Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer.
Bottom Line: However, the effect on the host immune system, especially on invariant NKT (iNKT) cells with potent anti-tumor activity, remains unclear.However, iNKT cell activation upon α-galactosylceramide (αGalCer) stimulation was not affected by the presence or absence of CD15+ G-MDSC.Cancer immunotherapy designed to enhance the antitumor activity of iNKT cells by stimulation with αGalCer may remain effective in the presence of G-MDSC.
Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.Show MeSH
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Mentions: Compared with healthy donors, a significant increase in CD14+ HLA‐DR−/low M‐MDSC and HLA‐DR− Lin− CD15+ G‐MDSC was observed in HNSCC patients. No significant correlation was seen between the patient age and the ratio of M‐MDSC or G‐MDSC in HNSCC patients (data not shown). Representative staining profiles of M‐MDSC and G‐MDSC are shown (Fig. 1a–c). The CD15+ cells were also positive for both CD11b and CD33 (Fig. 1c). However, there was no correlation between the percentage of G‐MDSC and M‐MDSC (Fig. 1d).
Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.