Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer.
Bottom Line: However, the effect on the host immune system, especially on invariant NKT (iNKT) cells with potent anti-tumor activity, remains unclear.However, iNKT cell activation upon α-galactosylceramide (αGalCer) stimulation was not affected by the presence or absence of CD15+ G-MDSC.Cancer immunotherapy designed to enhance the antitumor activity of iNKT cells by stimulation with αGalCer may remain effective in the presence of G-MDSC.
Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.Show MeSH
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Mentions: The percentage of CD14+ HLA‐DR−/low M‐MDSC was significantly elevated in patients with HNSCC (Fig. 2a). There was no significant correlation between the percentages of M‐MDSC and lymphocytes in the white blood cell fraction or CD3+, CD19+, CD56+ and Vα24+ Vβ11+ cells in the PBC of HNSCC patients (Fig. 2b–f).
Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.