Limits...
Laparoscopic gastrectomy versus open gastrectomy for elderly patients with gastric cancer: a systematic review and meta-analysis.

Wang JF, Zhang SZ, Zhang NY, Wu ZY, Feng JY, Ying LP, Zhang JJ - World J Surg Oncol (2016)

Bottom Line: No significant differences were observed between LG and OG for the number of harvested lymph nodes.However, LG had longer operative times (WMD 15.73; 95% CI 6.23 to 25.23; P < 0.01).Compared with OG, LG has less blood loss, faster postoperative recovery, and reduced postoperative morbidity.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Yinzhou People's Hospital, Yinzhou Hospital Affiliated to Medical School of Ningbo University, 251 Baizhang Road, Ningbo, 315040, Zhejiang, People's Republic of China.

ABSTRACT

Background: The objective of this study was to evaluate the feasibility, safety, and potential benefits of laparoscopic gastrectomy (LG) comparing with open gastrectomy (OG) in elderly population.

Methods: Studies comparing LG with OG for elderly population with gastric cancer, published between January 1994 and July 2015, were identified in the PubMed, Embase, and ISI Web of Science databases. Operative outcomes (intraoperative blood loss, operative time, and the number of lymph nodes harvested) and postoperative outcomes (time to first ambulation, time to first flatus, time to first oral intake, postoperative hospital stay, postoperative morbidity) were included and analyzed. The Newcastle-Ottawa Scale was used to assess the quality of the pooled study. A funnel plot was used to evaluate the publication bias.

Results: Seven studies totaling 845 patients were included in the meta-analysis. LG in comparison to OG showed less intraoperative blood loss (weighted mean difference (WMD) -127.47; 95% confidence interval (CI) -202.79 to -52.16; P < 0.01), earlier time to first ambulation (WMD -2.07; 95% CI -2.84 to -1.30; P < 0.01), first flatus (WMD -1.04; 95% CI -1.45 to -0.63; P < 0.01), and oral intake (WMD -0.94; 95% CI -1.11 to -0.77; P < 0.01), postoperative hospital stay (WMD -5.26; 95% CI -7.58 to -2.93; P < 0.01), lower overall postoperative complication rate (odd ratio (OR) 0.39; 95% CI 0.28 to 0.55; P < 0.01), less surgical complications (OR 0.47; 95% CI 0.32 to 0.69; P < 0.01), medical complication (OR 0.35; 95% CI 0.22 to 0.56; P < 0.01), incisional complication (OR 0.40; 95% CI 0.19 to 0.85; P = 0.02), and pulmonary infection (OR 0.49; 95% CI 0.26 to 0.93; P = 0.03). No significant differences were observed between LG and OG for the number of harvested lymph nodes. However, LG had longer operative times (WMD 15.73; 95% CI 6.23 to 25.23; P < 0.01).

Conclusions: LG is a feasible and safe approach for elderly patients with gastric cancer. Compared with OG, LG has less blood loss, faster postoperative recovery, and reduced postoperative morbidity.

No MeSH data available.


Related in: MedlinePlus

Funnel plot of meta-analysis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4815084&req=5

Fig5: Funnel plot of meta-analysis

Mentions: Sensitivity analyses were conducted by exclusion of the highest weighted study in each pooled analysis. These exclusions did not alter the results obtained in cumulative analyses. Funnel plot based on the overall postoperative complication was performed to assess publication bias. No significant publication bias was detected by visual inspection of the funnel plot in which the pooled studies were almost symmetrical and none of them was outside the 95 % CI (Fig. 5).Fig. 5


Laparoscopic gastrectomy versus open gastrectomy for elderly patients with gastric cancer: a systematic review and meta-analysis.

Wang JF, Zhang SZ, Zhang NY, Wu ZY, Feng JY, Ying LP, Zhang JJ - World J Surg Oncol (2016)

Funnel plot of meta-analysis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4815084&req=5

Fig5: Funnel plot of meta-analysis
Mentions: Sensitivity analyses were conducted by exclusion of the highest weighted study in each pooled analysis. These exclusions did not alter the results obtained in cumulative analyses. Funnel plot based on the overall postoperative complication was performed to assess publication bias. No significant publication bias was detected by visual inspection of the funnel plot in which the pooled studies were almost symmetrical and none of them was outside the 95 % CI (Fig. 5).Fig. 5

Bottom Line: No significant differences were observed between LG and OG for the number of harvested lymph nodes.However, LG had longer operative times (WMD 15.73; 95% CI 6.23 to 25.23; P < 0.01).Compared with OG, LG has less blood loss, faster postoperative recovery, and reduced postoperative morbidity.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Yinzhou People's Hospital, Yinzhou Hospital Affiliated to Medical School of Ningbo University, 251 Baizhang Road, Ningbo, 315040, Zhejiang, People's Republic of China.

ABSTRACT

Background: The objective of this study was to evaluate the feasibility, safety, and potential benefits of laparoscopic gastrectomy (LG) comparing with open gastrectomy (OG) in elderly population.

Methods: Studies comparing LG with OG for elderly population with gastric cancer, published between January 1994 and July 2015, were identified in the PubMed, Embase, and ISI Web of Science databases. Operative outcomes (intraoperative blood loss, operative time, and the number of lymph nodes harvested) and postoperative outcomes (time to first ambulation, time to first flatus, time to first oral intake, postoperative hospital stay, postoperative morbidity) were included and analyzed. The Newcastle-Ottawa Scale was used to assess the quality of the pooled study. A funnel plot was used to evaluate the publication bias.

Results: Seven studies totaling 845 patients were included in the meta-analysis. LG in comparison to OG showed less intraoperative blood loss (weighted mean difference (WMD) -127.47; 95% confidence interval (CI) -202.79 to -52.16; P < 0.01), earlier time to first ambulation (WMD -2.07; 95% CI -2.84 to -1.30; P < 0.01), first flatus (WMD -1.04; 95% CI -1.45 to -0.63; P < 0.01), and oral intake (WMD -0.94; 95% CI -1.11 to -0.77; P < 0.01), postoperative hospital stay (WMD -5.26; 95% CI -7.58 to -2.93; P < 0.01), lower overall postoperative complication rate (odd ratio (OR) 0.39; 95% CI 0.28 to 0.55; P < 0.01), less surgical complications (OR 0.47; 95% CI 0.32 to 0.69; P < 0.01), medical complication (OR 0.35; 95% CI 0.22 to 0.56; P < 0.01), incisional complication (OR 0.40; 95% CI 0.19 to 0.85; P = 0.02), and pulmonary infection (OR 0.49; 95% CI 0.26 to 0.93; P = 0.03). No significant differences were observed between LG and OG for the number of harvested lymph nodes. However, LG had longer operative times (WMD 15.73; 95% CI 6.23 to 25.23; P < 0.01).

Conclusions: LG is a feasible and safe approach for elderly patients with gastric cancer. Compared with OG, LG has less blood loss, faster postoperative recovery, and reduced postoperative morbidity.

No MeSH data available.


Related in: MedlinePlus