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Programmed Cell Death-1 Polymorphisms Decrease the Cancer Risk: A Meta-Analysis Involving Twelve Case-Control Studies.

Dong W, Gong M, Shi Z, Xiao J, Zhang J, Peng J - PLoS ONE (2016)

Bottom Line: However, the results of the studies are conflicting.In addition, a similar result was also found in T vs.Additional epidemiological studies are needed to confirm our findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Zhongshan Affiliated Hospital of Sun Yat-sen University, Zhongshan, Guangdong 528403, China.

ABSTRACT
Programmed cell death-1 (PD-1) plays an important inhibitory role in anti-tumor responses, so it is considered as a powerful candidate gene for individual's genetic susceptibility to cancer. Recently, some epidemiological studies have evaluated the association between PD-1 polymorphisms and cancer risk. However, the results of the studies are conflicting. Therefore, a meta-analysis was performed. We identified all studies reporting the relationship between PD-1 polymorphisms and cancers by electronically searches. According to the inclusion criteria and the quality assessment of Newcastle-Ottawa Scale (NOS), only high quality studies were included. A total of twelve relevant studies involving 5,206 cases and 5,174 controls were recruited. For PD-1.5 (rs2227981) polymorphism, significantly decreased cancer risks were obtained among overall population, Asians subgroup and population-based subgroup both in TT vs. CC and TT vs. CT+CC genetic models. In addition, a similar result was also found in T vs. C allele for overall population. However, there were no significant associations between either PD-1.9 (rs2227982) or PD-1 rs7421861 polymorphisms and cancer risks in all genetic models and alleles. For PD-1.3 (rs11568821) polymorphism, we found different cancer susceptibilities between GA vs. GG and AA vs. AG+GG genetic models, and no associations between AA vs. GG, AA+AG vs. GG genetic models or A vs. G allele and cancer risks. In general, our results firstly indicated that PD-1.5 (rs2227981) polymorphism is associated a strongly decreased risk of cancers. Additional epidemiological studies are needed to confirm our findings.

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Related in: MedlinePlus

Flow diagram of study selection.
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pone.0152448.g001: Flow diagram of study selection.

Mentions: Five hundred and sixty-eight studies were retrieved after searching and screening based on our literature search strategy. There were 18 studies left when the irrelevant studies were excluded. Out of these, 14 studies had analyzed the association between the PD-1 polymorphisms and cancers. After data extraction, one article [25] was excluded because of without control group while another one [26] was excluded as discussed about the gestational trophoblastic neoplasms, which contain both benign and malignant tumors. Hence we obtained 12 relevant studies that examined the association between the PD-1 polymorphisms and cancer risk (Fig 1) [27–38]. All of them were evaluated by Newcastle-Ottawa Scale and met the high quality (Table 2). Overall, the meta-analysis included 5,206 cancer patients and 5,174 controls from 12 articles. The information extracted from all eligible articles was summarized in Table 1. All articles we included were case-control studies. Among them, breast cancer, gastric cancer, colorectal cancer and lung cancer are studied by two articles, respectively. The rest four studies are colon, esophageal, cervical and liver cancer study, respectively. Out of the 12 studies, 7 studies focused on the PD-1.5 (rs2227981), while the PD-1.9 (rs2227982), PD-1 rs7421861 and PD-1.3(rs11568821) were all discussed in 4 studies, respectively. Among the 12 studies included in the meta-analysis, there were 11 studies of Asians and 1 study of Caucasians. According to the control source, only 4 were hospital-based researches, the rest 8 were population-based researches.


Programmed Cell Death-1 Polymorphisms Decrease the Cancer Risk: A Meta-Analysis Involving Twelve Case-Control Studies.

Dong W, Gong M, Shi Z, Xiao J, Zhang J, Peng J - PLoS ONE (2016)

Flow diagram of study selection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4816386&req=5

pone.0152448.g001: Flow diagram of study selection.
Mentions: Five hundred and sixty-eight studies were retrieved after searching and screening based on our literature search strategy. There were 18 studies left when the irrelevant studies were excluded. Out of these, 14 studies had analyzed the association between the PD-1 polymorphisms and cancers. After data extraction, one article [25] was excluded because of without control group while another one [26] was excluded as discussed about the gestational trophoblastic neoplasms, which contain both benign and malignant tumors. Hence we obtained 12 relevant studies that examined the association between the PD-1 polymorphisms and cancer risk (Fig 1) [27–38]. All of them were evaluated by Newcastle-Ottawa Scale and met the high quality (Table 2). Overall, the meta-analysis included 5,206 cancer patients and 5,174 controls from 12 articles. The information extracted from all eligible articles was summarized in Table 1. All articles we included were case-control studies. Among them, breast cancer, gastric cancer, colorectal cancer and lung cancer are studied by two articles, respectively. The rest four studies are colon, esophageal, cervical and liver cancer study, respectively. Out of the 12 studies, 7 studies focused on the PD-1.5 (rs2227981), while the PD-1.9 (rs2227982), PD-1 rs7421861 and PD-1.3(rs11568821) were all discussed in 4 studies, respectively. Among the 12 studies included in the meta-analysis, there were 11 studies of Asians and 1 study of Caucasians. According to the control source, only 4 were hospital-based researches, the rest 8 were population-based researches.

Bottom Line: However, the results of the studies are conflicting.In addition, a similar result was also found in T vs.Additional epidemiological studies are needed to confirm our findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Zhongshan Affiliated Hospital of Sun Yat-sen University, Zhongshan, Guangdong 528403, China.

ABSTRACT
Programmed cell death-1 (PD-1) plays an important inhibitory role in anti-tumor responses, so it is considered as a powerful candidate gene for individual's genetic susceptibility to cancer. Recently, some epidemiological studies have evaluated the association between PD-1 polymorphisms and cancer risk. However, the results of the studies are conflicting. Therefore, a meta-analysis was performed. We identified all studies reporting the relationship between PD-1 polymorphisms and cancers by electronically searches. According to the inclusion criteria and the quality assessment of Newcastle-Ottawa Scale (NOS), only high quality studies were included. A total of twelve relevant studies involving 5,206 cases and 5,174 controls were recruited. For PD-1.5 (rs2227981) polymorphism, significantly decreased cancer risks were obtained among overall population, Asians subgroup and population-based subgroup both in TT vs. CC and TT vs. CT+CC genetic models. In addition, a similar result was also found in T vs. C allele for overall population. However, there were no significant associations between either PD-1.9 (rs2227982) or PD-1 rs7421861 polymorphisms and cancer risks in all genetic models and alleles. For PD-1.3 (rs11568821) polymorphism, we found different cancer susceptibilities between GA vs. GG and AA vs. AG+GG genetic models, and no associations between AA vs. GG, AA+AG vs. GG genetic models or A vs. G allele and cancer risks. In general, our results firstly indicated that PD-1.5 (rs2227981) polymorphism is associated a strongly decreased risk of cancers. Additional epidemiological studies are needed to confirm our findings.

Show MeSH
Related in: MedlinePlus