times and wrist movement-onset times (left) or trial-onset times (right) relative to TMS time in the corresponding top panel.

Mentions: A post hoc exploration of the temporal dynamics of the effect of tms-time on goal-state error during multiple-option rotation trials assessed how this parameter changed as a function of the timing of the TMS intervention, relative to trial onset and movement onset. For every level of tms-site, a moving Hanning weighting window (width, 150 ms) was used to average goal-state errors over trials with similar relative TMS latencies. Subsequently, for every time point (bin size, 1 ms) these “time courses” for the stimulation of EBA and IPS were compared with the stimulation of SHAM using paired t tests with an α level of p < 0.05. Cluster-based permutation tests were performed in FieldTrip (Oostenveld et al., 2011) to correct for multiple comparisons, where applicable (i.e., not possible for movement-locked analyses due to changing numbers of participants contributing to different time points). When TMS intervention was time locked to trial onset (Fig. 5, left), the stimulation of EBA resulted in a significant cluster between 152 and 228 ms after trial onset compared with SHAM stimulation (p = 0.046). When time locked to wrist movement onset (Fig. 5, right), the stimulation of IPS from 48 ms after wrist movement onset onward (but before button release) resulted in significantly larger errors compared with SHAM stimulation.


The Extrastriate Body Area Computes Desired Goal States during Action Planning.

Zimmermann M, Verhagen L, de Lange FP, Toni I - eNeuro (2016)

Time-resolved analysis of TMS effects on goal-state error. Top, Temporal dynamics of effects of TMS over EBA (blue) and IPS (orange) on goal-state error, time locked to trial onset (left) and wrist movement onset (right) for MULTIPLE-option ROTATE actions. Bold line sections indicate temporal clusters in which TMS over EBA/IPS had a significantly larger effect than sham stimulation at the same time. Abrupt transitions between datapoints of the time-resolved average are a consequence of the different number of participants contributing to different datapoints. Wrist movement onset refers to the earliest detectable sign of arm motion, namely, changes in wrist position (measured with a motion-tracking system) that occurred systematically earlier than the release of the home button. There were no TMS pulses delivered after participants released the home button. Bottom, Distribution of button press times and wrist movement-onset times (left) or trial-onset times (right) relative to TMS time in the corresponding top panel.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4821904&req=5

Figure 5: Time-resolved analysis of TMS effects on goal-state error. Top, Temporal dynamics of effects of TMS over EBA (blue) and IPS (orange) on goal-state error, time locked to trial onset (left) and wrist movement onset (right) for MULTIPLE-option ROTATE actions. Bold line sections indicate temporal clusters in which TMS over EBA/IPS had a significantly larger effect than sham stimulation at the same time. Abrupt transitions between datapoints of the time-resolved average are a consequence of the different number of participants contributing to different datapoints. Wrist movement onset refers to the earliest detectable sign of arm motion, namely, changes in wrist position (measured with a motion-tracking system) that occurred systematically earlier than the release of the home button. There were no TMS pulses delivered after participants released the home button. Bottom, Distribution of button press times and wrist movement-onset times (left) or trial-onset times (right) relative to TMS time in the corresponding top panel.
Mentions: A post hoc exploration of the temporal dynamics of the effect of tms-time on goal-state error during multiple-option rotation trials assessed how this parameter changed as a function of the timing of the TMS intervention, relative to trial onset and movement onset. For every level of tms-site, a moving Hanning weighting window (width, 150 ms) was used to average goal-state errors over trials with similar relative TMS latencies. Subsequently, for every time point (bin size, 1 ms) these “time courses” for the stimulation of EBA and IPS were compared with the stimulation of SHAM using paired t tests with an α level of p < 0.05. Cluster-based permutation tests were performed in FieldTrip (Oostenveld et al., 2011) to correct for multiple comparisons, where applicable (i.e., not possible for movement-locked analyses due to changing numbers of participants contributing to different time points). When TMS intervention was time locked to trial onset (Fig. 5, left), the stimulation of EBA resulted in a significant cluster between 152 and 228 ms after trial onset compared with SHAM stimulation (p = 0.046). When time locked to wrist movement onset (Fig. 5, right), the stimulation of IPS from 48 ms after wrist movement onset onward (but before button release) resulted in significantly larger errors compared with SHAM stimulation.

Bottom Line: Second, the contributions of EBA are earlier in time than those of a caudal intraparietal region known to specify the action plan.Third, the contributions of EBA are particularly important when desired and current object configurations differ, and multiple courses of actions are possible.These findings specify the temporal and functional characteristics for a mechanism that integrates perceptual processing with motor planning.

View Article: PubMed Central - HTML - PubMed

Affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands; Department of Women's and Children's Health, Karolinska Institute, 17177 Stockholm, Sweden.

ABSTRACT
How do object perception and action interact at a neural level? Here we test the hypothesis that perceptual features, processed by the ventral visuoperceptual stream, are used as priors by the dorsal visuomotor stream to specify goal-directed grasping actions. We present three main findings, which were obtained by combining time-resolved transcranial magnetic stimulation and kinematic tracking of grasp-and-rotate object manipulations, in a group of healthy human participants (N = 22). First, the extrastriate body area (EBA), in the ventral stream, provides an initial structure to motor plans, based on current and desired states of a grasped object and of the grasping hand. Second, the contributions of EBA are earlier in time than those of a caudal intraparietal region known to specify the action plan. Third, the contributions of EBA are particularly important when desired and current object configurations differ, and multiple courses of actions are possible. These findings specify the temporal and functional characteristics for a mechanism that integrates perceptual processing with motor planning.

No MeSH data available.


Related in: MedlinePlus