Antibody-dependent cellular cytotoxicity toward neuroblastoma enhanced by activated invariant natural killer T cells.
Bottom Line: For further improvement in patient outcomes, ways to maximize the cytotoxic effects of anti-GD2 therapies with minimal toxicity are required.Although some of the expanded iNKT cells expressed natural killer (NK) cell markers, including FcγR, iNKT cells were not directly associated with ADCC.In conclusion, iNKT cell-based immunotherapy could be an appropriate candidate for anti-GD2 antibody therapy for neuroblastoma.
Affiliation: Department of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.Show MeSH
Related in: MedlinePlus
Mentions: As the activation of iNKT cells is CD1d restricted, the CD1d expression of several NB cell lines was first examined by flow cytometry. As previously described,23 CD1d was expressed on hematopoietic cells, such as Jurkat and THP‐1 cells (Fig. 1b), but it was not expressed on the surface of NB cell lines (Fig. 1a).
Affiliation: Department of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.