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Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma.

Saito Y, Nagae G, Motoi N, Miyauchi E, Ninomiya H, Uehara H, Mun M, Okumura S, Ohyanagi F, Nishio M, Satoh Y, Aburatani H, Ishikawa Y - Cancer Sci. (2016)

Bottom Line: Multivariate analyses revealed that postoperative chemotherapy and non-CIMP were significantly good prognostic factors.Ontology analyses suggested that the extrinsic apoptosis pathway was suppressed, including TNFRSF1A, TNFRSF10A and TRADD in CIMP tumors.Delineation of this phenotype may also be useful for the development of novel apoptosis-related chemotherapeutic agents for treatment of the aggressive tumor.

View Article: PubMed Central - PubMed

Affiliation: Division of Pathology, The Cancer Institute, Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

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Related in: MedlinePlus

Disease‐free survival analysis by Kaplan–Meier method for the two clusters obtained by two clustering methods. Survival of Cluster 1 with high CpG methylator phenotype (CIMP) was significantly poorer than that of Cluster 2 with non‐CIMP (P = 0.002). The 5‐year disease‐free rates in Cluster 1 (n = 9) and in Cluster 2 (n = 19) were 11.1 and 62.7%, respectively. The median disease‐free survival was 9.6 months for Cluster 1 and 86.9 months for Cluster 2.
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cas12876-fig-0005: Disease‐free survival analysis by Kaplan–Meier method for the two clusters obtained by two clustering methods. Survival of Cluster 1 with high CpG methylator phenotype (CIMP) was significantly poorer than that of Cluster 2 with non‐CIMP (P = 0.002). The 5‐year disease‐free rates in Cluster 1 (n = 9) and in Cluster 2 (n = 19) were 11.1 and 62.7%, respectively. The median disease‐free survival was 9.6 months for Cluster 1 and 86.9 months for Cluster 2.

Mentions: During the median follow‐up period of 37.4 months, 16 patients suffered cancer relapse: 8 (8/9, 89%) in Cluster 1 and 8 (8/19, 42%) in Cluster 2. The 5‐year disease‐free survival (DFS) rate for the entire group was 46.2%, and the 5‐year DFS of Cluster 1 (11.1%) was much lower than that of Cluster 2 (62.7%). These differences are highly significant (Fig. 5, P = 0.002).


Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma.

Saito Y, Nagae G, Motoi N, Miyauchi E, Ninomiya H, Uehara H, Mun M, Okumura S, Ohyanagi F, Nishio M, Satoh Y, Aburatani H, Ishikawa Y - Cancer Sci. (2016)

Disease‐free survival analysis by Kaplan–Meier method for the two clusters obtained by two clustering methods. Survival of Cluster 1 with high CpG methylator phenotype (CIMP) was significantly poorer than that of Cluster 2 with non‐CIMP (P = 0.002). The 5‐year disease‐free rates in Cluster 1 (n = 9) and in Cluster 2 (n = 19) were 11.1 and 62.7%, respectively. The median disease‐free survival was 9.6 months for Cluster 1 and 86.9 months for Cluster 2.
© Copyright Policy - creativeCommonsBy-nc
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4814245&req=5

cas12876-fig-0005: Disease‐free survival analysis by Kaplan–Meier method for the two clusters obtained by two clustering methods. Survival of Cluster 1 with high CpG methylator phenotype (CIMP) was significantly poorer than that of Cluster 2 with non‐CIMP (P = 0.002). The 5‐year disease‐free rates in Cluster 1 (n = 9) and in Cluster 2 (n = 19) were 11.1 and 62.7%, respectively. The median disease‐free survival was 9.6 months for Cluster 1 and 86.9 months for Cluster 2.
Mentions: During the median follow‐up period of 37.4 months, 16 patients suffered cancer relapse: 8 (8/9, 89%) in Cluster 1 and 8 (8/19, 42%) in Cluster 2. The 5‐year disease‐free survival (DFS) rate for the entire group was 46.2%, and the 5‐year DFS of Cluster 1 (11.1%) was much lower than that of Cluster 2 (62.7%). These differences are highly significant (Fig. 5, P = 0.002).

Bottom Line: Multivariate analyses revealed that postoperative chemotherapy and non-CIMP were significantly good prognostic factors.Ontology analyses suggested that the extrinsic apoptosis pathway was suppressed, including TNFRSF1A, TNFRSF10A and TRADD in CIMP tumors.Delineation of this phenotype may also be useful for the development of novel apoptosis-related chemotherapeutic agents for treatment of the aggressive tumor.

View Article: PubMed Central - PubMed

Affiliation: Division of Pathology, The Cancer Institute, Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

Show MeSH
Related in: MedlinePlus