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Prevalence and Geographical Variation of Prothrombin G20210A Mutation in Patients with Cerebral Vein Thrombosis: A Systematic Review and Meta-Analysis.

Gonzalez JV, Barboza AG, Vazquez FJ, Gándara E - PLoS ONE (2016)

Bottom Line: The random-effects model OR was used as the primary outcome measure.Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the healthy controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%].Prothrombin G20210A is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario, Universidad Nacional de Cuyo, Mendoza, Argentina.

ABSTRACT

Objectives: To compare the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis against healthy controls, and evaluate geographical variations.

Design: Systematic review and meta-analysis of case control studies.

Methods: We conducted a systematic review of electronic databases including MEDLINE and EMBASE. The main outcome was the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis; we also analyzed individual country variations in the prevalence. The random-effects model OR was used as the primary outcome measure.

Results: In total 19 studies evaluated 868 cases of cerebral venous thrombosis and 3981 controls. Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the healthy controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%]. The prevalence of prothrombin G20210A was significantly elevated in Italian studies (OR 9.69), in Brazilian studies (OR 7.02), and in German studies (OR 3.77), but not in Iranian studies (OR 0.98).

Conclusion: Prothrombin G20210A is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

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Related in: MedlinePlus

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Mentions: As shown in fig 1 our initial electronic search identified 238 relevant abstracts (after removal of duplicates). One hundred and ninety five were considered non-relevant to the search and excluded. Of the 43 that were selected for full text review 21[10–30]were included in this review, 19[10–12,14,16–25,27–31]of which were used for the primary analysis (in Table 1 we present the studies characteristics and in Table 2 their quality assessment); 22 were excluded for the reasons described in Fig 1. Two studies were excluded from the primary analysis as they did not report the method used for the diagnosis of cerebral venous thrombosis[13,26]. Five of the studies were conducted in Italy[17,21,27,29,31], three in Brazil[18,25,28], three in Germany[10,20,24], two in Iran[16,23], one in France[19], one in India[32],one in Netherlands[30]one in Switzerland[11], one in Tunisia[14] and one in the United Kingdom[12].


Prevalence and Geographical Variation of Prothrombin G20210A Mutation in Patients with Cerebral Vein Thrombosis: A Systematic Review and Meta-Analysis.

Gonzalez JV, Barboza AG, Vazquez FJ, Gándara E - PLoS ONE (2016)

Flow diagram.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4816324&req=5

pone.0151607.g001: Flow diagram.
Mentions: As shown in fig 1 our initial electronic search identified 238 relevant abstracts (after removal of duplicates). One hundred and ninety five were considered non-relevant to the search and excluded. Of the 43 that were selected for full text review 21[10–30]were included in this review, 19[10–12,14,16–25,27–31]of which were used for the primary analysis (in Table 1 we present the studies characteristics and in Table 2 their quality assessment); 22 were excluded for the reasons described in Fig 1. Two studies were excluded from the primary analysis as they did not report the method used for the diagnosis of cerebral venous thrombosis[13,26]. Five of the studies were conducted in Italy[17,21,27,29,31], three in Brazil[18,25,28], three in Germany[10,20,24], two in Iran[16,23], one in France[19], one in India[32],one in Netherlands[30]one in Switzerland[11], one in Tunisia[14] and one in the United Kingdom[12].

Bottom Line: The random-effects model OR was used as the primary outcome measure.Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the healthy controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%].Prothrombin G20210A is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario, Universidad Nacional de Cuyo, Mendoza, Argentina.

ABSTRACT

Objectives: To compare the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis against healthy controls, and evaluate geographical variations.

Design: Systematic review and meta-analysis of case control studies.

Methods: We conducted a systematic review of electronic databases including MEDLINE and EMBASE. The main outcome was the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis; we also analyzed individual country variations in the prevalence. The random-effects model OR was used as the primary outcome measure.

Results: In total 19 studies evaluated 868 cases of cerebral venous thrombosis and 3981 controls. Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the healthy controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%]. The prevalence of prothrombin G20210A was significantly elevated in Italian studies (OR 9.69), in Brazilian studies (OR 7.02), and in German studies (OR 3.77), but not in Iranian studies (OR 0.98).

Conclusion: Prothrombin G20210A is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

Show MeSH
Related in: MedlinePlus