Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma.
Bottom Line: Multivariate analyses revealed that postoperative chemotherapy and non-CIMP were significantly good prognostic factors.Ontology analyses suggested that the extrinsic apoptosis pathway was suppressed, including TNFRSF1A, TNFRSF10A and TRADD in CIMP tumors.Delineation of this phenotype may also be useful for the development of novel apoptosis-related chemotherapeutic agents for treatment of the aggressive tumor.
Affiliation: Division of Pathology, The Cancer Institute, Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.Show MeSH
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Mentions: During the median follow‐up period of 37.4 months, 16 patients suffered cancer relapse: 8 (8/9, 89%) in Cluster 1 and 8 (8/19, 42%) in Cluster 2. The 5‐year disease‐free survival (DFS) rate for the entire group was 46.2%, and the 5‐year DFS of Cluster 1 (11.1%) was much lower than that of Cluster 2 (62.7%). These differences are highly significant (Fig. 5, P = 0.002).
Affiliation: Division of Pathology, The Cancer Institute, Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.