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Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer.

Horinaka A, Sakurai D, Ihara F, Makita Y, Kunii N, Motohashi S, Nakayama T, Okamoto Y - Cancer Sci. (2016)

Bottom Line: However, the effect on the host immune system, especially on invariant NKT (iNKT) cells with potent anti-tumor activity, remains unclear.However, iNKT cell activation upon α-galactosylceramide (αGalCer) stimulation was not affected by the presence or absence of CD15+ G-MDSC.Cancer immunotherapy designed to enhance the antitumor activity of iNKT cells by stimulation with αGalCer may remain effective in the presence of G-MDSC.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

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Related in: MedlinePlus

Percentage of monocytic‐myeloid‐derived suppressor cells (M‐MDSC) in peripheral blood cells and the correlation with the percentage of peripheral lymphocytes. (a) The percentage of CD14+ HLA‐DR−/low M‐MDSC from healthy donors and patients with pleomorphic adenoma, thyroid papillary carcinoma and head and neck squamous cell carcinoma (HNSCC). (b) The correlation between the percentage of M‐MDSC and the percentage of circulating lymphocytes in HNSCC patients. (c–f) The correlation between the percentage of M‐MDSC and lymphocyte subsets in HNSCC patients. **P < 0.01.
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cas12866-fig-0002: Percentage of monocytic‐myeloid‐derived suppressor cells (M‐MDSC) in peripheral blood cells and the correlation with the percentage of peripheral lymphocytes. (a) The percentage of CD14+ HLA‐DR−/low M‐MDSC from healthy donors and patients with pleomorphic adenoma, thyroid papillary carcinoma and head and neck squamous cell carcinoma (HNSCC). (b) The correlation between the percentage of M‐MDSC and the percentage of circulating lymphocytes in HNSCC patients. (c–f) The correlation between the percentage of M‐MDSC and lymphocyte subsets in HNSCC patients. **P < 0.01.

Mentions: The percentage of CD14+ HLA‐DR−/low M‐MDSC was significantly elevated in patients with HNSCC (Fig. 2a). There was no significant correlation between the percentages of M‐MDSC and lymphocytes in the white blood cell fraction or CD3+, CD19+, CD56+ and Vα24+ Vβ11+ cells in the PBC of HNSCC patients (Fig. 2b–f).


Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer.

Horinaka A, Sakurai D, Ihara F, Makita Y, Kunii N, Motohashi S, Nakayama T, Okamoto Y - Cancer Sci. (2016)

Percentage of monocytic‐myeloid‐derived suppressor cells (M‐MDSC) in peripheral blood cells and the correlation with the percentage of peripheral lymphocytes. (a) The percentage of CD14+ HLA‐DR−/low M‐MDSC from healthy donors and patients with pleomorphic adenoma, thyroid papillary carcinoma and head and neck squamous cell carcinoma (HNSCC). (b) The correlation between the percentage of M‐MDSC and the percentage of circulating lymphocytes in HNSCC patients. (c–f) The correlation between the percentage of M‐MDSC and lymphocyte subsets in HNSCC patients. **P < 0.01.
© Copyright Policy - creativeCommonsBy-nc-nd
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4814259&req=5

cas12866-fig-0002: Percentage of monocytic‐myeloid‐derived suppressor cells (M‐MDSC) in peripheral blood cells and the correlation with the percentage of peripheral lymphocytes. (a) The percentage of CD14+ HLA‐DR−/low M‐MDSC from healthy donors and patients with pleomorphic adenoma, thyroid papillary carcinoma and head and neck squamous cell carcinoma (HNSCC). (b) The correlation between the percentage of M‐MDSC and the percentage of circulating lymphocytes in HNSCC patients. (c–f) The correlation between the percentage of M‐MDSC and lymphocyte subsets in HNSCC patients. **P < 0.01.
Mentions: The percentage of CD14+ HLA‐DR−/low M‐MDSC was significantly elevated in patients with HNSCC (Fig. 2a). There was no significant correlation between the percentages of M‐MDSC and lymphocytes in the white blood cell fraction or CD3+, CD19+, CD56+ and Vα24+ Vβ11+ cells in the PBC of HNSCC patients (Fig. 2b–f).

Bottom Line: However, the effect on the host immune system, especially on invariant NKT (iNKT) cells with potent anti-tumor activity, remains unclear.However, iNKT cell activation upon α-galactosylceramide (αGalCer) stimulation was not affected by the presence or absence of CD15+ G-MDSC.Cancer immunotherapy designed to enhance the antitumor activity of iNKT cells by stimulation with αGalCer may remain effective in the presence of G-MDSC.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Show MeSH
Related in: MedlinePlus