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Zoonotic Mycobacterium bovis-induced tuberculosis in humans.

Müller B, Dürr S, Alonso S, Hattendorf J, Laisse CJ, Parsons SD, van Helden PD, Zinsstag J - Emerging Infect. Dis. (2013)

Bottom Line: In regions outside Africa included in this study, overall median proportions of zoonotic TB of ≤1.4% in connection with overall TB incidence rates ≤71/100,000 population/year suggested low incidence rates.For countries of Africa included in the study, we multiplied the observed median proportion of zoonotic TB cases of 2.8% with the continental average overall TB incidence rate of 264/100,000 population/year, which resulted in a crude estimate of 7 zoonotic TB cases/100,000 population/year.These generally low incidence rates notwithstanding, available data indicated substantial consequences of this disease for some population groups and settings.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa. borna.mueller@gmail.com

ABSTRACT
We aimed to estimate the global occurrence of zoonotic tuberculosis (TB) caused by Mycobacterium bovis or M. caprae infections in humans by performing a multilingual, systematic review and analysis of relevant scientific literature of the last 2 decades. Although information from many parts of the world was not available, data from 61 countries suggested a low global disease incidence. In regions outside Africa included in this study, overall median proportions of zoonotic TB of ≤1.4% in connection with overall TB incidence rates ≤71/100,000 population/year suggested low incidence rates. For countries of Africa included in the study, we multiplied the observed median proportion of zoonotic TB cases of 2.8% with the continental average overall TB incidence rate of 264/100,000 population/year, which resulted in a crude estimate of 7 zoonotic TB cases/100,000 population/year. These generally low incidence rates notwithstanding, available data indicated substantial consequences of this disease for some population groups and settings.

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Selection procedure for reports included in this analysis. A list of all identified 1,203 potentially relevant reports and the core dataset is available as supplemental material (online Technical Appendix 2, wwwnc.cdc.gov/EID/article/19/6/12-0543-Techapp2.xlsx). TB, tuberculosis; M. bovis, Mycobacterium bovis.
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Figure 1: Selection procedure for reports included in this analysis. A list of all identified 1,203 potentially relevant reports and the core dataset is available as supplemental material (online Technical Appendix 2, wwwnc.cdc.gov/EID/article/19/6/12-0543-Techapp2.xlsx). TB, tuberculosis; M. bovis, Mycobacterium bovis.

Mentions: A systematic multilingual literature search was performed according to international guidelines with certain modifications (http://www.cochrane-handbook.org/). Potentially relevant reports on putative zoonotic TB caused by M. bovis or M. caprae were identified by a search of 32 bibliographic databases by using a highly sensitive search syntax. All publications/reports documented in the various databases and published until March 2010 were considered (Table 1, Technical Appendix 1, and Technical Appendix 2). Reference Manager v11.0.1 bibliographic software was used to store and remove duplicated reports, leaving 12,176 records (Figure 1). Titles and abstracts of these reports were screened to remove studies unlikely to contain pertinent information. Altogether, 1,203 potentially relevant reports were identified (Technical Appendix 1, 2) of which 447 (37%) were available online and assessed for eligibility (Figure 1).


Zoonotic Mycobacterium bovis-induced tuberculosis in humans.

Müller B, Dürr S, Alonso S, Hattendorf J, Laisse CJ, Parsons SD, van Helden PD, Zinsstag J - Emerging Infect. Dis. (2013)

Selection procedure for reports included in this analysis. A list of all identified 1,203 potentially relevant reports and the core dataset is available as supplemental material (online Technical Appendix 2, wwwnc.cdc.gov/EID/article/19/6/12-0543-Techapp2.xlsx). TB, tuberculosis; M. bovis, Mycobacterium bovis.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4816377&req=5

Figure 1: Selection procedure for reports included in this analysis. A list of all identified 1,203 potentially relevant reports and the core dataset is available as supplemental material (online Technical Appendix 2, wwwnc.cdc.gov/EID/article/19/6/12-0543-Techapp2.xlsx). TB, tuberculosis; M. bovis, Mycobacterium bovis.
Mentions: A systematic multilingual literature search was performed according to international guidelines with certain modifications (http://www.cochrane-handbook.org/). Potentially relevant reports on putative zoonotic TB caused by M. bovis or M. caprae were identified by a search of 32 bibliographic databases by using a highly sensitive search syntax. All publications/reports documented in the various databases and published until March 2010 were considered (Table 1, Technical Appendix 1, and Technical Appendix 2). Reference Manager v11.0.1 bibliographic software was used to store and remove duplicated reports, leaving 12,176 records (Figure 1). Titles and abstracts of these reports were screened to remove studies unlikely to contain pertinent information. Altogether, 1,203 potentially relevant reports were identified (Technical Appendix 1, 2) of which 447 (37%) were available online and assessed for eligibility (Figure 1).

Bottom Line: In regions outside Africa included in this study, overall median proportions of zoonotic TB of ≤1.4% in connection with overall TB incidence rates ≤71/100,000 population/year suggested low incidence rates.For countries of Africa included in the study, we multiplied the observed median proportion of zoonotic TB cases of 2.8% with the continental average overall TB incidence rate of 264/100,000 population/year, which resulted in a crude estimate of 7 zoonotic TB cases/100,000 population/year.These generally low incidence rates notwithstanding, available data indicated substantial consequences of this disease for some population groups and settings.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa. borna.mueller@gmail.com

ABSTRACT
We aimed to estimate the global occurrence of zoonotic tuberculosis (TB) caused by Mycobacterium bovis or M. caprae infections in humans by performing a multilingual, systematic review and analysis of relevant scientific literature of the last 2 decades. Although information from many parts of the world was not available, data from 61 countries suggested a low global disease incidence. In regions outside Africa included in this study, overall median proportions of zoonotic TB of ≤1.4% in connection with overall TB incidence rates ≤71/100,000 population/year suggested low incidence rates. For countries of Africa included in the study, we multiplied the observed median proportion of zoonotic TB cases of 2.8% with the continental average overall TB incidence rate of 264/100,000 population/year, which resulted in a crude estimate of 7 zoonotic TB cases/100,000 population/year. These generally low incidence rates notwithstanding, available data indicated substantial consequences of this disease for some population groups and settings.

Show MeSH
Related in: MedlinePlus