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Osteoprotegerin, s-RANKL, and selected interleukins in the pathology of bone metabolism in patients with Crohn's disease.

Krela-Kaźmierczak I, Wysocka E, Szymczak A, Eder P, Michalak M, Łykowska-Szuber L, Stawczyk-Eder K, Klimczak K, Linke K, Horst-Sikorska W - Prz Gastroenterol (2015)

Bottom Line: The IL-13 and IL-1β concentrations were significantly higher and OPG was significantly lower in CD patients when compared to controls.IL-13, IL-1β, and IL-4 seem to be connected with the pathology of decreased BMD in CD.It can be hypothesised that IL-13 may lower BMD by modulating OPG.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.

ABSTRACT

Introduction: Crohn's disease (CD) promotes the development of osteopaenia/osteoporosis, the cytokine background of which is not fully known.

Aim: Evaluation of bone mineral density (BMD), the prevalence of osteopaenia and osteoporosis, and the determination of the levels of selected interleukins (IL), osteoprotegerin (OPG), and s-RANKL proteins in patients with CD in relation to a control group and assessment of the relationship between the tested cytokines, OPG, s-RANKL, and BMD.

Material and methods: Thirty-seven CD patients and 37 healthy volunteers (control group) were enrolled into the study. Densitometry of the lumbar spine (L2-L4) and of the femoral neck using the DXA technique was carried out. Serum levels of: IL-13, IL-4, IL-17, IL-1β, OPG, and s-RANKL were determined using the ELISA method. Progression-of-disease questionnaires were collected.

Results: The prevalence of osteoporosis and osteopaenia in the CD group was: 18.92% and 32.43% in L2-L4; 13.51% and 35.13% in the neck, respectively. The IL-13 and IL-1β concentrations were significantly higher and OPG was significantly lower in CD patients when compared to controls. In the case of all subjects: IL-13 correlated negatively with the BMD of the neck, IL-17 correlated negatively with the Z-score of L2-L4, and OPG correlated negatively with the IL-13. In the case of CD patients, IL-4 correlated negatively with the BMD of L2-L4.

Conclusions: The incidence of osteopaenia and osteoporosis in Polish CD patients is high. IL-13, IL-1β, and IL-4 seem to be connected with the pathology of decreased BMD in CD. It can be hypothesised that IL-13 may lower BMD by modulating OPG.

No MeSH data available.


Related in: MedlinePlus

A – Correlation between IL-13 levels and bone mineral density of the neck (r = –0.2; p = 0.3) in the whole study group. B – Correlation between IL-13 and osteoprotegerin levels (r = –0.5; p < 0.0001) in the whole study group
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Figure 0001: A – Correlation between IL-13 levels and bone mineral density of the neck (r = –0.2; p = 0.3) in the whole study group. B – Correlation between IL-13 and osteoprotegerin levels (r = –0.5; p < 0.0001) in the whole study group

Mentions: In the case of all subjects: IL-13 correlated negatively with the BMD of the neck (r = –0.20, p = 0.0318), IL-17 correlated negatively with the Z-score of L2–L4 (r = –0.32, p = 0.0005), and OPG correlated negatively with the IL-13 (r = –0.51, p < 0.0001) (Figure 1). In the case of CD patients, IL-4 correlated negatively with the BMD of L2–L4 (r = –0.32, p = 0.0491).


Osteoprotegerin, s-RANKL, and selected interleukins in the pathology of bone metabolism in patients with Crohn's disease.

Krela-Kaźmierczak I, Wysocka E, Szymczak A, Eder P, Michalak M, Łykowska-Szuber L, Stawczyk-Eder K, Klimczak K, Linke K, Horst-Sikorska W - Prz Gastroenterol (2015)

A – Correlation between IL-13 levels and bone mineral density of the neck (r = –0.2; p = 0.3) in the whole study group. B – Correlation between IL-13 and osteoprotegerin levels (r = –0.5; p < 0.0001) in the whole study group
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4814538&req=5

Figure 0001: A – Correlation between IL-13 levels and bone mineral density of the neck (r = –0.2; p = 0.3) in the whole study group. B – Correlation between IL-13 and osteoprotegerin levels (r = –0.5; p < 0.0001) in the whole study group
Mentions: In the case of all subjects: IL-13 correlated negatively with the BMD of the neck (r = –0.20, p = 0.0318), IL-17 correlated negatively with the Z-score of L2–L4 (r = –0.32, p = 0.0005), and OPG correlated negatively with the IL-13 (r = –0.51, p < 0.0001) (Figure 1). In the case of CD patients, IL-4 correlated negatively with the BMD of L2–L4 (r = –0.32, p = 0.0491).

Bottom Line: The IL-13 and IL-1β concentrations were significantly higher and OPG was significantly lower in CD patients when compared to controls.IL-13, IL-1β, and IL-4 seem to be connected with the pathology of decreased BMD in CD.It can be hypothesised that IL-13 may lower BMD by modulating OPG.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.

ABSTRACT

Introduction: Crohn's disease (CD) promotes the development of osteopaenia/osteoporosis, the cytokine background of which is not fully known.

Aim: Evaluation of bone mineral density (BMD), the prevalence of osteopaenia and osteoporosis, and the determination of the levels of selected interleukins (IL), osteoprotegerin (OPG), and s-RANKL proteins in patients with CD in relation to a control group and assessment of the relationship between the tested cytokines, OPG, s-RANKL, and BMD.

Material and methods: Thirty-seven CD patients and 37 healthy volunteers (control group) were enrolled into the study. Densitometry of the lumbar spine (L2-L4) and of the femoral neck using the DXA technique was carried out. Serum levels of: IL-13, IL-4, IL-17, IL-1β, OPG, and s-RANKL were determined using the ELISA method. Progression-of-disease questionnaires were collected.

Results: The prevalence of osteoporosis and osteopaenia in the CD group was: 18.92% and 32.43% in L2-L4; 13.51% and 35.13% in the neck, respectively. The IL-13 and IL-1β concentrations were significantly higher and OPG was significantly lower in CD patients when compared to controls. In the case of all subjects: IL-13 correlated negatively with the BMD of the neck, IL-17 correlated negatively with the Z-score of L2-L4, and OPG correlated negatively with the IL-13. In the case of CD patients, IL-4 correlated negatively with the BMD of L2-L4.

Conclusions: The incidence of osteopaenia and osteoporosis in Polish CD patients is high. IL-13, IL-1β, and IL-4 seem to be connected with the pathology of decreased BMD in CD. It can be hypothesised that IL-13 may lower BMD by modulating OPG.

No MeSH data available.


Related in: MedlinePlus