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Prevalence and Geographical Variation of Prothrombin G20210A Mutation in Patients with Cerebral Vein Thrombosis: A Systematic Review and Meta-Analysis.

Gonzalez JV, Barboza AG, Vazquez FJ, Gándara E - PLoS ONE (2016)

Bottom Line: The random-effects model OR was used as the primary outcome measure.Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the healthy controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%].Prothrombin G20210A is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario, Universidad Nacional de Cuyo, Mendoza, Argentina.

ABSTRACT

Objectives: To compare the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis against healthy controls, and evaluate geographical variations.

Design: Systematic review and meta-analysis of case control studies.

Methods: We conducted a systematic review of electronic databases including MEDLINE and EMBASE. The main outcome was the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis; we also analyzed individual country variations in the prevalence. The random-effects model OR was used as the primary outcome measure.

Results: In total 19 studies evaluated 868 cases of cerebral venous thrombosis and 3981 controls. Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the healthy controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%]. The prevalence of prothrombin G20210A was significantly elevated in Italian studies (OR 9.69), in Brazilian studies (OR 7.02), and in German studies (OR 3.77), but not in Iranian studies (OR 0.98).

Conclusion: Prothrombin G20210A is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

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Related in: MedlinePlus

L’Abbé bias plot.
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pone.0151607.g004: L’Abbé bias plot.

Mentions: In total the 19 studies evaluated 868 cases of cerebral venous thrombosis and 3999 controls (see Table 3 for a more comprehensive review of the number of patients included in each study individual OR and bias assessment). Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%] (Fig 2) with low evidence of bias (Figs 3 and 4). As shown in Table 3 the addition of the two relevant studies not reporting the diagnostic methods used did not modify the random effects pooled OR[13,26].


Prevalence and Geographical Variation of Prothrombin G20210A Mutation in Patients with Cerebral Vein Thrombosis: A Systematic Review and Meta-Analysis.

Gonzalez JV, Barboza AG, Vazquez FJ, Gándara E - PLoS ONE (2016)

L’Abbé bias plot.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4816324&req=5

pone.0151607.g004: L’Abbé bias plot.
Mentions: In total the 19 studies evaluated 868 cases of cerebral venous thrombosis and 3999 controls (see Table 3 for a more comprehensive review of the number of patients included in each study individual OR and bias assessment). Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%] (Fig 2) with low evidence of bias (Figs 3 and 4). As shown in Table 3 the addition of the two relevant studies not reporting the diagnostic methods used did not modify the random effects pooled OR[13,26].

Bottom Line: The random-effects model OR was used as the primary outcome measure.Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the healthy controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%].Prothrombin G20210A is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario, Universidad Nacional de Cuyo, Mendoza, Argentina.

ABSTRACT

Objectives: To compare the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis against healthy controls, and evaluate geographical variations.

Design: Systematic review and meta-analysis of case control studies.

Methods: We conducted a systematic review of electronic databases including MEDLINE and EMBASE. The main outcome was the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis; we also analyzed individual country variations in the prevalence. The random-effects model OR was used as the primary outcome measure.

Results: In total 19 studies evaluated 868 cases of cerebral venous thrombosis and 3981 controls. Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the healthy controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%]. The prevalence of prothrombin G20210A was significantly elevated in Italian studies (OR 9.69), in Brazilian studies (OR 7.02), and in German studies (OR 3.77), but not in Iranian studies (OR 0.98).

Conclusion: Prothrombin G20210A is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

Show MeSH
Related in: MedlinePlus